6-[(4-Oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraene-5-carbonyl)amino]hexyl 3-(3-carbazol-9-ylpropoxy)-5-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]benzoate | 839709-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-[(4-Oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraene-5-carbonyl)amino]hexyl 3-(3-carbazol-9-ylpropoxy)-5-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]benzoate
• 英文别名: 6-[(4-oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraene-5-carbonyl)amino]hexyl 3-(3-carbazol-9-ylpropoxy)-5-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]benzoate
• CAS: 839709-83-0
• 化学式: C₅₀H₅₆N₄O₈
• 分子量: 841.017
• InChiKey: SDHZCIIQEVXVBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  62
• 可旋转键数：
  19
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  6-[(4-Oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraene-5-carbonyl)amino]hexyl 3-(3-carbazol-9-ylpropoxy)-5-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]benzoate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 3-Aminomethyl-5-(3-carbazol-9-yl-propoxy)-benzoic acid 6-[(10-oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carbonyl)-amino]-hexyl ester
  参考文献：
  名称：

  Molecular Tripods Showing Fluorescence Enhancement upon Binding to Streptavidin

  摘要：

  We introduce a new approach to biotin-streptavidin assays based on a molecular tripod which consists of biotin, a fluorophore, and a quencher. The interaction between streptavidin and molecular tripods perturbs the ground-state quencher-fluorophore dimeric conformation in the absence of streptavidin and diminishes the intrinsic self-quenching of a quencher-fluorophore pair. The emission intensity of the molecular tripods plus streptavidin is 3.5-5.2 times that of molecular tripods in the absence of streptavidin.

  DOI：

  10.1021/ol047801h
• 作为产物：
  描述：

  5-羟基间苯二甲酸 在 palladium on activated charcoal 4-二甲氨基吡啶 、 sodium hydroxide 、 lithium aluminium tetrahydride 、 sodium azide 、 2-氯-1-甲基吡啶碘化物 、 氢气 、 potassium carbonate 、 三乙胺 、 N,N-二异丙基乙胺 、 potassium iodide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 乙酸乙酯 、 丙酮 、 乙腈 为溶剂， 生成 6-[(4-Oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraene-5-carbonyl)amino]hexyl 3-(3-carbazol-9-ylpropoxy)-5-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]benzoate
  参考文献：
  名称：

  Molecular Tripods Showing Fluorescence Enhancement upon Binding to Streptavidin

  摘要：

  We introduce a new approach to biotin-streptavidin assays based on a molecular tripod which consists of biotin, a fluorophore, and a quencher. The interaction between streptavidin and molecular tripods perturbs the ground-state quencher-fluorophore dimeric conformation in the absence of streptavidin and diminishes the intrinsic self-quenching of a quencher-fluorophore pair. The emission intensity of the molecular tripods plus streptavidin is 3.5-5.2 times that of molecular tripods in the absence of streptavidin.

  DOI：

  10.1021/ol047801h

文献信息

• Molecular Tripods Showing Fluorescence Enhancement upon Binding to Streptavidin
  作者：Tae Woo Kim、Hey Young Yoon、Jung-hyun Park、Oh-Hoon Kwon、Du-Jeon Jang、Jong-In Hong

  DOI：10.1021/ol047801h

  日期：2005.1.1

  We introduce a new approach to biotin-streptavidin assays based on a molecular tripod which consists of biotin, a fluorophore, and a quencher. The interaction between streptavidin and molecular tripods perturbs the ground-state quencher-fluorophore dimeric conformation in the absence of streptavidin and diminishes the intrinsic self-quenching of a quencher-fluorophore pair. The emission intensity of the molecular tripods plus streptavidin is 3.5-5.2 times that of molecular tripods in the absence of streptavidin.