5-(6-methoxy-quinolin-4-yl)-3-piperidin-4-yl-oxazolidin-2-one | 681278-28-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-(6-methoxy-quinolin-4-yl)-3-piperidin-4-yl-oxazolidin-2-one
• 英文别名: 5-(6-Methoxyquinolin-4-yl)-3-piperidin-4-yl-1,3-oxazolidin-2-one
• CAS: 681278-28-4
• 化学式: C₁₈H₂₁N₃O₃
• 分子量: 327.383
• InChiKey: DYDHAFIDCLRUEN-UHFFFAOYSA-N

物化性质

• 沸点：
  591.5±50.0 °C(Predicted)
• 密度：
  1.264±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  63.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(6-methoxy-quinolin-4-yl)-3-piperidin-4-yl-oxazolidin-2-one 在 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Oxazolidinones as novel human CCR8 antagonists

  摘要：

  High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.076
• 作为产物：
  描述：

  [R,S]-2-(6-methoxyquinolin-4-yl)oxirane 在 4-二甲氨基吡啶 、 lithium perchlorate 、 三氟乙酸 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 生成 5-(6-methoxy-quinolin-4-yl)-3-piperidin-4-yl-oxazolidin-2-one
  参考文献：
  名称：

  Oxazolidinones as novel human CCR8 antagonists

  摘要：

  High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.076

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004032856A2

  公开（公告）日：2004-04-22

  Oxazolidin-2-one of the formula as further defined herein are useful for inhibiting the chemokine receptor nominated CCR8, resulting in treatment of diseases such as asthma and the like.