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2-氨基-4-(对硝基苯)噻唑 | 2104-09-8

分子结构分类

有机化合物 - 苯类化合物 - 苯和取代衍生物

中文名称

2-氨基-4-(对硝基苯)噻唑

中文别名

4-(4-硝基苯基)噻唑-2-基胺；4-(4-硝基苯基)噻唑-2-胺；4-(4-硝基苯基)-1,3-噻唑-2-胺

英文名称

4-(4-nitro-phenyl)-thiazol-2-ylamine

英文别名

4-(4-nitrophenyl)thiazol-2-amine；4-(4-nitrophenyl)-1,3-thiazol-2-amine；2-amino-4-(p-nitrophenyl)thiazole；2-amino-4-(4-nitrophenyl)thiazole；4-(p-nitrophenyl)-2-aminothiazole；2-amino-4-(4'-nitrophenyl)-1,3-thiazole；4-(4-nitrophenyl)thiazole-2-amine

CAS

2104-09-8

化学式

C₉H₇N₃O₂S

mdl

MFCD00170222

分子量

221.239

InChiKey

RIKJWJIWXCUKQV-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

熔点：

283-287 °C
沸点：

231°C (rough estimate)
密度：

1.4086 (rough estimate)

计算性质

辛醇/水分配系数(LogP)：

2.4
重原子数：

15
可旋转键数：

1
环数：

2.0
sp3杂化的碳原子比例：

0.0
拓扑面积：

113
氢给体数：

1
氢受体数：

5

安全信息

危险等级：

IRRITANT
危险品标志：

Xi
危险类别码：

R22,R36/37/38
海关编码：

2934100090
WGK Germany：

3
储存条件：

库房应保持通风、低温和干燥的环境。

SDS

SDS：0d76a419dbd26dbae83b135ebed51630

查看

Material Safety Data Sheet

Section 1. Identiﬁcation of the substance
Product Name: 4-(4-Nitrophenyl)-1,3-thiazol-2-amine
Synonyms:

Section 2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.
H302: Harmful if swallowed
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

Section 3. Composition/information on ingredients.
Ingredient name: 4-(4-Nitrophenyl)-1,3-thiazol-2-amine
CAS number: 2104-09-8

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section 5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels, refrigerated.

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
Appearance: Not speciﬁed
No data
Boiling point:
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C9H7N3O2S
Molecular weight: 221.2

Section 10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

Section 11. Toxicological information
No data.

Section 12. Ecological information
No data.

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
Non-harzardous for air and ground transportation.

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

类别：有毒物品
毒性分级：低毒
急性毒性：口服-大鼠 LD50: 14200 毫克/公斤
刺激数据：眼睛-兔子 500 毫克/24 小时轻度
可燃性危险特性：可燃；燃烧产生有毒氮氧化物和硫氧化物烟雾
储运特性：库房通风、低温干燥
灭火剂：干粉、泡沫、砂土、二氧化碳、雾状水

