hydroquinone glucuronide | 35119-91-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: hydroquinone glucuronide
• 英文别名: quinol glucuronide；(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-hydroxyphenoxy)oxane-2-carboxylic acid
• CAS: 35119-91-6
• 化学式: C₁₂H₁₄O₈
• 分子量: 286.238
• InChiKey: KCWGTTYNHQOGSJ-GOVZDWNOSA-N

物化性质

• 沸点：
  626.3±55.0 °C(Predicted)
• 密度：
  1.697±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  对苯二酚 、 uridine-5'-diphospho-α-D-glucuronic acid trisodium salt 在 eicosaethylene glycol hexadecyl ether 、 Sprague-Dawley rat liver microsomes 、 magnesium chloride 作用下， 以 水 为溶剂， 反应 17.0h， 生成 hydroquinone glucuronide
  参考文献：
  名称：

  Urinary Excretion of Arbutin Metabolites after Oral Administration of Bearberry Leaf Extracts

  摘要：

  本研究开发并验证了一种高效液相色谱法，可荧光检测尿液中的熊果苷代谢物对苯二酚葡萄糖醛酸苷（2）和对苯二酚硫酸盐（6）。甲基熊果苷 (4) 和 6 是作为参考物质合成的。化合物 2 是利用大鼠肝脏微粒体的葡萄糖基转移酶系统从对苯二酚和尿苷 5′-二磷酸葡萄糖醛酸中酶解制备的，并通过两次液-液萃取和一次固相萃取进行富集。通过紫外光谱和荧光光谱、高效液相色谱-质谱法以及酶水解对苯二酚法，确定了纯化产物的主要成分化合物 2 (5)。在口服推荐治疗剂量的熊果叶提取物后，尿液中 2、5 和 6 的浓度水平与预期浓度范围一致。在对 3 名志愿者进行的初步药代动力学研究中，研究人员调查了他们在摄入含有德国 E 委员会推荐剂量熊果苷的熊果叶水提取物后，熊果苷代谢物 2、5 和 6 随时间变化的肾脏排泄情况。在第三名受试者中，这种代谢物的排泄量达到了熊果苷给药总量的 5.6%。初步的药代动力学结果证实，预计肾脏不会排出毒性临界浓度的代谢物 5。

  DOI：

  10.1055/s-2005-837782

文献信息

• EXTRACT POWDER OF INDIGO PLANT, AND ITS PREPARATION AND USES
  申请人：Fujii Mitsukiyo

  公开号：US20100034757A1

  公开（公告）日：2010-02-11

  The present invention has objects to provide an extract powder of indigo plant, which has a relatively low hygroscopicity, satisfactory fluidability, and improved storage stability; a process thereof; and a composition incorporated with the extract powder. The objects are solved by a process for producing an extract powder of indigo plant, which comprises incorporating a partial starch hydrolyzate with a dextrose equivalent of 10.2 or lower into one part by weight, on a dry solid basis, of an indigo plant extract contained in a liquid extract of indigo plant in an amount of not lower than 0.25 part by weight but not higher than 5 parts by weight, on a dry solid basis, and drying the resulting mixture; an extract powder of indigo plant prepared thereby; and a composition incorporated with the extract powder.

  本发明旨在提供一种靛蓝植物的提取粉末，其具有相对较低的吸湿性、满意的流动性和改善的储存稳定性；其制备方法；以及与提取粉末混合的组合物。通过将DE值为10.2或更低的部分淀粉水解物以不低于0.25份重量但不高于5份重量的干固物基础加入到液态提取的靛蓝植物提取物的一份重量中，并将所得混合物干燥，来解决上述问题；由此制备的靛蓝植物提取粉末；以及与提取粉末混合的组合物。
• EXTERNAL DERMAL COMPOSITION FOR ANTI-AGEING AND METHOD FOR PRODUCING THE SAME
  申请人：HAYASHIBARA CO., LTD.

  公开号：US20150342854A1

  公开（公告）日：2015-12-03

  The present invention has an object to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as wrinkles, fine wrinkles, blemishes, and saggings caused by increasing age or ageing; and maintains or improves the barrier function and the hyaluronic acid production in the skin. The object is solved by providing an external dermal composition for anti-ageing, which contains an aqueous medium as a base material and one or more ingredients selected from L-ascorbic acid, derivatives thereof, and their salts as an effective ingredient(s).

