O-(pent-4-en-1-yl)hydroxylamine hydrochloride | 1417456-05-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-(pent-4-en-1-yl)hydroxylamine hydrochloride
• 英文别名: O-(pent-4-en-1-yl)hydroxylamine；O-pent-4-enylhydroxylamine;hydrochloride
• CAS: 1417456-05-3
• 化学式: C₅H₁₁NO*ClH
• 分子量: 137.609
• InChiKey: HFTKVLUVHLVBPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.26
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,4'-二羟基二苯甲酮 、 O-(pent-4-en-1-yl)hydroxylamine hydrochloride 以 乙醇 为溶剂， 以78%的产率得到bis(4-hydroxyphenyl)methanone O-pent-4-en-1-yl oxime
  参考文献：
  名称：

  Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism

  摘要：

  In this study, a series of bis(4-hydroxy) benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have additional and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2016.01.089
• 作为产物：
  描述：

  5-溴-1-戊烯 在 碳酸氢钠 、 肼 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 22.0h， 生成 O-(pent-4-en-1-yl)hydroxylamine hydrochloride
  参考文献：
  名称：

  [EN] METHODS FOR POST-FABRICATION FUNCTIONALIZATION OF POLY(ESTER UREAS)
  [FR] PROCÉDÉS POUR LA FONCTIONNALISATION DE POLY(ESTER-URÉES) APRÈS FABRICATION

  摘要：

  基于氨基酸的聚（酯脲）（PEU）作为一类聚合物正在成为再生医学应用中显示出潜力的材料。发明的实施例涉及合成携带修饰酪氨酸氨基酸上“可点击”基团的PEU。这些基团包括炔基、叠氮基、烯烃、酪氨酸酚和酮基团。通过界面缩聚方法获得了分子量超过100k Da的PEU，并通过共聚合改变基团的浓度。使用1H核磁共振和紫外-可见光谱方法证明了可衍生功能的结合。电纺技术用于制备直径在350纳米至500纳米范围内的PEU纳米纤维。这些纳米纤维基质具有适用于组织工程的机械强度（杨氏模量：30045 MPa；拉伸应力：8.51.2 MPa）。在电纺后，一系列生物活性肽和荧光分子通过生物正交反应结合到纳米纤维表面。

  公开号：

  WO2015048728A1

文献信息

• New and Concise Syntheses of the Bicyclic Oxamazin Core Using an Intramolecular Nitroso Diels–Alder Reaction and Ring-Closing Olefin Metathesis
  作者：Kyle D. Watson、Serena Carosso、Marvin J. Miller

  DOI：10.1021/ol303305u

  日期：2013.1.18

  making an unsaturated bicyclic oxamazin core are reported. The first involves the use of an intramolecular Diels–Alder reaction to form both of the fused rings in one step. The second approach incorporates ring-closing olefin metathesis in the final step to form the second fused ring of the core. The scope of the second approach was also expanded further to afford larger ringed bicyclic systems.

  本文报道了两种新的、简洁的合成方法，用于制备不饱和双环 oxamazin 核。第一个涉及使用分子内 Diels-Alder 反应在一个步骤中形成两个稠环。第二种方法在最后一步结合闭环烯烃复分解，以形成核心的第二个稠环。第二种方法的范围也进一步扩大，以提供更大的环状双环系统。
• [EN] POLYMERIC STRUCTURES CONTAINING STRAINED CYCLOALKYNE FUNCTIONALITY FOR POST-FABRICATION AZIDEALKYNE CYCLOADDITION FUNCTIONALIZATION<br/>[FR] STRUCTURES POLYMÉRIQUES CONTENANT UNE FONCTIONNALITÉ CYCLOALCYNE CONTRAINTE POUR UNE FONCTIONNALISATION PAR CYCLOADDITION D'AZIDE-ALCYNE POST-FABRICATION
  申请人：UNIV AKRON

  公开号：WO2014022535A1

  公开（公告）日：2014-02-06

  A method of creating biocompatible polymeric structures includes the steps of: providing a biocompatible polymer including a strained cycloalkyne end group; forming a polymeric structure from the biocompatible polymer such that the strained cycloalkyne end group remains on the biocompatible polymer; providing an azide tethered molecule; and, after forming the polymeric structure, reacting the azide tethered molecule with the cycloalkyne in an azide alkyne cycloaddition reaction to further functionalize the polymeric structure.

  创建生物相容性聚合物结构的方法包括以下步骤：提供包含应变环己炔末端基团的生物相容性聚合物；从生物相容性聚合物中形成聚合物结构，使得应变环己炔末端基团保留在生物相容性聚合物上；提供一个连接了偶氮基团的分子；在形成聚合物结构后，将偶氮基团分子与环己炔进行偶氮炔环加成反应，以进一步功能化聚合物结构。
• POLYMERIC STRUCTURES CONTAINING STRAINED CYCLOALKYNE FUNCTIONALITY FOR POST-FABRICATION AZIDEALKYNE CYCLOADDITION FUNCTIONALIZATION
  申请人：Becker Matthew

  公开号：US20150197600A1

  公开（公告）日：2015-07-16

  A method of creating biocompatible polymeric structures includes the steps of: providing a biocompatible polymer including a strained cycloalkyne end group; forming a polymeric structure from the biocompatible polymer such that the strained cycloalkyne end group remains on the biocompatible polymer; providing an azide tethered molecule; and, after forming the polymeric structure, reacting the azide tethered molecule with the cycloalkyne in an azide alkyne cycloaddition reaction to further functionalize the polymeric structure.

  创建生物相容性高分子结构的方法包括以下步骤：提供具有应变环己烯末端基团的生物相容性高分子；从生物相容性高分子中形成高分子结构，使得应变环己烯末端基团保留在生物相容性高分子上；提供一个带有偶氮基团的分子；在形成高分子结构后，将偶氮基团与环己烯进行偶氮烷基环加成反应，以进一步功能化高分子结构。
• US9587070B2
  申请人：——

  公开号：US9587070B2

  公开（公告）日：2017-03-07
• [EN] METHODS FOR POST-FABRICATION FUNCTIONALIZATION OF POLY(ESTER UREAS)<br/>[FR] PROCÉDÉS POUR LA FONCTIONNALISATION DE POLY(ESTER-URÉES) APRÈS FABRICATION
  申请人：BECKER MATTHEW

  公开号：WO2015048728A1

  公开（公告）日：2015-04-02

  Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent "clickable" groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with Mw exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 30045 MPa; tensile stress: 8.51.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aqueous media.

  基于氨基酸的聚（酯脲）（PEU）作为一类聚合物正在成为再生医学应用中显示出潜力的材料。发明的实施例涉及合成携带修饰酪氨酸氨基酸上“可点击”基团的PEU。这些基团包括炔基、叠氮基、烯烃、酪氨酸酚和酮基团。通过界面缩聚方法获得了分子量超过100k Da的PEU，并通过共聚合改变基团的浓度。使用1H核磁共振和紫外-可见光谱方法证明了可衍生功能的结合。电纺技术用于制备直径在350纳米至500纳米范围内的PEU纳米纤维。这些纳米纤维基质具有适用于组织工程的机械强度（杨氏模量：30045 MPa；拉伸应力：8.51.2 MPa）。在电纺后，一系列生物活性肽和荧光分子通过生物正交反应结合到纳米纤维表面。