4-ethynylpropiophenone | 170020-98-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-ethynylpropiophenone
• 英文别名: 1-(4-Ethynylphenyl)-1-propanone；1-(4-ethynylphenyl)propan-1-one
• CAS: 170020-98-1
• 化学式: C₁₁H₁₀O
• 分子量: 158.2
• InChiKey: YGUXMDKGKHZCJA-UHFFFAOYSA-N

物化性质

• 沸点：
  258.9±23.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-ethynylpropiophenone 、 三异丙基硅烷 在 Au₉₇Ag₃ 、 氧气 作用下， 以 甲苯 为溶剂， 反应 18.0h， 以90%的产率得到ethyl 4-((triisopropylsilyl)ethynyl)benzoate
  参考文献：
  名称：

  纳米孔金催化剂催化末端炔烃与氢硅烷的化学选择性好氧交叉脱氢偶联

  摘要：

  在O 2气氛下，存在纳米多孔金催化剂的情况下，末端炔烃与氢硅烷之间发生了需氧交叉脱氢反应。以高至高的产率合成了多种炔基硅烷，催化剂易于回收并重复使用多次。此外，通过该催化体系实现了炔醇的末端乙炔在羟基上的化学选择性直接甲硅烷基保护。

  DOI：

  10.1002/chem.201803874

文献信息

• Highly stereoselective synthesis of <i>trans</i>-alkenes <i>via</i> electrochemical Ni-catalyzed hydroarylation of alkynes with aryl iodides
  作者：Haoxiang Zhang、Lin Guo、Chao Yang、Wujiong Xia

  DOI：10.1039/d3ob00705g

  日期：——

  An electrochemical nickel catalyzed hydroarylation reaction of various alkynes is herein described. In this reaction, alkynes were coupled with aryl iodides by electrochemical Ni catalysis to obtain highly selective trans-olefins. The outstanding features of this protocol include mild reaction conditions, operational simplicity, and excellent functional group tolerance.

  本文描述了各种炔烃的电化学镍催化加氢芳基化反应。在该反应中，通过电化学Ni催化，炔烃与芳基碘化物偶联，得到高选择性的反式烯烃。该方案的突出特点包括反应条件温和、操作简单、官能团耐受性优异。
• Silver-Mediated Selective Oxidative Cross-Coupling between C–H/P–H: A Strategy to Construct Alkynyl(diaryl)phosphine Oxide
  作者：Tao Wang、Songtao Chen、Ailong Shao、Meng Gao、Yangfei Huang、Aiwen Lei

  DOI：10.1021/ol503341t

  日期：2015.1.2

  A direct oxidative cross-coupling between terminal alkynes and secondary phosphine oxides was developed. This approach provides an efficient way to construct alkynyl di(phenyl) phosphine oxides from basic materials, and in this process, the silver salts act as a key promoter.
• O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE IN CROP PROTECTION COMPOSITIONS
  申请人：Novartis AG

  公开号：EP0848701A1

  公开（公告）日：1998-06-24
• MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US20170312363A1

  公开（公告）日：2017-11-02

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n 1 , n 2 , n 3 , and n 4 respectively are the degrees of polymerization of the branch chains, U 1 and U 2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F 1 and F 2 contain a functional group or a protected form R 01 thereof and may or may not contain a branched group G, correspondingly, the number of R 01 is one or more, F 1 and F 2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.
• US6319925B1
  申请人：——

  公开号：US6319925B1

  公开（公告）日：2001-11-20