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(5-iodobenzofuran-2-yl)(4-nitrophenyl)methanone | 1320336-29-5

中文名称
——
中文别名
——
英文名称
(5-iodobenzofuran-2-yl)(4-nitrophenyl)methanone
英文别名
(5-Iodo-1-benzofuran-2-yl)-(4-nitrophenyl)methanone
(5-iodobenzofuran-2-yl)(4-nitrophenyl)methanone化学式
CAS
1320336-29-5
化学式
C15H8INO4
mdl
——
分子量
393.137
InChiKey
IOSXKAORTSESNE-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.5
  • 重原子数:
    21
  • 可旋转键数:
    2
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.0
  • 拓扑面积:
    76
  • 氢给体数:
    0
  • 氢受体数:
    4

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    (5-iodobenzofuran-2-yl)(4-nitrophenyl)methanone盐酸 、 tin(ll) chloride 、 sodium hydroxide 作用下, 以 乙醇 为溶剂, 反应 2.0h, 生成 (4-aminophenyl)(5-iodobenzofuran-2-yl)methanone
    参考文献:
    名称:
    Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for β-amyloid plaques
    摘要:
    A series of benzofuran-2-yl(phenyl)methanone derivatives were synthesized and evaluated as novel probes for beta-amyloid plaques. These derivatives were produced by a Rap-Stoermer condensation reaction. Compounds with a N,N-dimethylamino group displayed high affinity for A beta(1-42) aggregates with K(i) values in the nanomolar range. Autoradiography with brain sections of AD model mice (APP/PS1) revealed that a radioiodinated probe, [(125)I]10, labeled beta-amyloid plaques selectively and displayed good brain uptake (3.53% ID/g) at 2 min. The results suggest that benzofuran-2-yl(phenyl) methanone derivatives should be investigated further as potential probes for detecting beta-amyloid plaques in the AD brain. (C) 2011 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.bmc.2011.04.049
  • 作为产物:
    描述:
    5-碘水杨醛2-溴-4'-硝基苯乙酮potassium carbonate 作用下, 以 丙酮 为溶剂, 反应 8.0h, 以87%的产率得到(5-iodobenzofuran-2-yl)(4-nitrophenyl)methanone
    参考文献:
    名称:
    Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for β-amyloid plaques
    摘要:
    A series of benzofuran-2-yl(phenyl)methanone derivatives were synthesized and evaluated as novel probes for beta-amyloid plaques. These derivatives were produced by a Rap-Stoermer condensation reaction. Compounds with a N,N-dimethylamino group displayed high affinity for A beta(1-42) aggregates with K(i) values in the nanomolar range. Autoradiography with brain sections of AD model mice (APP/PS1) revealed that a radioiodinated probe, [(125)I]10, labeled beta-amyloid plaques selectively and displayed good brain uptake (3.53% ID/g) at 2 min. The results suggest that benzofuran-2-yl(phenyl) methanone derivatives should be investigated further as potential probes for detecting beta-amyloid plaques in the AD brain. (C) 2011 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.bmc.2011.04.049
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文献信息

  • Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for β-amyloid plaques
    作者:Mengchao Cui、Masahiro Ono、Hiroyuki Kimura、Boli Liu、Hideo Saji
    DOI:10.1016/j.bmc.2011.04.049
    日期:2011.7
    A series of benzofuran-2-yl(phenyl)methanone derivatives were synthesized and evaluated as novel probes for beta-amyloid plaques. These derivatives were produced by a Rap-Stoermer condensation reaction. Compounds with a N,N-dimethylamino group displayed high affinity for A beta(1-42) aggregates with K(i) values in the nanomolar range. Autoradiography with brain sections of AD model mice (APP/PS1) revealed that a radioiodinated probe, [(125)I]10, labeled beta-amyloid plaques selectively and displayed good brain uptake (3.53% ID/g) at 2 min. The results suggest that benzofuran-2-yl(phenyl) methanone derivatives should be investigated further as potential probes for detecting beta-amyloid plaques in the AD brain. (C) 2011 Elsevier Ltd. All rights reserved.
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