2-氨基-4,5-二氢-1,3-噻唑-4-酮盐酸盐 | 2192-06-5

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 中文名称: 2-氨基-4,5-二氢-1,3-噻唑-4-酮盐酸盐
• 中文别名: 噻唑
• 英文名称: 2-Amino-4-thiazolinone hydrochloride
• 英文别名: 2-aminothiazolin-4-one hydrochloride；2-amino-thiazol-4-one; hydrochloride；2-Amino-thiazol-4-on; Hydrochlorid；2-aminothiazoline-4-one-hydrochloride；2-aminothiazolin-4-one-hydrochloride；2-Aminothiazolinone hydrochloride；2-imino-1,3-thiazolidin-4-one;hydrochloride
• CAS: 2192-06-5
• 化学式: C₃H₄N₂OS*ClH
• 分子量: 152.605
• InChiKey: YBDFGIGPQKUYGW-UHFFFAOYSA-N

物化性质

• 熔点：
  >350 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.0
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  80.8
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R43
• 海关编码：
  2934100090
• 安全说明：
  S24/25
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302,H317,H319

SDS

Name:	2-Amino-4 5-dihydro-1 3-thiazol-4-one hydrochloride tech Material Safety Data Sheet
Synonym:
CAS:	2192-06-5

Section 1 - Chemical Product MSDS Name:2-Amino-4 5-dihydro-1 3-thiazol-4-one hydrochloride tech Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
2192-06-5	2-Amino-4,5-dihydro-1,3-thiazol-4-one		unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 2192-06-5: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C3H5ClN2OS
Molecular Weight: 152.61

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 2192-06-5 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Amino-4,5-dihydro-1,3-thiazol-4-one hydrochloride - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 2192-06-5: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 2192-06-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 2192-06-5 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  phosphorus (III) oxychloride 、 2-氨基-4,5-二氢-1,3-噻唑-4-酮盐酸盐 在 sodium acetate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-氨基-4-氯噻唑-5-甲醛
  参考文献：
  名称：

  Azo compounds having a 5-substituted-4-chlorothiazolyl-2-diazo component

  摘要：

  式为##STR1##的化合物，其中K是苯胺，α-萘胺，吡唑酮，氨基吡唑，吲哚，四氢喹啉，噻唑，苯酚，萘酚，吡啶或吡啶酮系列偶联组分的基团。R是--CHO，--CH.dbd.C（CN）--R.sub.1，--CH.dbd.CH--R.sub.2，--CH.dbd.C（NO.sub.2）--R.sub.3，--CH.dbd.NOH或--CN，其中R.sub.1是（C.sub.1-10烷氧羰基；（C.sub.1-10烷氧）羰基单取代为氯，溴，氰，羟基，C.sub.1-2烷氧，（C.sub.1-2烷基）羰酰氧或（C.sub.1-2烷氧）羰基；（C.sub.1-10烷氧）羰基双取代为羟基和氯或溴；（C.sub.3-8烯基）氧羰基；（C.sub.3-8氯代烯基）氧羰基；（C.sub.3-8溴代烯基）氧羰基；丙炔氧羰基；苄氧羰基；氯苄氧羰基；硝基苄氧羰基；C.sub.1-4烷基磺酰基；苯基磺酰基；甲苯基磺酰基；氨基甲酰基；（C.sub.1-2烷基）氨基甲酰基；二（C.sub.1-2烷基）氨基甲酰基；苯基氨基硫酰基；苯并咪唑基-2；氰基；乙酰基；苯基；苯甲酰基或苯基或苯甲酰基，其1，2或3个取代基各自独立地为氯，溴或硝基，最多只有两个硝基的限制，其中R.sub.2是苯基；苯甲酰基或苯基或苯甲酰基，其1，2或3个取代基各自独立地为氯，溴或硝基，最多只有两个硝基的限制，R.sub.3是氢，甲基或乙基，m为0或1，用作分散染料，用于染色和印刷由合成或半合成，亲水性，高分子量，有机材料制成或组成的纺织基材，如线性芳香族聚酯，纤维素21/2醋酸盐，纤维素三醋酸盐和合成聚酰胺，其中R为甲酰基也用于染色羊毛。

  公开号：

  US04505857A1
• 作为产物：
  描述：

  羧乙基异硫脲氯化物 以 丙酮 为溶剂， 以75%的产率得到2-氨基-4,5-二氢-1,3-噻唑-4-酮盐酸盐
  参考文献：
  名称：

  Lazarev; Ramsh; Ivanenko, Russian Journal of General Chemistry, 2000, vol. 70, # 3, p. 442 - 449

  摘要：

  DOI：

文献信息

• Synthesis and structure-activity relations of a series of antibacterially active 5-(5-nitro-2-furfurylidene)thiazolones, 5-(5-nitro-2-furylpropenylidene)thiazolones, and 6-(5-nitro-2-furyl)-4H-1,3-thiazinones
  作者：Eva B. Akerblom

  DOI：10.1021/jm00252a008

  日期：1974.6
• Sasaki, Pharmaceutical Bulletin, 1954, vol. 2, p. 123,126
  作者：Sasaki

  DOI：——

  日期：——
• Volhard, Journal fur praktische Chemie (Leipzig 1954), 1874, vol. <2>9, p. 29
  作者：Volhard

  DOI：——

  日期：——
• Lazarev; Ramsh; Ivanenko, Russian Journal of General Chemistry, 2000, vol. 70, # 3, p. 442 - 449
  作者：Lazarev、Ramsh、Ivanenko

  DOI：——

  日期：——
• Azo compounds having a 5-substituted-4-chlorothiazolyl-2-diazo component
  申请人：Sandoz Ltd.

