2-氨基-3-甲氧基吡啶 | 10201-71-5

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-氨基-3-甲氧基吡啶
• 英文名称: 3-methoxypyridin-2-amine
• 英文别名: 2-amino-3-methoxypyridine；3-methoxy-pyridin-2-ylamine
• CAS: 10201-71-5
• 化学式: C₆H₈N₂O
• mdl: MFCD07374874
• 分子量: 124.142
• InChiKey: HNAYRVKSWGSQTP-UHFFFAOYSA-N

物化性质

• 沸点：
  235.0±20.0 °C(Predicted)
• 密度：
  1.139±0.06 g/cm3(Predicted)
• 熔点：
  71-76 °C ()
• pKa：
  8.43±0.10 (Predicted,Most Basic Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R22
• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  存储条件：2-8°C，避光，惰性气体环境中保存。

SDS

---

SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name : 2-Amino-3-Methoxypyridine
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

---

SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xn Harmful R22
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Warning
Hazard statement(s)
H302 Harmful if swallowed.
Precautionary statement(s) none
Supplemental Hazard none
Statements
Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

---

SECTION 3: Composition/information on ingredients
Substances
Molecular weight : 124,14 g/mol
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
2-Amino-3-Methoxypyridine
Acute Tox. 4; H302 <= 100 %
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration
2-Amino-3-Methoxypyridine
Xn, R22 <= 100 %
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

---

SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
No data available

---

SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Nature of decomposition products not known.
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
No data available

---

SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

---

SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Storage class (TRGS 510): Non Combustible Solids
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

---

SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

---

SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing No data available
point
f) Initial boiling point and No data available
boiling range
g) Flash point No data available
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower No data available
flammability or
explosive limits
k) Vapour pressure No data available
l) Vapour density No data available
m) Relative density No data available
n) Water solubility No data available
o) Partition coefficient: n- No data available
octanol/water
p) Auto-ignition No data available
temperature
q) Decomposition No data available
temperature
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
Other safety information
No data available

---

SECTION 10: Stability and reactivity
Reactivity
No data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
No data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
In the event of fire: see section 5

---

SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
No data available
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitisation
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.

---

SECTION 12: Ecological information
Toxicity
No data available
Persistence and degradability
No data available
Bioaccumulative potential
No data available
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
No data available

---

SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

---

SECTION 14: Transport information
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
No data available

---

SECTION 15: Regulatory information
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
No data available
Chemical Safety Assessment
For this product a chemical safety assessment was not carried out

---

SECTION 16: Other information
Full text of H-Statements referred to under sections 2 and 3.
Acute Tox. Acute toxicity
H302 Harmful if swallowed.
Full text of R-phrases referred to under sections 2 and 3
Xn Harmful
R22 Harmful if swallowed.
Further information
Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

反应信息

• 作为反应物：
  描述：

  2-氨基-3-甲氧基吡啶 在 四丁基溴化铵 、 lithium perchlorate 作用下， 以 溶剂黄146 、 乙腈 为溶剂， 反应 8.0h， 生成 2-氨基-3-甲氧基-5-溴吡啶
  参考文献：
  名称：

  导向基团可在温和条件下实现吡啶的电化学选择性间溴化

  摘要：

  在不使用催化剂和氧化剂的情况下，开发了一种简便且可持续的电化学溴化方案。通过引入定位基团，吡啶衍生物的区域选择性可以在被控制的元利用廉价且安全的溴盐在室温下位上。以 28-95% 的产率获得了多种溴化吡啶衍生物，并且该反应可以很容易地以克级规模进行。通过结合安装和去除导向基团，可以验证吡啶间溴化的概念。

  DOI：

  10.1021/acs.joc.1c00923
• 作为产物：
  描述：

  3-甲氧基-2-硝基吡啶 在 氢气 、 一水合肼 作用下， 以 乙醇 为溶剂， 40.0 ℃ 、2.0 MPa 条件下， 反应 4.0h， 生成 2-氨基-3-甲氧基吡啶
  参考文献：
  名称：

  制备有序介孔-二氧化硅支撑的钌纳米粒子，用于通过转移加氢选择性还原功能化的硝基芳烃

  摘要：

  负载在MCM-41型介孔二氧化硅（Ru / OMS-IL）上的Ru纳米颗粒用作硝基芳烃选择性加氢的催化剂。Ru / OMS-IL在温和条件下对各种硝基芳烃的还原具有很高的活性和化学选择性。Ru / OMS-IL催化剂可以循环使用至少六次，而催化性能没有任何可观察到的损失。

  DOI：

  10.1002/ejoc.201701228

文献信息

• Highly chemoselective reduction of nitroarenes over non-noble metal nickel-molybdenum oxide catalysts
  作者：Haigen Huang、Xueguang Wang、Xu Li、Chenju Chen、Xiujing Zou、Weizhong Ding、Xionggang Lu

  DOI：10.1039/c6gc03141b

  日期：——

  Chemoselective reduction of nitroarenes is an important transformation for the production of arylamines, which are the primary intermediates in the synthesis of pharmaceuticals, agrochemicals and dyes. Heterogeneous non-noble metal nickel-molybdenum...