上下游信息

下游产品

中文名称	英文名称	CAS号	化学式	分子量
[4-(4-硝基苯基)-1,3-噻唑-2-基]肼	2-hydrazino-4-(p-nitrophenyl)thiazole	26049-70-7	C₉H₈N₄O₂S	236.254
2-叠氮基-4-(4-硝基苯基)-1,3-噻唑	2-Azido-4-p-nitrophenylthiazol	62263-03-0	C₉H₅N₅O₂S	247.237
4-(4-氨基苯基)-2-氨基噻唑	4-(4-aminophenyl)thiazol-2-amine	3673-53-8	C₉H₉N₃S	191.257
——	N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]acetamide	53101-19-2	C₁₁H₉N₃O₃S	263.277
——	2-chloroacetamido-4-p-nitrophenylthiazole	37614-91-8	C₁₁H₈ClN₃O₃S	297.722
——	2-bromoacetylamino-4-(4-nitrophenyl)thiazole	37614-94-1	C₁₁H₈BrN₃O₃S	342.173
4-(4-乙酰氨基苯基)-2-氨基噻唑	N-(4-(2-aminothiazol-4-yl)phenyl)acetamide	21674-96-4	C₁₁H₁₁N₃OS	233.294
——	ethyl N-(4-p-nitrophenyl-2-thiazolyl)carbamate	83758-18-3	C₁₂H₁₁N₃O₄S	293.303
——	3-chloro-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]propanamide	——	C₁₂H₁₀ClN₃O₃S	311.749
——	2-Ethylamino-N-[4-(4-nitro-phenyl)-thiazol-2-yl]-acetamide	91402-01-6	C₁₃H₁₄N₄O₃S	306.345
——	2-((2-((4-(4-nitrophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetic acid	406470-92-6	C₁₃H₁₁N₃O₅S₂	353.379
——	2,2,2-trichloroethyl N-(4-p-nitrophenyl-2-thiazolyl)carbamate	83758-12-7	C₁₂H₈Cl₃N₃O₄S	396.638
4-吗啉乙酰胺,N-[4-(4-硝基苯基)-2-噻唑基]-	2-(morpholinoacetamido)-4-p-nitrophenylthiazole	105602-45-7	C₁₅H₁₆N₄O₄S	348.382
——	4-N,6-N-bis(4-nitrophenyl)-2-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,5-triazine-2,4,6-triamine	1258254-41-9	C₂₄H₁₆N₁₀O₆S	572.52
2-氨基-5-硝基-4-(对硝基苯基)噻唑	2-amino-5-nitro-4-(p-nitrophenyl)thiazole	102300-80-1	C₉H₆N₄O₄S	266.237
——	4-N,6-N-bis(4-fluorophenyl)-2-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,5-triazine-2,4,6-triamine	1258254-43-1	C₂₄H₁₆F₂N₈O₂S	518.506
——	4-N,6-N-bis(4-bromophenyl)-2-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,5-triazine-2,4,6-triamine	1258254-42-0	C₂₄H₁₆Br₂N₈O₂S	640.317
——	1-[4-(4-Nitrophenyl)-1,3-thiazol-2-yl]-3-(phenylcarbamothioylamino)urea	1220352-99-7	C₁₇H₁₄N₆O₃S₂	414.469
——	4-N,6-N-bis(4-chlorophenyl)-2-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,5-triazine-2,4,6-triamine	1258254-44-2	C₂₄H₁₆Cl₂N₈O₂S	551.415
——	1-[(4-Methylphenyl)carbamothioylamino]-3-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]urea	1220352-96-4	C₁₈H₁₆N₆O₃S₂	428.495
——	N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]furan-2-carboxamide	——	C₁₄H₉N₃O₄S	315.309
——	N-[4-(4-nitro-phenyl)-thiazol-2-yl]-N'-phenyl-[1,3,4]thiadiazole-2,5-diamine	1220352-79-3	C₁₇H₁₂N₆O₂S₂	396.453
——	N-[5-formyl-4-(4-nitrophenyl)-1,3-thiazol-2-yl]acetamide	——	C₁₂H₉N₃O₄S	291.287
——	1-[(4-Methoxyphenyl)carbamothioylamino]-3-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]urea	1220352-98-6	C₁₈H₁₆N₆O₄S₂	444.495
——	4-N,6-N-bis(3-chloro-4-fluorophenyl)-2-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,5-triazine-2,4,6-triamine	1258254-40-8	C₂₄H₁₄Cl₂F₂N₈O₂S	587.396
——	1-[(2-Methylphenyl)carbamothioylamino]-3-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]urea	1220352-95-3	C₁₈H₁₆N₆O₃S₂	428.495
——	N-(4-methylphenyl)-N'-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,4-thiadiazole-2,5-diamine	1220352-76-0	C₁₈H₁₄N₆O₂S₂	410.48
2-叠氮-5-硝基-4-(4-硝基苯基)-1,3-噻唑	2-azido-5-nitro-4-(4-nitro-phenyl)-thiazole	62263-04-1	C₉H₄N₆O₄S	292.235
——	5-chloro-N-(4-(4-nitrophenyl)thiazol-2-yl)thiophene-2-carboxamide	——	C₁₄H₈ClN₃O₃S₂	365.821
——	N-(4-methoxyphenyl)-N'-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,4-thiadiazole-2,5-diamine	1220352-78-2	C₁₈H₁₄N₆O₃S₂	426.48
——	1-[(2-Methoxyphenyl)carbamothioylamino]-3-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]urea	1220352-97-5	C₁₈H₁₆N₆O₄S₂	444.495
——	N-(2-methylphenyl)-N'-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,4-thiadiazole-2,5-diamine	1220352-75-9	C₁₈H₁₄N₆O₂S₂	410.48

反应信息

作为反应物：

描述：

2-氨基-4-(对硝基苯)噻唑在乙酸酐作用下，以水为溶剂，生成 N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]acetamide

参考文献：

名称：

Imidazole azo dyes

摘要：

一种包含至少一种具有以下结构的染料的摄影记录材料 ##STR1## 其中D是必需的原子团，用于完成至少含有一个氮原子的5元环，A是氢、烷基、烷氧基、苯基、烷硫基、氰基、硝基或卤素，n为0至3，R.sub.1是氢、烷基、羟基、酰胺基，R.sub.6是氢或未取代或取代的氨基，R.sub.4是氢或烷氧基。该材料以良好的色彩复制、鲜艳的颜色和出色的耐光性而著称。

公开号：

US04743683A1