  公开号：US04505857A1

  公开（公告）日：1985-03-19

  Compounds of the formula ##STR1## in which K is the radical of a coupling component of the aniline, .alpha.-naphthylamine, pyrazolone, aminopyrazole, indole, tetrahydroquinoline, thiazole, phenol, naphthol, pyridine or pyridone series. R is --CHO, --CH.dbd.C(CN)--R.sub.1, --CH.dbd.CH--R.sub.2, --CH.dbd.C(NO.sub.2)--R.sub.3, --CH.dbd.NOH or --CN, wherein R.sub.1 is (C.sub.1-10 alkoxycarbonyl; (C.sub.1-10 alkoxy)carbonyl monosubstituted by chloro, bromo, cyano, hydroxy, C.sub.1-2 alkoxy, (C.sub.1-2 alkyl)carbonyloxy or (C.sub.1-2 alkoxy)carbonyl; (C.sub.1-10 alkoxy)carbonyl disubstituted by hydroxy and by chloro or bromo; (C.sub.3-8 alkenyl)oxycarbonyl; (C.sub.3-8 chloroalkenyl)oxycarbonyl; (C.sub.3-8 bromoalkenyl)oxycarbonyl; propynyloxycarbonyl; benzyloxycarbonyl; chlorobenzyloxycarbonyl; nitrobenzyloxycarbonyl; C.sub.1-4 alkylsulfonyl; phenylsulfonyl; tolylsulfonyl; carbamoyl; (C.sub.1-2 alkyl)carbamoyl; di(C.sub.1-2 alkyl)carbamoyl; phenylcarbamoyl; aminothiocarbonyl; benzimidazolyl-2; cyano; acetyl; phenyl; benzoyl or phenyl or benzoyl substituted by 1, 2 or 3 substituents each of which is independently chloro, bromo or nitro, with the proviso that the maximum number of nitro groups is two, and R.sub.2 is phenyl; benzoyl or phenyl or benzoyl substituted by 1, 2 or 3 substituents each of which is independently chloro, bromo or nitro, with the proviso that the maximum number of nitro groups is two, and R.sub.3 is hydrogen, methyl or ethyl, and m is 0 or 1, useful as disperse dyes for dyeing and printing textile substrates comprising or consisting of synthetic or semi-synthetic, hydrophobic, high molecular weight, organic materials such as linear aromatic polyesters, cellulose 21/2 acetate, cellulose triacetate and synthetic polyamides, with those wherein R is formyl also being useful for dyeing wool.

  式为##STR1##的化合物，其中K是苯胺，α-萘胺，吡唑酮，氨基吡唑，吲哚，四氢喹啉，噻唑，苯酚，萘酚，吡啶或吡啶酮系列偶联组分的基团。R是--CHO，--CH.dbd.C（CN）--R.sub.1，--CH.dbd.CH--R.sub.2，--CH.dbd.C（NO.sub.2）--R.sub.3，--CH.dbd.NOH或--CN，其中R.sub.1是（C.sub.1-10烷氧羰基；（C.sub.1-10烷氧）羰基单取代为氯，溴，氰，羟基，C.sub.1-2烷氧，（C.sub.1-2烷基）羰酰氧或（C.sub.1-2烷氧）羰基；（C.sub.1-10烷氧）羰基双取代为羟基和氯或溴；（C.sub.3-8烯基）氧羰基；（C.sub.3-8氯代烯基）氧羰基；（C.sub.3-8溴代烯基）氧羰基；丙炔氧羰基；苄氧羰基；氯苄氧羰基；硝基苄氧羰基；C.sub.1-4烷基磺酰基；苯基磺酰基；甲苯基磺酰基；氨基甲酰基；（C.sub.1-2烷基）氨基甲酰基；二（C.sub.1-2烷基）氨基甲酰基；苯基氨基硫酰基；苯并咪唑基-2；氰基；乙酰基；苯基；苯甲酰基或苯基或苯甲酰基，其1，2或3个取代基各自独立地为氯，溴或硝基，最多只有两个硝基的限制，其中R.sub.2是苯基；苯甲酰基或苯基或苯甲酰基，其1，2或3个取代基各自独立地为氯，溴或硝基，最多只有两个硝基的限制，R.sub.3是氢，甲基或乙基，m为0或1，用作分散染料，用于染色和印刷由合成或半合成，亲水性，高分子量，有机材料制成或组成的纺织基材，如线性芳香族聚酯，纤维素21/2醋酸盐，纤维素三醋酸盐和合成聚酰胺，其中R为甲酰基也用于染色羊毛。