2-氯-3-甲氧基-5-甲基吡啶 | 1203499-46-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-氯-3-甲氧基-5-甲基吡啶
• 英文名称: 2-Chloro-3-methoxy-5-methylpyridine
• CAS: 1203499-46-0
• 化学式: C₇H₈ClNO
• mdl: MFCD13563046
• 分子量: 157.6
• InChiKey: HNYOWJROVIRPCU-UHFFFAOYSA-N

物化性质

• 沸点：
  242.2±35.0 °C(Predicted)
• 密度：
  1.168±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• WGK Germany：
  3

文献信息

• TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF
  申请人：Merck Patent GmbH

  公开号：US20160376283A1

  公开（公告）日：2016-12-29

  The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

  本发明涉及式I化合物及其药用可接受的组合物，用作TBK/IKKε抑制剂。
• [EN] 2,4-DIAMINO-PYRIMIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE 2,4-DIAMINO-PYRIMIDINE
  申请人：ASTRAZENECA AB

  公开号：WO2009010794A1

  公开（公告）日：2009-01-22

  The invention concerns compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, Q, R3, and R4 are as defined in the description. The present invention also relates to processes for the preparation ofsuch compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4 kinases.

  本发明涉及式(I)化合物，或其药用可接受盐，其中R1、Q、R3和R4如描述中定义。本发明还涉及制备此类化合物的方法、包含它们的药物组合物以及它们在制造用作抗增殖剂的药物中的应用，用于预防或治疗对EphB4激酶抑制敏感的肿瘤或其他增殖性疾病。
• NOVEL PYRIMIDINE DERIVATIVES 965
  申请人：Barlaam Bernard Christophe

  公开号：US20090054428A1

  公开（公告）日：2009-02-26

  The invention concerns compounds of Formula I, or a pharmaceutically acceptable salt thereof, where R 1 , Q, R 3 , and R 4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4 kinases.

  该发明涉及公式I的化合物，或其药学上可接受的盐，其中R1，Q，R3和R4如描述中所定义。本发明还涉及制备这种化合物的方法，包含它们的制药组合物以及它们在制造用于作为抗增殖剂用于预防或治疗对EphB4激酶抑制敏感的肿瘤或其他增殖性疾病的药物的用途。
• US9988391B2
  申请人：——

  公开号：US9988391B2

  公开（公告）日：2018-06-05