4-prop-2-enyl-1H-pyrrole-2-carbaldehyde | 117720-05-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-prop-2-enyl-1H-pyrrole-2-carbaldehyde
• CAS: 117720-05-5
• 化学式: C₈H₉NO
• mdl: MFCD02179589
• 分子量: 135.166
• InChiKey: IFNIXRUGOHXMLR-UHFFFAOYSA-N

物化性质

• 沸点：
  250.4±28.0 °C(Predicted)
• 密度：
  1.091±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-prop-2-enyl-1H-pyrrole-2-carbaldehyde 在 盐酸 、 4 A molecular sieve 、 sodium hydride 、 sodium cyanoborohydride 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 paraffin 为溶剂， 反应 19.0h， 生成
  参考文献：
  名称：

  Ethyl a-Amino-b,b-Diethoxypropionate, a Useful Synthon for the Preparation of 3,4-Fused Pyridine-6-carboxylates from Aromatic Aldehydes

  摘要：

  DOI：

  10.3987/com-96-s30
• 作为产物：
  描述：

  5,11-dibromo-2-N,2-N,8-N,8-N-tetramethyl-1,7-diazatricyclo[7.3.0.03,7]dodeca-3,5,9,11-tetraene-2,8-diamine 在 正丁基锂 、 碳酸氢钠 作用下， 反应 0.5h， 生成 4-prop-2-enyl-1H-pyrrole-2-carbaldehyde
  参考文献：
  名称：

  3-溴-6-二甲基氨基-1-氮杂富烯的二聚体的锂化。有效合成4-单-和4,5-二取代的吡咯-2-甲醛

  摘要：

  3-溴-6-二甲基am1no-1-氮杂富烯的二聚体显示出与4-硫代或4.5-二硫代吡咯-2-碳醛的形式等效，因此，它是4-mono的祖先。 -和4,5-二取代的吡咯-2-甲醛。

  DOI：

  10.1016/0040-4039(88)85125-6

文献信息

• Improved synthesis of pyrrolo[1,2-c]pyrimidine and derivatives
  作者：JoséM. Minguez、Juan J. Vaquero、JoséL. García-Navio、Julio Alvarez-Builla

  DOI：10.1016/0040-4039(96)00812-x

  日期：1996.6

  An improved synthesis of pyrrolo[1,2-c]pyrimidine derivatives by cyclocondensation of pyrrole-2-carboxaldehydes with tosylmethyl isocyanide followed by desulfonylation of the resulting 2-tosylpyrrolo[1,2-c]-pyrimidines with sodium amalgam is described

  描述了一种改进的合成吡咯并[1,2- c ]嘧啶衍生物的方法，该方法是将吡咯-2-羧酸与甲苯磺酰基甲基异氰酸酯进行环缩合，然后将所得的2-甲苯磺酰基吡咯并[1,2 - c ]-嘧啶与汞齐钠进行磺酰化
• Novel Pyrrole Derivatives with Angiotensin II Antagonist Activity
  申请人：Makovec Francesco

  公开号：US20070244170A1

  公开（公告）日：2007-10-18

  Compounds which may be represented by the general formula (I) shown below and in which: R 1 is a group independently selected from among: CHO, —COOH, —CH 2 OH R 2 is hydrogen or a linear or branched C 1 -C 6 alkyl group R 3 is hydrogen or a halogen group selected from among Cl and Br R 4 is a linear or branched C 3 -C 5 alkyl group and the pharmaceutically acceptable salts thereof such as the sodium or potassium salt. The compounds exhibit potent and selective All antagonist activity and are useful for the treatment of any disorders in which elevated synthesis of All or overexpression of the AT 1 receptor may play a primary pathological role, as in the case of arterial hypertension, congestive cardiac insufficiency, platelet aggregation and disorders associated therewith such as for example myocardial and cerebral infarction, renal ischaemia, venous and arterial thrombosis, peripheral vasculopathy, pulmonary hypertension, diabetes mellitus, diabetic neuropathy, glaucoma and diabetic retinopathy.

  化合物可以用下面的通式（I）表示，其中：R1是从以下组中独立选择的一组：CHO，—COOH，—CH2OH；R2是氢或线性或支链的C1-C6烷基；R3是氢或从Cl和Br中选择的卤素基团；R4是线性或支链的C3-C5烷基团，以及其药学上可接受的盐，例如钠盐或钾盐。这些化合物表现出强效和选择性的All拮抗活性，并且可用于治疗任何升高的All合成或AT1受体过度表达可能起主要病理作用的疾病，例如动脉高血压、充血性心力衰竭、血小板聚集和与之相关的疾病，例如心肌梗死和脑梗死、肾缺血、静脉和动脉血栓形成、周围血管病、肺动脉高压、糖尿病、糖尿病神经病变、青光眼和糖尿病性视网膜病变。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• Pyrrolodiazines. 5. Synthesis, Structure, and Chemistry of Pyrrolo[1,2-<i>c</i>]pyrimidine. Dipolar Cycloaddition of Pyrrolo[1,2-<i>c</i>]pyrimidinium Ylides
  作者：José M. Minguez、Juan J. Vaquero、Julio Alvarez-Builla、Obis Castaño、José L. Andrés

  DOI：10.1021/jo9907080

  日期：1999.10.1

  An improved synthesis of pyrrolo[1,2-c]pyrimidines, including the parent system, was accomplished via sequential condensation of substituted pyrrole-2-carboxaldehydes with tosylmethyl isocyanide (TOSMIC), followed by desulfonylation of the formed tosylpyrrolo[1,2-c]pyrimidines. Based on the ab initio calculations performed on the pyrrolo[1,2-c]pyrimidine 1a, some of the basic chemistry was investigated including electrophilic substitution, addition of organolithium reagents, metalation with lithium diisopropylamide (LDA) and subsequent reaction with electrophiles, and formation of salts by quaternization of the nonbridgehead nitrogen. Azomethine ylides generated from pyrrolo[1,2-c]pyrimidinium salts undergo 1,3-dipolar cycloaddition with suitable dipolarophiles to give new dipyrrolo[1,2-a;1',2'-c]pyrimidine derivatives, with high regio- and stereoselectivity.
• MUCHOWSKI, JOSEPH M.;HESS, PETR, TETRAHEDRON LETT., 29,(1988) N 26, 3215-3218
  作者：MUCHOWSKI, JOSEPH M.、HESS, PETR

  DOI：——

  日期：——