[5-(1,1,2,2,2-Pentafluoroethyl)-2-phenyl-4-(trifluoromethyl)pyrazol-3-yl]hydrazine | 132631-91-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [5-(1,1,2,2,2-Pentafluoroethyl)-2-phenyl-4-(trifluoromethyl)pyrazol-3-yl]hydrazine
• CAS: 132631-91-5
• 化学式: C₁₂H₈F₈N₄
• 分子量: 360.21
• InChiKey: VACFPYKQTWICPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55.9
• 氢给体数：
  2
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  triethylammonium perfluoro-2-methyl-1-ethyl-1-propepenolate 在 三乙胺 、 肼 作用下， 以 乙二醇二甲醚 为溶剂， 反应 2.0h， 生成 [5-(1,1,2,2,2-Pentafluoroethyl)-2-phenyl-4-(trifluoromethyl)pyrazol-3-yl]hydrazine
  参考文献：
  名称：

  5-Fluoro-substituted pyrazoles

  摘要：

  A preparative method was developed for the synthesis of 5-fluoro-substituted pyrazoles by the reaction of fluoroolefins with substituted hydrazines in the presence of triethylamine. The fluorine atom at the C5 position of the pyrazoles obtained is readily substituted by O-, N-, and S-nucleophiles with the formation of 5-alkoxy-, amino-, mercapto-substituted fluoroalkylpyrazoles.

  DOI：

  10.1007/bf00958848

文献信息

• 5-Fluoro-substituted pyrazoles
  作者：M. D. Bargamova、S. M. Motsishkite、I. L. Knunyants

  DOI：10.1007/bf00958848

  日期：1990.11

  A preparative method was developed for the synthesis of 5-fluoro-substituted pyrazoles by the reaction of fluoroolefins with substituted hydrazines in the presence of triethylamine. The fluorine atom at the C5 position of the pyrazoles obtained is readily substituted by O-, N-, and S-nucleophiles with the formation of 5-alkoxy-, amino-, mercapto-substituted fluoroalkylpyrazoles.