pentyn-1-ol | 181878-28-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: pentyn-1-ol
• 英文别名: methyl butynol；Pentynol；pent-1-yn-1-ol
• CAS: 181878-28-4
• 化学式: C₅H₈O
• 分子量: 84.1179
• InChiKey: UKIUSKWWNRYHOO-UHFFFAOYSA-N

物化性质

• 沸点：
  144.3±23.0 °C(Predicted)
• 密度：
  0.915±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  pentyn-1-ol 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以75%的产率得到4-pentyn-1-al
  参考文献：
  名称：

  Direct Access to Highly Enantioenriched α-Branched Acrylonitriles through a One-Pot Sequential Asymmetric Michael Addition/Retro-Dieckmann/Retro-Michael Fragmentation Cascade

  摘要：

  A highly enantioselective synthesis of alpha-branched acrylonitriles is reported featuring a one-pot sequential asymmetric Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. The method, which relies on a solid, bench-stable, and commercially available acrylonitrile surrogate, is practical, scalable, and highly versatile and provides a direct access to a wide range of enantioenriched nitrite-containing building blocks. Most importantly, the method offers a new tool to incorporate an acrylonitrile moiety in an asymmetric fashion.

  DOI：

  10.1021/acs.orglett.0c02079

文献信息

• N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
  申请人：Texas Biotechnology Corp.

  公开号：US06342610B2

  公开（公告）日：2002-01-29

  Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

  提供了噻吩基、呋喃基和吡咯基磺酰胺以及用于调节或改变内皮素肽家族活性的方法。特别是，提供了N-(异恶唑基)噻吩磺酰胺、N-(异恶唑基)呋喃磺酰胺和N-(异恶唑基)吡咯磺酰胺以及使用这些磺酰胺通过将受体与磺酰胺接触来抑制内皮素肽与内皮素受体结合的方法。还提供了通过施用有效量的一个或多个这些磺酰胺或其前药来治疗内皮素介导的疾病的方法，这些磺酰胺或其前药抑制或增加内皮素的活性。
• [EN] PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING OR PREVENTING A RESPIRATORY SYNCYTIAL VIRUS INFECTION<br/>[FR] DÉRIVÉS DE PYRIMIDINE ET LEUR UTILISATION DANS LE TRAITEMENT OU LA PRÉVENTION D'UNE INFECTION PAR LE VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：REVIRAL LTD

  公开号：WO2018025043A1

  公开（公告）日：2018-02-08

  Pyrimidine derivatives of formula (I) wherein: Z is a direct bond or -(CH2)n- wherein n is 1 or 2; one of X and Y is N, CH or CF, and the other of X and Y is CH; one of R1 and R2 is selected from -NHR, -NR2, -OR, -SR, -S(O)R, -S(O)2R and a group of the following formula (A) and the other of R1 and R2 is selected from -NHR', -OH, -OR' and a group of the above formula (A); R is unsubstituted C1-C6 alkyl; R' is a group selected from C1-C6 alkyl, 5- to 12-membered aryl and C3-C6 cycloalkyl, which group is unsubstituted or substituted; W is -(CH2)m-, -CH2-O-CH2-, -CH2-S-CH2- or -CH2-S(O)2-CH2-; p is 1, q is an integer of 1 - 6 and V is N; or p is 1, q is 0 and V is CH; or p is 0, q is 0 and V is N; r is 0 or 1; and R3 is -(CH2)s-NH2 or -(CH2)s-OH wherein s is 0 or an integer of 1 to 4; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

  式(I)的嘧啶衍生物，其中：Z是直接键或-(CH2)n-，其中n为1或2；X和Y中的一个是N、CH或CF，另一个是CH；R1和R2中的一个选自-NHR、-NR2、-OR、-SR、-S(O)R、-S(O)2R和下式(A)的基团，另一个选自-NHR'、-OH、-OR'和上述式(A)的基团；R为未取代的C1-C6烷基；R'为选自C1-C6烷基、5至12成员芳基和C3-C6环烷基的基团，该基团未取代或取代；W为-(CH2)m-、-CH2-O-CH2-、-CH2-S-CH2-或-CH2-S(O)2-CH2-；p为1，q为1至6的整数，V为N；或p为1，q为0，V为CH；或p为0，q为0，V为N；r为0或1；R3为-(CH2)s-NH2或-(CH2)s-OH，其中s为0或1至4的整数；及其药学上可接受的盐是RSV的抑制剂，因此可用于治疗或预防RSV感染。
• A Simple Nickel Catalyst Enabling an <i>E</i> ‐Selective Alkyne Semihydrogenation
  作者：Niklas O. Thiel、Benyapa Kaewmee、Trung Tran Ngoc、Johannes F. Teichert

  DOI：10.1002/chem.201903850

  日期：2020.2.3

  Stereoselective alkyne semihydrogenations are attractive approaches to alkenes, which are key building blocks for synthesis. With regards to the most atom‐economic reducing agent dihydrogen (H2), only few catalysts for the challenging E‐selective alkyne semihydrogenation have been disclosed, each with a unique substrate scope profile. Here, we show that a commercially available nickel catalyst facilitates

  立体选择性炔烃半氢化是制备烯烃的有吸引力的方法，烯烃是合成的关键组成部分。对于最具原子经济性的还原剂二氢（H 2 ），仅公开了少数用于具有挑战性的E-选择性炔烃半氢化的催化剂，每种催化剂都具有独特的底物范围特征。在这里，我们表明，市售的镍催化剂促进了多种取代内炔的E-选择性炔烃半氢化。这产生了一个简单且广泛适用的整体方案，用于使用 H 2立体选择性地访问E-烯烃，这可以作为通用的合成方法。
• Process for the preparation of ethylenic carbonyl compounds
  申请人：Rhone-Poulenc Sante

  公开号：US04749814A1

  公开（公告）日：1988-06-07

  Ethylenic carbonyl compounds of formula ##STR1## are made by the isomerization of acetylenic alcohols of formula ##STR2## in the presence of a catalyst consisting of a titanium derivative, a copper or silver derivative, and, if required, an acid, which may be in the form of an ester or anhydride, or an inorganic ester.

  化学式为##STR1##的乙烯羰基化合物是通过在存在钛衍生物、铜或银衍生物以及必要时的酸催化剂的情况下，将化学式为##STR2##的乙炔醇异构化而成的，该酸可以是酯或酐形式，或者是无机酯。
• Antagonists of gonadotropin releasing hormone
  申请人：Merck & Co., Inc.

  公开号：US05849764A1

  公开（公告）日：1998-12-15

  There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

  已披露化合物的化学式(I) ##STR1## 及其药用可接受的盐，可用作GnRH拮抗剂，因此可能对男性和女性的各种性激素相关和其他疾病的治疗有用。