  硝基芳烃的化学选择性还原是生产芳胺的重要转变，芳胺是合成药物，农药和染料的主要中间体。非均质非贵金属镍钼合金
• FLAP MODULATORS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US20150259357A1

  公开（公告）日：2015-09-17

  The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R 1 , R 2 , R 3 , R 3 ′, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention

  本发明涉及式（I）的化合物，或其形式，其中环A，R1，R2，R3，R3'，L，W和V如本文所定义，可用作FLAP调节剂。该发明还涉及包含式（I）化合物的药物组合物。制备和使用式（I）化合物的方法也属于本发明的范围。
• Synthesis of new heterocyclic phenols : 8-hydroxy-imidazo [1,2-a] pyridine
  作者：R. Rydzkowski、D. Blondeau、H. Sliwa

  DOI：10.1016/s0040-4039(00)98839-7

  日期：1985.1

  compound has been achieved by condensation of 2-amino-3-hydroxy-pyridine with chloroacetaldehyde. Activation by the free phenolic hydroxyl allows preferential nitration of the pyridine ring, in marked contrast to the behavior of the related ethers which suffer electrophilic substitution on the imidazole moiety, as usual in the series.

  未知标题化合物的制备已经通过2-氨基-3-羟基吡啶与氯乙醛的缩合而实现。与系列中通常使用的在咪唑基团上发生亲电取代的相关醚的行为形成鲜明对比的是，游离酚羟基的活化使吡啶环优先进行硝化。
• 3-Substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design
  作者：Charlie Hollanders、Mathias Elsocht、Olivier Van der Poorten、Mouhamad Jida、Evelien Renders、Bert U. W. Maes、Steven Ballet

  DOI：10.1039/d1cc01701b

  日期：——

  3-substituted 2-isocyanopyridines as convertible isocyanides in Ugi four-component reactions. The N-(3-substituted pyridin-2-yl)amide Ugi products can be cleaved by amines, alcohols, and water with Zn(OAc)2 as a catalyst. In addition, the applicability of the method was demonstrated in constrained di-/tripeptides bearing acid and base sensitive protective groups obtained via Ugi-4CR post-condensation modifications

  我们报告了在 Ugi 四组分反应中使用 3-取代 2-异氰基吡啶作为可转化异氰化物。所述ñ - （3-取代的吡啶-2-基）酰胺的Ugi产物可以通过胺，醇，水和用Zn（OAc）裂解2作为催化剂。此外，该方法的适用性在通过Ugi-4CR 缩合后修饰获得的带有酸和碱敏感保护基团的受限二/三肽中得到证明。
• N-doped graphitic carbon-improved Co–MoO3 catalysts on ordered mesoporous SBA-15 for chemoselective reduction of nitroarenes
  作者：Haigen Huang、Xiangcheng Liang、Xueguang Wang、Yao Sheng、Chenju Chen、Xiujing Zou、Xionggang Lu

  DOI：10.1016/j.apcata.2018.04.024

  日期：2018.6

  promoting the dissociation of hydrazine molecule into the active H* species for the reduction of nitro groups. After the seventh cycle for reduction of 4-methoxylnitrobenzene, the 2%Co–MoO3/[email protected] showed little change in catalytic performance, textural properties, size and dispersion of metal species and valence states of elements, indicating high stability and recyclability.

  首先通过SBA-15负载的Co-Mo氧化物与1,10-菲咯啉的原位反应制备了有序介孔SBA-15负载的金属Co-MoO 3催化剂。所得的带有N掺杂碳（NC）的Co-MoO 3 / [受电子邮件保护的]催化剂在接近室温（30°C）的条件下，通过水合肼将乙醇中的各种官能化硝基芳烃选择性还原为相应的芳胺，表现出较高的催化活性和化学选择性。 ）。为了还原所有测试的底物（28个实例），催化剂可提供> 99％的转化率和> 99％的芳基胺选择性。Co-MoO 3 / [受电子邮件保护]的出色催化性能归因于Co- Nχ（C）-Mo通过表面CO-N之间的相互作用产生的活性位点χ（C）和的MoO 3个物种，促进肼分子的离解成活性H *物种硝基的还原。在第七次还原4-甲氧基硝基苯的循环后，2％Co-MoO 3 / [受电子邮件保护]的催化性能，织构性质，金属种类的大小和分散度以及元素的价态几乎没有变化，表明具有很高的稳定性和可回收性。