6,6-dimethyl-4-p-tolyl-9-(3,4,5-trimethoxyphenyl)-5,6,7,9-tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione | 1357790-90-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6,6-dimethyl-4-p-tolyl-9-(3,4,5-trimethoxyphenyl)-5,6,7,9-tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione
• 英文别名: 6,6-Dimethyl-4-(4-methylphenyl)-9-(3,4,5-trimethoxyphenyl)-3,5,7,9-tetrahydrofuro[3,4-b]quinoline-1,8-dione
• CAS: 1357790-90-9
• 化学式: C₂₉H₃₁NO₆
• 分子量: 489.568
• InChiKey: DBHOWQSSJXCOSC-UHFFFAOYSA-N

物化性质

• 沸点：
  660.7±55.0 °C(predicted)
• 密度：
  1.28±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  74.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-羟乙酰乙酸内酯 、 5,5-二甲基-3-(4-甲基苯胺基)环己-2-烯-1-酮 、 3,4,5-三甲氧基苯甲醛 在 L-脯氨酸 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以91%的产率得到6,6-dimethyl-4-p-tolyl-9-(3,4,5-trimethoxyphenyl)-5,6,7,9-tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione
  参考文献：
  名称：

  An efficient one-pot three-component synthesis of tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione derivatives catalyzed by L-proline

  摘要：

  AbstractL‐Proline is found to be an efficient catalyst for the synthesis of tetrahydrofuro[3,4‐b]quinoline‐1,8(3H,4H)‐dione derivatives. This protocol is novel and has the advantages of mild condition, high yield, and easy operation. J. Heterocyclic Chem., (2012).

  DOI：

  10.1002/jhet.782

文献信息

• An efficient one-pot three-component synthesis of tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione derivatives catalyzed by L-proline
  作者：Chun-Ling Shi、Hui Chen、Daqing Shi

  DOI：10.1002/jhet.782

  日期：2012.1

  AbstractL‐Proline is found to be an efficient catalyst for the synthesis of tetrahydrofuro[3,4‐b]quinoline‐1,8(3H,4H)‐dione derivatives. This protocol is novel and has the advantages of mild condition, high yield, and easy operation. J. Heterocyclic Chem., (2012).