2-(Quinolin-8-yloxy)-1-{4-[2-(quinolin-8-yloxy)acetyl]piperazin-1-YL}ethan-1-one | 892211-32-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(Quinolin-8-yloxy)-1-{4-[2-(quinolin-8-yloxy)acetyl]piperazin-1-YL}ethan-1-one
• 英文别名: 2-quinolin-8-yloxy-1-[4-(2-quinolin-8-yloxyacetyl)piperazin-1-yl]ethanone
• CAS: 892211-32-4
• 化学式: C₂₆H₂₄N₄O₄
• 分子量: 456.501
• InChiKey: KZWVJIDBFARZAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  84.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  mercury(II) perchlorate 、 2-(Quinolin-8-yloxy)-1-{4-[2-(quinolin-8-yloxy)acetyl]piperazin-1-YL}ethan-1-one 以 甲醇 、 氯仿 为溶剂， 生成
  参考文献：
  名称：

  A new quinoline-based chemosensor in ratiometric sensing of Hg²⁺ions

  摘要：

  A new quinoline-based chemosensor 1 has been designed and synthesised. Its metal ion-binding properties have been documented in organic and aqueous organic solvents. While chemosensor 1 recognises Hg2+ ions (K a=2.15x104M1) by exhibiting ratiometric change in emission in CHCl3/CH3OH (1:1, v/v), under similar condition both Zn2+ and Cd2+ ions are sensed by significant non-ratiometric increase in emission with measurable red shift. In DMSO/H2O (5:95, v/v), the sensor 1 exhibits a greater selectivity towards Hg2+ ions (K a=9.20x103M1) over the other metal ions examined.

  DOI：

  10.1080/10610278.2012.733818
• 作为产物：
  描述：

  8-羟基喹啉 、 2-氯-1-[4-(2-氯乙酰基)哌嗪-1-基]-乙酮 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 8.0h， 生成 2-(Quinolin-8-yloxy)-1-{4-[2-(quinolin-8-yloxy)acetyl]piperazin-1-YL}ethan-1-one
  参考文献：
  名称：

  A new quinoline-based chemosensor in ratiometric sensing of Hg²⁺ions

  摘要：

  A new quinoline-based chemosensor 1 has been designed and synthesised. Its metal ion-binding properties have been documented in organic and aqueous organic solvents. While chemosensor 1 recognises Hg2+ ions (K a=2.15x104M1) by exhibiting ratiometric change in emission in CHCl3/CH3OH (1:1, v/v), under similar condition both Zn2+ and Cd2+ ions are sensed by significant non-ratiometric increase in emission with measurable red shift. In DMSO/H2O (5:95, v/v), the sensor 1 exhibits a greater selectivity towards Hg2+ ions (K a=9.20x103M1) over the other metal ions examined.

  DOI：

  10.1080/10610278.2012.733818

文献信息

• A new quinoline-based chemosensor in ratiometric sensing of Hg²⁺ions
  作者：Kumaresh Ghosh、Debojyoti Tarafdar

  DOI：10.1080/10610278.2012.733818

  日期：2013.3.1

  A new quinoline-based chemosensor 1 has been designed and synthesised. Its metal ion-binding properties have been documented in organic and aqueous organic solvents. While chemosensor 1 recognises Hg2+ ions (K a=2.15x104M1) by exhibiting ratiometric change in emission in CHCl3/CH3OH (1:1, v/v), under similar condition both Zn2+ and Cd2+ ions are sensed by significant non-ratiometric increase in emission with measurable red shift. In DMSO/H2O (5:95, v/v), the sensor 1 exhibits a greater selectivity towards Hg2+ ions (K a=9.20x103M1) over the other metal ions examined.