  本发明的目的是提供一种用于抗衰老的外用皮肤组成物，该组成物可以预防或改善因年龄增长或衰老引起的皮肤问题，如皱纹、细纹、斑点和下垂，并维持或改善皮肤的屏障功能和透明质酸的产生。本发明通过提供一种外用皮肤组成物来实现该目的，该组成物包含水性介质作为基材料，并含有一种或多种从L-抗坏血酸、其衍生物和它们的盐中选择的成分作为有效成分。
• AGENT FOR EXTERNAL APPLICATION TO THE SKIN
  申请人：KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

  公开号：EP1894558A1

  公开（公告）日：2008-03-05

  The present invention has an object to provide an agent for suppressing melanin production and/or inhibiting elastase activity containing a plant extract as an effective substance with high safety and acceptable levels of stability and odor or sediment formation and an agent for external application to the skin comprising the above agent which has excellent effects in skin-whitening and skin-beautifying. The object is attained by providing an agent for external application to the skin containing indigo-plant extract.

  本发明的目的是提供一种抑制黑色素生成和/或抑制弹性蛋白酶活性的制剂，该制剂含有一种植物提取物作为有效物质，安全性高，稳定性和气味或沉淀物的形成水平可接受，并提供一种由上述制剂组成的皮肤外用制剂，该制剂在皮肤美白和皮肤美容方面具有极佳的效果。通过提供一种含有靛蓝植物提取物的皮肤外用制剂，可以达到上述目的。
• EXTRACT POWDER OF INDIGO-CONTAINING PLANT, METHOD FOR PRODUCTION THEREOF, AND USE THEREOF
  申请人：Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

  公开号：EP2087903A1

  公开（公告）日：2009-08-12

  The present invention has objects to provide an extract powder of indigo plant, which has a relatively low hygroscopicity, satisfactory fluidability, and improved storage stability; a process thereof; and a composition incorporated with the extract powder. The objects are solved by a process for producing an extract powder of indigo plant, which comprises incorporating a partial starch hydrolyzate with a dextrose equivalent of 10.2 or lower into one part by weight, on a dry solid basis, of an indigo plant extract contained in a liquid extract of indigo plant in an amount of not lower than 0.25 part by weight but not higher than 5 parts by weight, on a dry solid basis, and drying the resulting mixture; an extract powder of indigo plant prepared thereby; and a composition incorporated with the extract powder.

  本发明的目的是提供一种吸湿性相对较低、流动性令人满意、贮存稳定性更好的靛蓝植物提取物粉末；其工艺；以及掺入该提取物粉末的组合物。本发明的目的是通过一种生产蓝靛花提取物粉末的工艺来解决的，该工艺包括将葡萄糖当量为 10.2 或更低的部分淀粉水解物加入到蓝靛花液体提取物中所含的蓝靛花提取物中，以干固体为基础，加入量不低于 0.25 重量份，但不高于 5 重量份，并干燥所得混合物；由此制备蓝靛花提取物粉末；以及加入该提取物粉末的组合物。
• External dermal composition for anti-ageing and method for producing the same
  申请人：Hayashibara Co., Ltd.

  公开号：US10111822B2

  公开（公告）日：2018-10-30

  The present invention has an object to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as wrinkles, fine wrinkles, blemishes, and saggings caused by increasing age or ageing; and maintains or improves the barrier function and the hyaluronic acid production in the skin. The object is solved by providing an external dermal composition for anti-ageing, which contains an aqueous medium as a base material and one or more ingredients selected from L-ascorbic acid, derivatives thereof, and their salts as an effective ingredient(s).

  本发明的目的是提供一种用于抗衰老的外用真皮组合物，该组合物可预防或改善因年龄增长或老化引起的皱纹、细小皱纹、斑点和疤痕等明显的皮肤问题，并保持或改善皮肤的屏障功能和透明质酸的生成。本发明的目的是提供一种用于抗衰老的外用皮肤组合物，该组合物含有作为基质材料的水介质和作为有效成分的一种或多种选自 L-抗坏血酸、其衍生物及其盐类的成分。