2-(furan-2-yl)-2-[4-(4-acetylphenoxymethyl)-1H-1,2,3-triazol-1-yl]ethanol | 1225219-28-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(furan-2-yl)-2-[4-(4-acetylphenoxymethyl)-1H-1,2,3-triazol-1-yl]ethanol
• 英文别名: 1-[4-[[1-[1-(Furan-2-yl)-2-hydroxyethyl]triazol-4-yl]methoxy]phenyl]ethanone
• CAS: 1225219-28-2
• 化学式: C₁₇H₁₇N₃O₄
• 分子量: 327.34
• InChiKey: OKHUYQXPFBZBPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  90.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-[4-(2-丙炔基氧基)苯基]-1-乙酮 、 D-葡萄烯糖 在 叠氮基三甲基硅烷 、 copper(II) bis(trifluoromethanesulfonate) 、 铜 作用下， 以 乙腈 为溶剂， 反应 7.83h， 以82%的产率得到2-(furan-2-yl)-2-[4-(4-acetylphenoxymethyl)-1H-1,2,3-triazol-1-yl]ethanol
  参考文献：
  名称：

  Multicomponent Cascade Transformation of d-Glucal to Furan-Appended Triazole Glycoconjugates

  摘要：

  Novel one-pot three- and four-component transformations of D-glucal to furan-based hydroxy triazole glycoconjugates have been achieved by sequential addition of reagents in the presence of Cu(OTf)(2)-Cu powder as catalysts. In general the carbohydrate-derived products were formed with high diastereomeric purity.

  DOI：

  10.1021/jo100475e

文献信息

• Multicomponent Cascade Transformation of <scp>d</scp>-Glucal to Furan-Appended Triazole Glycoconjugates
  作者：Syed Khalid Yousuf、Subhash Chandra Taneja、Debaraj Mukherjee

  DOI：10.1021/jo100475e

  日期：2010.5.7

  Novel one-pot three- and four-component transformations of D-glucal to furan-based hydroxy triazole glycoconjugates have been achieved by sequential addition of reagents in the presence of Cu(OTf)(2)-Cu powder as catalysts. In general the carbohydrate-derived products were formed with high diastereomeric purity.