Tachysterol(2) | 115-61-7

• 物质功能分类: 天然产物 - 甾体化合物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Tachysterol(2)
• 英文别名: 3-[(E)-2-[1-[(E)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-4-methylcyclohex-3-en-1-ol
• CAS: 115-61-7；21307-05-1；24945-48-0；137174-34-6
• 化学式: C₂₈H₄₄O
• 分子量: 396.657
• InChiKey: XQFJZHAVTPYDIQ-OKLKQMLOSA-N

物化性质

• 熔点：
  <25 °C
• 比旋光度：
  D18 -70° (24.6 mg in 2 ml petr ether); 18546 -86.3° (petr ether)
• 沸点：
  460.3°C (rough estimate)
• 密度：
  0.9784 (rough estimate)
• 溶解度：
  氯仿（少量溶解）、乙酸乙酯（少量溶解）、己烷（少量溶解）、甲醇（少量溶解）

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] IMIDAZOLIUM REAGENT FOR MASS SPECTROMETRY<br/>[FR] RÉACTIF D'IMIDAZOLIUM POUR SPECTROMÉTRIE DE MASSE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2021234004A1

  公开（公告）日：2021-11-25

  The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

  本发明涉及适用于质谱的化合物，以及利用该化合物进行分析物分子的质谱测定方法。
• [EN] REAGENT FOR MASS SPECTROMETRY<br/>[FR] RÉACTIF POUR SPECTROMÉTRIE DE MASSE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2020020849A1

  公开（公告）日：2020-01-30

  The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

  本发明涉及适用于质谱的试剂，以及利用所述试剂进行分析物分子的质谱测定方法。
• [EN] AN EFFICIENT METHOD FOR SYNTHESIS OF 5-(3-PYRIDYL)-2,2'-BITHIOPHENE(SENSITIZER)<br/>[FR] PROCÉDÉ EFFICACE POUR LA SYNTHÈSE DU 5-(3-PYRIDYL)-2,2'-BITHIOPHÈNE (SENSIBILISATEUR)
  申请人：FERMENTA BIOTECH LTD

  公开号：WO2021019558A1

  公开（公告）日：2021-02-04

  The present invention discloses an efficient process for synthesis of photosensitizer, 5-(3-pyridyl)-2,2'-bithiophene in high yield and purity.

  本发明公开了一种高效合成光敏剂5-(3-吡啶基)-2,2'-双噻吩的高产率和高纯度工艺。
• Efficient Process for Preparing Steroids and Vitamin D Derivatives With the Unnatural Configuration at C20 (20 Alpha-Methyl) from Pregnenolone
  申请人：Bridges Alexander James

  公开号：US20080171728A1

  公开（公告）日：2008-07-17

  Disclosed herein are methods for preparing steroids and Vitamin D derivatives having the unnatural beta (usually S) configuration at C20, the methods comprising the use of compounds of the formula: wherein R is as defined herein. Also disclosed are steroids and Vitamin D derivatives made using the methods disclosed herein and pharmaceutical compositions comprising said steroids and Vitamin D derivatives.

  本文披露了一种制备具有不寻常的β（通常为S）构型的C20处的类固醇和维生素D衍生物的方法，该方法包括使用以下式的化合物：其中R如本文所定义。还披露了使用本文披露的方法制备的类固醇和维生素D衍生物，以及包含该类固醇和维生素D衍生物的药物组合物。
• Ultraviolet irradiation apparatus for photochemical reaction and preparation process of vitamin D derivative making use of the same
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：US20040108198A1

  公开（公告）日：2004-06-10

  Disclosed herein are an ultraviolet irradiation apparatus for photochemical reactions which can irradiate the photo-reactive solution with ultraviolet rays having a specific wavelength suitable for the intended photochemical reaction at a high efficiency, and a process by which a provitamin D derivative can be converted into a provitamin D derivative at a high efficiency by means of a photochemical reaction by one-step process of light irradiation, thereby preparing a vitamin D derivative at a high efficiency. The ultraviolet irradiation apparatus irradiates the photo-reactive solution with the ultraviolet rays having the specific wavelength through a quartz rod. Specifically, the apparatus is constructed by an electric discharge lamp, a condensing and reflecting mirror and a plane mirror both having wavelength selective property, an optical filter which transmits the ultraviolet rays having the specific wavelength, and a quartz rod on which the ultraviolet rays having the specific wavelength are struck. The photo-reactive solution is irradiated with the ultraviolet rays from the quartz rod. The quartz rod is immersed in the photo-reactive solution, or a reaction vessel is irradiated with the ultraviolet rays from the quartz rod. In the preparation process of the vitamin D derivative, an ultraviolet irradiation apparatus for photochemical reactions having an ultraviolet radiation-emitting lamp, an optical system having wavelength selective property and a quartz rod on which the ultraviolet rays having the specific wavelength from the optical system are struck is used, and a solution of a provitamin D derivative is irradiated with the ultraviolet rays having the specific wavelength emitted from the quartz rod to cause a photochemical reaction of the provitamin D derivative solution, thereby forming a previtamin D derivative. The previtamin D derivative is further subjected to a thermal isomerization reaction to prepare the vitamin D derivative.

  本文披露了一种用于光化学反应的紫外辐射装置，该装置可以以高效率照射具有特定波长的紫外线的光敏反应溶液，适用于预期的光化学反应，并通过光照的一步法将一种类维生素D衍生物转化为高效率的类维生素D衍生物的过程，从而高效率地制备维生素D衍生物。紫外辐射装置通过石英棒以特定波长的紫外线照射光敏反应溶液。具体而言，该装置由电放电灯、具有波长选择性的聚焦和反射镜和平面镜、透射具有特定波长的紫外线的光学滤波器以及被特定波长的紫外线击中的石英棒构成。光敏反应溶液从石英棒处照射出紫外线。石英棒浸泡在光敏反应溶液中，或者光敏反应溶液从石英棒处照射到反应容器中。在维生素D衍生物的制备过程中，使用一种用于光化学反应的紫外辐射装置，该装置具有紫外辐射发射灯、具有波长选择性的光学系统和石英棒，光学系统发出具有特定波长的紫外线，用于照射类维生素D衍生物溶液，从而引发类维生素D衍生物溶液的光化学反应，形成前维生素D衍生物。进一步对前维生素D衍生物进行热异构化反应，制备维生素D衍生物。