(±)-5-(piperidin-2-yl)pyridin-2-amine | 100133-12-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: (±)-5-(piperidin-2-yl)pyridin-2-amine
• 英文别名: 1,2,3,4,5,6-hexahydro-[2,3']bipyridyl-6'-ylamine；5-(Piperidin-2-yl)pyridin-2-amine；5-piperidin-2-ylpyridin-2-amine
• CAS: 100133-12-8
• 化学式: C₁₀H₁₅N₃
• mdl: MFCD18661346
• 分子量: 177.249
• InChiKey: OHVVRGHVPGLLTQ-UHFFFAOYSA-N

物化性质

• 沸点：
  340.4±42.0 °C(Predicted)
• 密度：
  1.092±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (±)-5-(piperidin-2-yl)pyridin-2-amine 以 四氢呋喃 、 乙腈 为溶剂， 反应 38.0h， 生成
  参考文献：
  名称：

  Natural products as templates for bioactive compound libraries. 3*. novel heterocycles and peptidomimetics generated from anabasine by isocyanide-based multicomponent reactions

  摘要：

  Anabasine served as a starting material for the synthesis of two series of novel, drug-like compounds. On the one hand, anabasine was subjected to a direct Chichibabin amination and elaborated into medicinally relevant, racemic 6-(piperidin-2-yl)imidazo[1,2-a]pyridines via the Groebke-Blackburn reaction. On the other hand, anabasine was used as an amine for the Ugi reaction to provide novel non-racemic anabasine-containing 2-[(2-pyridin-3-yl)piperidin-1-yl]acetamide peptidomimetics with high diastereoselectivity.

  DOI：

  10.1007/s10593-012-1033-z
• 作为产物：
  描述：

  新烟碱 在 sodium amide 、 N,N-二甲基苯胺 、 羽扇豆宁 作用下， 生成 (±)-5-(piperidin-2-yl)pyridin-2-amine
  参考文献：
  名称：

  Relationship Between Physiological Loss, Performance Decrement, and Age in Master Athletes

  摘要：

  Background. The use of master athletes to describe an idealized rate of physiological loss associated with aging is quite common. The results of such studies suggest that older athletes may be able to reduce the rate of decline in functional loss. The findings of such studies have been questioned due to their limited sample size and the age range and gender of their subjects.Methods. We examined a group of 146 male and 82 female master athletes over the age of 40 years. Physiological parameters included maximal oxygen uptake ((V) over dot O(2)max), body composition, muscle strength, bone density, and blood chemistries Medical histories and training records were obtained via questionnaire.Results. Results demonstrated gender differences in body composition, blood chemistries, blood pressure, (V) over dot O(2)max, muscle strength, bone density, and performance (p < .05) All metabolic parameters for men and most for women demonstrated significant losses across the age range (p < .05). In addition, strength and performance for men and women and bone density for women declined significantly with age (p < .05). The demonstrated loss rates did not differ by gender.Conclusions. Although limited by the lack of a sedentary comparison group, these data suggest that age-related losses in (V) over dot O(2)max may not be different from data previously reported for older sedentary adults and that loss in muscle strength and performance with aging is not linear.

  DOI：

  10.1093/gerona/56.10.m618

文献信息

• Kaznel'son; Kabatschnik, Zhurnal Obshchei Khimii, 1934, vol. 4, p. 552,554
  作者：Kaznel'son、Kabatschnik

  DOI：——

  日期：——
• Katznelson; Kabatschnik, Chemische Berichte, 1935, vol. 68, p. 1247,1250
  作者：Katznelson、Kabatschnik

  DOI：——

  日期：——
• Natural products as templates for bioactive compound libraries. 3*. novel heterocycles and peptidomimetics generated from anabasine by isocyanide-based multicomponent reactions
  作者：Y. Sandulenko、M. Krasavin

  DOI：10.1007/s10593-012-1033-z

  日期：2012.7

  Anabasine served as a starting material for the synthesis of two series of novel, drug-like compounds. On the one hand, anabasine was subjected to a direct Chichibabin amination and elaborated into medicinally relevant, racemic 6-(piperidin-2-yl)imidazo[1,2-a]pyridines via the Groebke-Blackburn reaction. On the other hand, anabasine was used as an amine for the Ugi reaction to provide novel non-racemic anabasine-containing 2-[(2-pyridin-3-yl)piperidin-1-yl]acetamide peptidomimetics with high diastereoselectivity.
• Relationship Between Physiological Loss, Performance Decrement, and Age in Master Athletes
  作者：R. A. Wiswell、S. A. Hawkins、S. V. Jaque、D. Hyslop、N. Constantino、K. Tarpenning、T. Marcell、E. T. Schroeder

  DOI：10.1093/gerona/56.10.m618

  日期：2001.10.1

  Background. The use of master athletes to describe an idealized rate of physiological loss associated with aging is quite common. The results of such studies suggest that older athletes may be able to reduce the rate of decline in functional loss. The findings of such studies have been questioned due to their limited sample size and the age range and gender of their subjects.Methods. We examined a group of 146 male and 82 female master athletes over the age of 40 years. Physiological parameters included maximal oxygen uptake ((V) over dot O(2)max), body composition, muscle strength, bone density, and blood chemistries Medical histories and training records were obtained via questionnaire.Results. Results demonstrated gender differences in body composition, blood chemistries, blood pressure, (V) over dot O(2)max, muscle strength, bone density, and performance (p < .05) All metabolic parameters for men and most for women demonstrated significant losses across the age range (p < .05). In addition, strength and performance for men and women and bone density for women declined significantly with age (p < .05). The demonstrated loss rates did not differ by gender.Conclusions. Although limited by the lack of a sedentary comparison group, these data suggest that age-related losses in (V) over dot O(2)max may not be different from data previously reported for older sedentary adults and that loss in muscle strength and performance with aging is not linear.