2-氯-6-乙氧基-3-喹啉甲腈 | 937672-26-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 2-氯-6-乙氧基-3-喹啉甲腈
• 英文名称: 2-chloro-6-ethoxyquinoline-3-carbonitrile
• CAS: 937672-26-9
• 化学式: C₁₂H₉ClN₂O
• mdl: MFCD09035791
• 分子量: 232.669
• InChiKey: DLSJCLCHOALFAO-UHFFFAOYSA-N

物化性质

• 沸点：
  404.8±40.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  45.9
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933499090
• WGK Germany：
  3
• 危险标志：
  GHS05,GHS06
• 危险性描述：
  H301,H318
• 危险性防范说明：
  P280,P301 + P310,P305 + P351 + P338

反应信息

• 作为反应物：
  描述：

  2-氯-6-乙氧基-3-喹啉甲腈 在 盐酸 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 乙醇 、 二氯甲烷 为溶剂， 反应 51.0h， 生成 2-(1,4-diazepan-1-yl)-6-ethoxyquinoline-3-carbonitrile dihydrochloride
  参考文献：
  名称：

  Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases

  摘要：

  DOI：

  10.1021/acs.jmedchem.2c02068

文献信息

• [EN] METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION<br/>[FR] METHODES ET COMPOSITIONS PERMETTANT DE STIMULER LA NEUROGENESE ET D'INHIBER LA DEGENERESCENCE NEURONALE
  申请人：NEURONASCENT INC

  公开号：WO2007035722A3

  公开（公告）日：2007-07-19
• METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION
  申请人：Neuronascent, Inc.

  公开号：EP1937252A2

  公开（公告）日：2008-07-02
• COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION
  申请人：Neuronascent, Inc.

  公开号：EP1937252B1

  公开（公告）日：2017-10-25
• Methods and Compositons for Stimulating Neurogenesis and Inhibiting Neuronal Degeneration
  申请人：Kelleher-Andersson Judith

  公开号：US20080234253A1

  公开（公告）日：2008-09-25

  The present invention provides methods and compositions comprising compounds useful for stimulating neurogenesis. The methods and compositions comprising compounds are also useful for inhibiting neuronal degeneration. Thus, the present invention can be used in the treatment of diseases and conditions characterized by neuronal loss and reduced neurogenesis including Alzheimer's disease, stroke, traumatic brain injury, and depression. This invention could also be used for research products including single agents or mixtures of agents to promote, proliferate, differentiate, or maintain neurons from stem or progenitor cells.
• Methods and Compositions For Stimulating Neurogenesis and Inhibiting Neuronal Degeneration
  申请人：Neuronascent, Inc.

  公开号：US20150209371A1

  公开（公告）日：2015-07-30

  The present invention provides methods and compositions comprising compounds useful for stimulating neurogenesis. The methods and compositions comprising compounds are also useful for inhibiting neuronal degeneration. Thus, the present invention can be used in the treatment of diseases and conditions characterized by neuronal loss and reduced neurogenesis including Alzheimer's disease, stroke, traumatic brain injury, and depression. This invention could also be used for research products including single agents or mixtures of agents to promote, proliferate, differentiate, or maintain neurons from stem or progenitor cells.