5,6-dimethoxy-3-(3,4,5-trimethoxy-phenylthio)-1H-indole-2-carboxylic acid methyl ester | 874797-21-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5,6-dimethoxy-3-(3,4,5-trimethoxy-phenylthio)-1H-indole-2-carboxylic acid methyl ester
• 英文别名: methyl 5,6-dimethoxy-3-(3,4,5-trimethoxyphenyl)sulfanyl-1H-indole-2-carboxylate
• CAS: 874797-21-4
• 化学式: C₂₁H₂₃NO₇S
• 分子量: 433.482
• InChiKey: IRGPDBWEENZUJV-UHFFFAOYSA-N

物化性质

• 熔点：
  164-168 °C(Solv: ethanol (64-17-5))
• 沸点：
  598.3±50.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  5,6-dimethoxy-3-(3,4,5-trimethoxy-phenylthio)-1H-indole-2-carboxylic acid methyl ester 在 lithium hydroxide 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-benzo[1,3]dioxol-5-ylmethyl-5,6-dimethoxy-3-(3,4,5-trimethoxy-phenylsulfanyl)-1H-indole-2-carboxylic acid
  参考文献：
  名称：

  1-benzyl-3-thioaryl-2-carboxyindoles as potent non-peptide endothelin antagonists

  摘要：

  Endothelin-1 is a potent vasoconstrictor which is thought to be involved in many human disease states. We have developed a series of indole non-peptide endothelin antagonists which display nanomolar receptor affinity. The representative compound from this series is PD 159433 (22), an ET(A) selective antagonist with an IC50 of 2 nM. The discovery, synthesis and structure-activity relationships of this series of compounds are described. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00232-6
• 作为产物：
  描述：

  5,6-二甲氧基吲哚-2-甲酸 在 sodium hydride 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 5,6-dimethoxy-3-(3,4,5-trimethoxy-phenylthio)-1H-indole-2-carboxylic acid methyl ester
  参考文献：
  名称：

  1-benzyl-3-thioaryl-2-carboxyindoles as potent non-peptide endothelin antagonists

  摘要：

  Endothelin-1 is a potent vasoconstrictor which is thought to be involved in many human disease states. We have developed a series of indole non-peptide endothelin antagonists which display nanomolar receptor affinity. The representative compound from this series is PD 159433 (22), an ET(A) selective antagonist with an IC50 of 2 nM. The discovery, synthesis and structure-activity relationships of this series of compounds are described. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00232-6

文献信息

• [EN] ARYLTHIOINDOLE TUBULIN POLYMERIZATION INHIBITORS AND METHODS OF TREATING OR PREVENTING CANCER USING SAME<br/>[FR] INHIBITEURS DE LA POLYMERISATION DE LA TUBULINE DE TYPE ARYLTHIOINDOLE, ET PROCEDES POUR TRAITER OU PREVENIR UN CANCER AU MOYEN DE CES INHIBITEURS
  申请人：HUMAN SERVICES GOVERNMENT OF T

  公开号：WO2006041961A1

  公开（公告）日：2006-04-20

  The present invention features arylthioindole compounds, pharmaceutical compositions of arylthioindole compounds and methods of treating a patient suffering from cancer or inflammatory, cardiac, or helminthic diseases, the method comprising administering to a patient one or more arylthioindole compounds of the invention.

  本发明涉及芳基硫代吲哚化合物，芳基硫代吲哚化合物的药物组合物以及治疗患有癌症或炎症、心脏病或寄生虫病的患者的方法，该方法包括向患者施用本发明的一种或多种芳基硫代吲哚化合物。
• New Arylthioindoles:  Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies
  作者：Gabriella De Martino、Michael C. Edler、Giuseppe La Regina、Antonio Coluccia、Maria Chiara Barbera、Denise Barrow、Robert I. Nicholson、Gabriela Chiosis、Andrea Brancale、Ernest Hamel、Marino Artico、Romano Silvestri

  DOI：10.1021/jm050809s

  日期：2006.2.1

  Arylthioindoles (ATIs) that possess a 3-methoxyphenylthio or a 3,5-dimethoxyphenylthio moiety at position 2 of the indole ring were effective tubulin assembly inhibitors, but weak inhibitors of MCF-7 cell growth. ATIs bearing a 3-(3,4,5-trimethoxyphenyl)thio moiety were potent tubulin polymerization inhibitors, with IC(50)s in the 2.0 (35) to 4.5 (37) mu M range. They also inhibited MCF-7 cell growth at nanomolar concentrations. The 3,4,5-trimethoxy substituted ATIs showed potencies comparable to those of the reference compounds colchicine and combretastatin A-4 in both tubulin assembly and cell growth inhibition assays. Dynamics simulation studies correlate well with the observed experimental data. Furthermore, from careful analysis of the biological and in silico data, we can now hypothesize a basic pharmacophore for this class of compounds.