4,7,7-trimethyl-2-oxa-bicyclo[2.2.1]heptan-3-one | 54812-08-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 4,7,7-trimethyl-2-oxa-bicyclo[2.2.1]heptan-3-one
• 英文别名: 4,7,7-trimethyl-2-oxa-norbornan-3-one；4,7,7-Trimethyl-2-oxa-norbornan-3-on；Camphonolsaeure-lacton；4,7,7-Trimethyl-2-oxabicyclo[2.2.1]heptan-3-one
• CAS: 54812-08-7
• 化学式: C₉H₁₄O₂
• 分子量: 154.209
• InChiKey: JBJFGGILWWLCGE-UHFFFAOYSA-N

物化性质

• 沸点：
  226.5±8.0 °C(Predicted)
• 密度：
  1.056±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,7,7-trimethyl-2-oxa-bicyclo[2.2.1]heptan-3-one 、 硝酸 生成 (+-)-camphoronic acid
  参考文献：
  名称：

  Bredt, Journal fur praktische Chemie (Leipzig 1954), 1911, vol. <2> 83, p. 403 Anm. 3

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 4,7,7-trimethyl-2-oxa-bicyclo[2.2.1]heptan-3-one
  参考文献：
  名称：

  Bredt, Journal fur praktische Chemie (Leipzig 1954), 1913, vol. <2> 87, p. 8

  摘要：

  DOI：

文献信息

• Compositions and methods for the treatment of disease associated with Trp-p8 expression
  申请人：Natarajan K. Sateesh

  公开号：US20050054651A1

  公开（公告）日：2005-03-10

  Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

  提供了小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物，以及用于识别和表征新型小分子Trp-p8调节剂的方法，以及用于降低Trp-p8表达细胞的存活能力和/或抑制生长的方法，用于激活Trp-p8介导的阳离子流入的方法，用于刺激凋亡和/或坏死的方法，以及用于治疗疾病的相关方法，包括肺癌、乳腺癌、结肠癌和/或前列腺癌等癌症，以及与Trp-p8表达相关的其他疾病，如良性前列腺增生。
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION
  申请人：Natarajan Sateesh K.

  公开号：US20120094977A1

  公开（公告）日：2012-04-19

  Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

  提供了小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物，以及用于识别和表征新型小分子Trp-p8调节剂的方法，以及用于降低Trp-p8表达细胞的存活率和/或抑制生长的方法，用于激活Trp-p8介导的阳离子流入的方法，用于刺激凋亡和/或坏死的方法，以及相关的治疗疾病的方法，包括肺癌、乳腺癌、结肠癌和/或前列腺癌等癌症，以及与Trp-p8表达相关的其他疾病，例如良性前列腺增生等。
• Bactericidal antimicrobial methods and compositions for use in treating gram positive infections
  申请人：Influx, Inc.

  公开号：US20030225126A1

  公开（公告）日：2003-12-04

  The present invention relates generally to the field of bacteriology. More particularly, the present invention provides methods and compositions for increasing the effectiveness of existing antibacterial agents and methods of overcoming bacterial resistance. Specifically, the invention provides methods of enhancing the action of an antibacterial agent by use of an antibiotic potentiator. Compositions of antibiotic potentiators including an acyl hydrazide, an oxy amide, and an 8-hydroxy quinoline also are disclosed.

  本发明一般涉及细菌学领域。更具体地说，本发明提供了提高现有抗菌剂有效性的方法和组合物，以及克服细菌耐药性的方法。具体来说，本发明提供了通过使用抗生素增效剂来增强抗菌剂作用的方法。本发明还公开了包括酰肼、氧酰胺和 8-羟基喹啉在内的抗生素增效剂组合物。
• Substituted 2-pyrrolidine-2-yl-1H-indole compounds
  申请人：Sundermann Corinna

  公开号：US20050014815A1

  公开（公告）日：2005-01-20

  Novel 2-pyrrolidin-2-yl- 1 H-indole compounds corresponding to formula (I) wherein R 1 , R 2 , R 3 and R 4 have the meanings given in the description, and pharmaceutical compositions containing these compounds, as well as processes for the preparation of such compounds and intermediate products of this process, and related methods of treatment.

  新型 2-吡咯烷-2-基-1-吡咯烷酮 1 对应于式(I)的新型 2-吡咯烷-2-基-1-H-吲哚化合物 其中 R 1 , R 2 , R 3 和 R 4 的含义，以及含有这些化合物的药物组合物、制备这些化合物的工艺和该工艺的中间产品，以及相关的处理方法。
• Bredt, Journal fur praktische Chemie (Leipzig 1954), 1913, vol. <2> 87, p. 8
  作者：Bredt

  DOI：——

  日期：——