Glycine, N-2-pyrimidinyl-, methyl ester | 1042503-63-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Glycine, N-2-pyrimidinyl-, methyl ester
• 英文别名: methyl 2-(pyrimidin-2-ylamino)acetate
• CAS: 1042503-63-8
• 化学式: C₇H₉N₃O₂
• 分子量: 167.167
• InChiKey: MXOZQKREESQWKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Glycine, N-2-pyrimidinyl-, methyl ester 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 生成 N-(pyrimidin-2-yl)glycine
  参考文献：
  名称：

  Basic techniques of working on a solid phase: From ABC of the peptide synthesis to libraries of non-natural amino acids

  摘要：

  Libraries of hardly available amino acids bearing a heteroaromatic ring (2-pyrimidyl, substituted 2-pyridyl or 2-thiazolyl) at the amino group were prepared using solid-phase synthesis on various resins. The synthesized compounds are structurally similar to some known antidiabetic drugs. The paper combines features of a review (elementary introduction to the solid-phase synthesis methodology and technique for beginners and selected methods from peptide chemistry) and step-by-step experimental protocols (tested by the authors) useful as a methodic tool. The presented protocols (immobilization and modification of amino acids, placing and removal of common protective groups) require no sophisticated equipment and may be useful as pictorial introductory tasks for students education.

  DOI：

  10.1134/s107036321012025x
• 作为产物：
  描述：

  BOC-甘氨酸 、 sodium methylate 、 2-甲砜基嘧啶 在 caesium carbonate 、 sodium iodide 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 、 二氯甲烷 为溶剂， 反应 12.5h， 以85%的产率得到Glycine, N-2-pyrimidinyl-, methyl ester
  参考文献：
  名称：

  Basic techniques of working on a solid phase: From ABC of the peptide synthesis to libraries of non-natural amino acids

  摘要：

  Libraries of hardly available amino acids bearing a heteroaromatic ring (2-pyrimidyl, substituted 2-pyridyl or 2-thiazolyl) at the amino group were prepared using solid-phase synthesis on various resins. The synthesized compounds are structurally similar to some known antidiabetic drugs. The paper combines features of a review (elementary introduction to the solid-phase synthesis methodology and technique for beginners and selected methods from peptide chemistry) and step-by-step experimental protocols (tested by the authors) useful as a methodic tool. The presented protocols (immobilization and modification of amino acids, placing and removal of common protective groups) require no sophisticated equipment and may be useful as pictorial introductory tasks for students education.

  DOI：

  10.1134/s107036321012025x

文献信息

• Basic techniques of working on a solid phase: From ABC of the peptide synthesis to libraries of non-natural amino acids
  作者：E. V. Babaev、D. S. Ermolat’ev

  DOI：10.1134/s107036321012025x

  日期：2010.12

  Libraries of hardly available amino acids bearing a heteroaromatic ring (2-pyrimidyl, substituted 2-pyridyl or 2-thiazolyl) at the amino group were prepared using solid-phase synthesis on various resins. The synthesized compounds are structurally similar to some known antidiabetic drugs. The paper combines features of a review (elementary introduction to the solid-phase synthesis methodology and technique for beginners and selected methods from peptide chemistry) and step-by-step experimental protocols (tested by the authors) useful as a methodic tool. The presented protocols (immobilization and modification of amino acids, placing and removal of common protective groups) require no sophisticated equipment and may be useful as pictorial introductory tasks for students education.