2,3,5-Trimethoxybenzoyl chloride | 119098-79-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,5-Trimethoxybenzoyl chloride
• CAS: 119098-79-2
• 化学式: C₁₀H₁₁ClO₄
• 分子量: 230.648
• InChiKey: CAACINBBYQUTRH-UHFFFAOYSA-N

物化性质

• 沸点：
  346.9±37.0 °C(Predicted)
• 密度：
  1.227±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3,5-Trimethoxybenzoyl chloride 在 盐酸 、 palladium on activated charcoal 氢氧化钾 、 lithium aluminium tetrahydride 、 氯化亚砜 、 氢气 、 potassium carbonate 、 magnesium 、 三氟乙酸酐 、 碘甲烷 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 92.0h， 生成 (2',4,6,6'-tetramethoxy-2,4-dimethyl-1,1'-biphenyl-3,3'-diyl)-bisethanone
  参考文献：
  名称：

  Rizzacase, Mark A.; Sargent, Melvyn V., Journal of the Chemical Society. Perkin transactions I, 1988, p. 2425 - 2428

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3,5-三甲氧基苯甲酸 在 氯化亚砜 作用下， 反应 20.0h， 生成 2,3,5-Trimethoxybenzoyl chloride
  参考文献：
  名称：

  Rizzacase, Mark A.; Sargent, Melvyn V., Journal of the Chemical Society. Perkin transactions I, 1988, p. 2425 - 2428

  摘要：

  DOI：

文献信息

• Regioselectively substituted cellulose esters
  申请人：Eastman Chemical Company

  公开号：US11136414B2

  公开（公告）日：2021-10-05

  The present application discloses regioselectively substituted cellulose esters, films made from the regioselectively substituted cellulose esters and methods for making the same. The regioselectively substituted cellulose esters are synthesized using trifluoroacetic anhydride and cellulose with various acyl donors or acyl donor precursors.

  本申请公开了区域选择性取代的纤维素酯、由区域选择性取代的纤维素酯制成的薄膜以及制作方法。调节选择性取代的纤维素酯是用三氟乙酸酐和纤维素与各种酰基供体或酰基供体前体合成的。
• Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents
  作者：Siavosh Mahboobi、Herwig Pongratz、Harald Hufsky、Jörg Hockemeyer、Markus Frieser、Alexei Lyssenko、Dietrich H. Paper、Jutta Bürgermeister、Frank-D. Böhmer、Heinz-Herbert Fiebig、Angelika M. Burger、Silke Baasner、Thomas Beckers

  DOI：10.1021/jm010940+

  日期：2001.12.1

  A new class of simple synthetic antimitotic compounds based on 2-aroylindoles was discovered. (5-Methoxy-1H-2-indolyl)-phenylmethanone (1) as well as analogous 3-fluorophenyl- (36) and 3-methoxyphenyl (3) derivatives displayed high cytotoxicity Of IC50 = 20 to 75 nM against the human HeLa/KB cervical, SK-OV-3 ovarian, and U373 astrocytoma carcinoma cell lines. The inhibition of proliferation correlated with the arrest in the G2/M phase of the cell cycle. In in vitro assays with tubulin isolated from bovine brain, in general antiproliferative activity correlated with inhibition of tubulin polymerization. Thus, the antimitotic activity of 2-aroylindoles is explained by interference with the mitotic spindle apparatus and destabilization of microtubules. In contrast to colchicine, vincristine, nocodazole, or taxol, I did not significantly affect the GTPase activity of beta -tubulin. Interestingly, selected compounds inhibited angiogenesis in the chorioallantoic membrane (CAM) assay. In xenograft experiments, 1 was highly active after oral administration at 200 mg/kg against the human amelanocytic melanoma MEXF 989 in athymic nude mice. We conclude, that 2-aroylindoles constitute an interesting new class of antitubulin agents with the potential to be clinically developed for cancer treatment.
• REGIOSELECTIVELY SUBSTITUTED CELLULOSE ESTERS
  申请人：Eastman Chemical Company

  公开号：EP3601369A1

  公开（公告）日：2020-02-05
• US5175172A
  申请人：——

  公开号：US5175172A

  公开（公告）日：1992-12-29
• US7875631B2
  申请人：——

  公开号：US7875631B2

  公开（公告）日：2011-01-25