2-(2-hydroxyphenyl)quinoline N-oxide | 72195-26-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(2-hydroxyphenyl)quinoline N-oxide
• 英文别名: 2-(2-hydroxyphenyl)quinoline-N-oxide；2-(1-oxy-quinolin-2-yl)-phenol；2-(o-Hydroxyphenyl)-chinolin-1-oxid
• CAS: 72195-26-7
• 化学式: C₁₅H₁₁NO₂
• 分子量: 237.258
• InChiKey: LFYWDLFSHJIBIE-UHFFFAOYSA-N

物化性质

• 熔点：
  180.3-181.0 °C
• 沸点：
  444.0±37.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.85
• 重原子数：
  18.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.17
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  (E)-2'-hydroxy-2-nitrochalcone 在 palladium on activated charcoal ammonium formate 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以36%的产率得到2-(2-hydroxyphenyl)quinoline N-oxide
  参考文献：
  名称：

  一锅法合成2-（2-羟基芳基）喹啉：2'-羟基-2-硝基查耳酮的还原偶联反应

  摘要：

  通过在酸性介质（HCl / AcOH）中由氯化亚锡诱导的2'-羟基-2-硝基查耳酮的分子内还原偶联反应，已经开发出了一锅合成新型2-（2-羟基芳基）喹啉的方法。在某些情况下，可以用甲酸铵/钯-碳在甲醇中进行这些转化。

  DOI：

  10.1016/s0040-4039(03)01374-1

文献信息

• CHROMOPHORIC POLYMER DOTS WITH NARROW-BAND EMISSION
  申请人：University of Washington through its Center for Commercialization

  公开号：US20140350183A1

  公开（公告）日：2014-11-27

  Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.

  本文提供了聚合物、单体、色团聚合物点及相关方法。提供了具有窄带发射的高荧光色团聚合物点。还提供了合成色团聚合物的方法、形成色团聚合物点的制备方法以及利用窄带发射的独特性质进行生物应用的方法。
• ENCODED CHROMOPHORIC POLYMER PARTICLES
  申请人：University of Washington through its Center for Commercialization

  公开号：EP3521399A1

  公开（公告）日：2019-08-07

  The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.

  本公开提供了可对分析物进行光学和/或生物分子编码的编码发色性聚合物颗粒。本公开还提供了包含多个编码发色性聚合物颗粒的悬浮液。本公开还提供了使用编码发色性聚合物颗粒的方法以及使用编码发色性聚合物颗粒进行多重分析的系统。
• Chromophoric polymer dots with narrow-band emission
  申请人：University of Washington through its Center for Commercialization

  公开号：US10150841B2

  公开（公告）日：2018-12-11

  Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.

  提供了聚合物、单体、发色聚合物点及相关方法。提供了具有窄带发射的高荧光发色性聚合物点。此外，还提供了发色性聚合物的合成方法、形成发色性聚合物点的制备方法以及利用窄带发射独特性质的生物应用。
• Encoded chromophoric polymer particles and methods of use thereof
  申请人：University of Washington through its Center for Commercialization

  公开号：US10444243B2

  公开（公告）日：2019-10-15

  The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.

  本公开提供了可对分析物进行光学和/或生物分子编码的编码发色性聚合物颗粒。本公开还提供了包含多个编码发色性聚合物颗粒的悬浮液。本公开还提供了使用编码发色性聚合物颗粒的方法以及使用编码发色性聚合物颗粒进行多重分析的系统。
• Reductive Coupling Reactions of 2-Nitrochalcones and their β-Hydroxy-analogues: New Syntheses of 2-Arylquinoline and 2-Aryl-4-hydroxyquinoline Derivatives
  作者：Ana I. R. N. A. Barros、André F. R. Dias、Artur M. S. Silva

  DOI：10.1007/s00706-007-0647-9

  日期：2007.6

  A one-pot synthesis of novel 2-arylquinolines and 2-aryl-4-hydroxyquinolines was developed from the intramolecular reductive coupling reactions of 2-nitrochalcones and 3-hydroxy-1-phenyl-3-(2-nitrophenyl)-2-propen-1-ones. Depending on the reduction method and on the presence of electron donating substituents on the A ring of 2-nitrochalcones one can modulate the formation of 2-arylquinolines, their N-oxides, and of 2-aminochalcones. The reduction of 3-hydroxy-1-(2-hydroxyphenyl)-3-(2-nitrophenyl)-2-propen-1-ones with stannous chloride in hydrochloric acid gave 2 '-aminoflavones and with ammonium formate and Pd/C yielded 2-(2-hydroxyaryl)-4-hydroxyquinolines.