tert-butyl N-[2-(5-bromo-2-oxo-1-pyridyl)ethyl]carbamate | 1051315-89-9

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tert-butyl N-[2-(5-bromo-2-oxo-1-pyridyl)ethyl]carbamate
• 英文别名: tert-butyl 2-(5-bromo-2-oxopyridin-1(2H)-yl)ethylcarbamate；tert-butyl N-[2-(5-bromo-2-oxopyridin-1-yl)ethyl]carbamate
• CAS: 1051315-89-9
• 化学式: C₁₂H₁₇BrN₂O₃
• 分子量: 317.183
• InChiKey: GRLZDSPGPPBLPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[2-(5-bromo-2-oxo-1-pyridyl)ethyl]carbamate 在 bis-triphenylphosphine-palladium(II) chloride 、 potassium acetate 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 26.0h， 生成 tert-butyl N-[2-[2-oxo-5-[2-[4-(pentafluorosulfanyl)phenoxy]-3-pyridyl]-1-pyridyl]ethyl]carbamate
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS OF USE THEREOF
  [FR] COMPOSÉS ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating diseases. Specific diseases include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

  公开号：

  WO2023146512A1
• 作为产物：
  描述：

  2-羟基-5-溴吡啶 、 N-Boc-溴乙胺 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以33 %的产率得到tert-butyl N-[2-(5-bromo-2-oxo-1-pyridyl)ethyl]carbamate
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS OF USE THEREOF
  [FR] COMPOSÉS ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating diseases. Specific diseases include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

  公开号：

  WO2023146512A1

文献信息

• Nitrogen-Containing heterocyclyl ketones and methods of use
  申请人：Albrecht Brian K.

  公开号：US20080280917A1

  公开（公告）日：2008-11-13

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于预防和治疗HGF介导的疾病等疾病有效。本发明涵盖了新型化合物、类似物、前药和其药学上可接受的盐、制药组合物以及预防和治疗涉及癌症等疾病和其他疾病或病况的方法。本发明还涉及制造这种化合物的过程，以及在这些过程中有用的中间体。
• Nitrogen-containing heterocyclyl ketones and methods of use
  申请人：Amgen Inc.

  公开号：US08314087B2

  公开（公告）日：2012-11-20

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于预防和治疗诸如HGF介导的疾病等疾病有效。本发明涵盖了新型化合物、类似物、前药及其药学上可接受的盐、制药组合物和预防和治疗涉及癌症等疾病和其他疾病或状况的方法。本发明还涉及制备这种化合物的过程以及在这种过程中有用的中间体。
• WO2008/103277
  申请人：——

  公开号：——

  公开（公告）日：——
• US8314087B2
  申请人：——

  公开号：US8314087B2

  公开（公告）日：2012-11-20
• [EN] NITROGEN-CONTAINING HETEROCYCLYL KETONES AND METHODS OF USE<br/>[FR] CÉTONES D'HÉTÉROCYCLYLE CONTENANT DE L'AZOTE ET PROCÉDÉS D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2008103277A2

  公开（公告）日：2008-08-28

  [EN] Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
  [FR] L'invention concerne des composés sélectionnés efficaces dans la prophylaxie et le traitement de maladies, par exemple des maladies médiées par HGF. L'invention concerne de nouveaux composés, analogues, promédicaments et sels acceptables d'un point de vue pharmaceutique de ceux-ci, des compositions pharmaceutiques et des méthodes prophylactiques et thérapeutiques utilisées dans des maladies ou des états pathologiques tels que le cancer et analogues. L'invention concerne également des procédés de fabrication desdits composés, ainsi que des intermédiaires utilisés dans lesdits procédés.