4-N,6-N-bis(4-nitrophenyl)-2-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,5-triazine-2,4,6-triamine | 1258254-41-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-N,6-N-bis(4-nitrophenyl)-2-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,5-triazine-2,4,6-triamine
• CAS: 1258254-41-9
• 化学式: C₂₄H₁₆N₁₀O₆S
• 分子量: 572.52
• InChiKey: DRXZPQQJAYIOHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  253
• 氢给体数：
  3
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  4-硝基苯胺 在 碳酸氢钠 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 丙酮 为溶剂， 反应 13.5h， 生成 4-N,6-N-bis(4-nitrophenyl)-2-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-1,3,5-triazine-2,4,6-triamine
  参考文献：
  名称：

  Synthesis and antibacterial evaluation of series of novel tri-substituted-s-triazine derivatives

  摘要：

  Two novel series of s-triazine derivatives (6a-e and 7a-f) were synthesized with various aromatic and heterocyclic amines. The synthesized compounds were subsequently evaluated for their in vitro antibacterial activity against three gram-positive viz. Bacillus subtilis (NCIM-2063), Bacillus cereus (NCIM-2156), Staphylococcus aureus (NCIM-2079) and gram-negative bacteria viz. Pseudomonas aeruginosa (NCIM-2036), Escherichia coli (NCIM-2065) and Klebseilla pneumoniae (NCIM-2706) by the broth dilution method as recommended by the National Committee for Clinical Laboratory Standards (NCCLS) using streptomycin as reference standard. Structures of the synthesized compounds were elucidated on the basis of elemental analyses and spectral data.

  DOI：

  10.1007/s00044-010-9446-7

文献信息

• Synthesis and antibacterial evaluation of series of novel tri-substituted-s-triazine derivatives
  作者：Udaya Pratap Singh、Ramendra Kumar Singh、Hans Raj Bhat、Yadav Pankajkumar Subhashchandra、Vikas Kumar、Mukesh Kumar Kumawat、Prashant Gahtori

  DOI：10.1007/s00044-010-9446-7

  日期：2011.12

  Two novel series of s-triazine derivatives (6a-e and 7a-f) were synthesized with various aromatic and heterocyclic amines. The synthesized compounds were subsequently evaluated for their in vitro antibacterial activity against three gram-positive viz. Bacillus subtilis (NCIM-2063), Bacillus cereus (NCIM-2156), Staphylococcus aureus (NCIM-2079) and gram-negative bacteria viz. Pseudomonas aeruginosa (NCIM-2036), Escherichia coli (NCIM-2065) and Klebseilla pneumoniae (NCIM-2706) by the broth dilution method as recommended by the National Committee for Clinical Laboratory Standards (NCCLS) using streptomycin as reference standard. Structures of the synthesized compounds were elucidated on the basis of elemental analyses and spectral data.