Propyl-D-galactopyranosid | 118245-33-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Propyl-D-galactopyranosid
• 英文别名: (2R,3R,4S,5R)-2-(hydroxymethyl)-6-propoxyoxane-3,4,5-triol
• CAS: 118245-33-3
• 化学式: C₉H₁₈O₆
• 分子量: 222.238
• InChiKey: ITOWTHYPYGRTRL-MBOVONDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丙醇 、 4-硝基苯基-α-D-吡喃半乳糖苷 在 α-D-galactosidase from Trichoderma reesei 作用下， 以 水 为溶剂， 生成 Propyl-D-galactopyranosid
  参考文献：
  名称：

  Transglycosylation activity of α-d-galactosidase from Trichoderma reesei An investigation of the active site

  摘要：

  The transglycosylation reaction catalyzed by alpha-D-galactosidase from the mycelial fungus Trichoderma reesei was studied using p-nitrophenyl alpha-D-galactopyranoside (PNPG). An aliphatic alcohol or the substrate itself can be an acceptor of the galactose residue in this reaction. The transglycosylation products were identified as alkyl galactosides in the case of alcohols or as galactobioside and galactotrioside in the case of PNPG. The transglycosylation rates follow a first-order equation with respect to the alcohol concentrations except for methanol. Affinities of some substrates were estimated from their K-i values in the reaction of the enzyme with PNPG. Transglycosylation of the substrate suggests a model for the enzyme active center. It is proposed that the active center includes two galactose-binding sites and a hydrophobic site. (C) 1998 Elsevier Science Ltd.

  DOI：

  10.1016/s0008-6215(97)00229-2

文献信息

• SYNTHESIS OF MONOETHERS OF SUGAR COMPRISING A LONG ALKYL CHAIN AND USES THEREOF AS A SURFACTANT
  申请人：TEREOS STARCH & SWEETENERS BELGIUM

  公开号：US20180265533A1

  公开（公告）日：2018-09-20

  A process for obtaining a mixture of C4-C8 and C9-C18 alkyl monoether of saccharide, comprising: a) a first step of acetalization or trans-acetalization of a saccharide or of a mixture of saccharides with a C4-C8 aliphatic aldehyde or the acetal thereof, b) a second consecutive or simultaneous step of acetalization or trans-acetalization of the product obtained in a) of the saccharide or mixture of saccharides with a C9-C18 aliphatic aldehyde or the acetal thereof, c) a step of catalytic hydrogenolysis of the saccharide acetals obtained, and d) a step of recovery of a mixture of C4-C8 and C9-C18 alkyl saccharide monoethers. The invention further relates to a mixture of C4-C8 and C9-C18 alkyl saccharide monoethers and the use thereof as a surfactant.

  一种获取C4-C8和C9-C18糖苷烷基单醚混合物的方法，包括：a)对糖苷或糖苷混合物与C4-C8脂肪族醛或其缩醛进行缩醛化或转缩醛化的第一步骤，b)对步骤a)中得到的糖苷或糖苷混合物与C9-C18脂肪族醛或其缩醛进行连续或同时的缩醛化或转缩醛化的第二步骤，c)对所得糖苷缩醛进行催化氢解的步骤，以及d)回收C4-C8和C9-C18糖苷烷基单醚混合物的步骤。该发明还涉及一种C4-C8和C9-C18糖苷烷基单醚混合物及其作为表面活性剂的用途。
• ANTIBACTERIAL COMPOSITION CONTAINING AN ISOMER MIXTURE OF MONOSACCHARIDE ALKYL MONOACETALS OR MONOETHERS
  申请人：TEREOS STARCH & SWEETENERS BELGIUM

  公开号：US20170347653A1

  公开（公告）日：2017-12-07

  A bactericidal or bacteriostatic composition comprising an isomer mixture of monosaccharide alkyl monoethers or monoacetals, its use in the treatment or prevention of Gram-positive bacterial infections, its use as a hygiene or dermatological product for external use and a method for disinfecting surfaces.

  一种杀菌或抑菌组合物，包括单糖烷基单醚或单缩醛的异构体混合物，其用于治疗或预防革兰氏阳性细菌感染，其用作外用卫生或皮肤学产品，以及一种消毒表面的方法。
• Synthesis of monoethers of sugar comprising a long alkyl chain and uses thereof as a surfactant
  申请人：TEREOS STARCH & SWEETENERS BELGIUM

  公开号：US10442830B2

  公开（公告）日：2019-10-15

  A process for obtaining a mixture of C4-C8 and C9-C18 alkyl monoether of saccharide, comprising: a) a first step of acetalization or trans-acetalization of a saccharide or of a mixture of saccharides with a C4-C8 aliphatic aldehyde or the acetal thereof, b) a second consecutive or simultaneous step of acetalization or trans-acetalization of the product obtained in a) of the saccharide or mixture of saccharides with a C9-C18 aliphatic aldehyde or the acetal thereof, c) a step of catalytic hydrogenolysis of the saccharide acetals obtained, and d) a step of recovery of a mixture of C4-C8 and C9-C18 alkyl saccharide monoethers. The invention further relates to a mixture of C4-C8 and C9-C18 alkyl saccharide monoethers and the use thereof as a surfactant.

  一种获得 C4-C8 和 C9-C18 烷基单醚糖混合物的工艺，包括a) 第一步将糖或糖混合物与 C4-C8 脂肪族醛或其缩醛进行缩醛化或反缩醛化； b) 第二步连续或同时将 a) 中得到的糖或糖混合物产物与 C9-C18 脂肪族醛或其缩醛进行缩醛化或反缩醛化、c) 对得到的糖醛进行催化氢解，以及 d) 回收 C4-C8 和 C9-C18 烷基糖单乙醚混合物。本发明还涉及一种 C4-C8 和 C9-C18 烷基糖单醚混合物及其作为表面活性剂的用途。
• Antibacterial composition containing an isomer mixture of monosaccharide alkyl monoacetals or monoethers
  申请人：TEREOS STARCH & SWEETENERS BELGIUM

  公开号：US10537103B2

  公开（公告）日：2020-01-21

  A bactericidal or bacteriostatic composition comprising an isomer mixture of monosaccharide alkyl monoethers or monoacetals, its use in the treatment or prevention of Gram-positive bacterial infections, its use as a hygiene or dermatological product for external use and a method for disinfecting surfaces.

  一种由单糖烷基单醚或单乙醛异构体混合物组成的杀菌或抑菌组合物，其用途包括治疗或预防革兰氏阳性细菌感染，用作外用卫生或皮肤产品，以及一种表面消毒方法。
• Systems and methods for cell preservation
  申请人：Toner Mehmet

  公开号：US20050277107A1

  公开（公告）日：2005-12-15

  The present invention generally relates to devices and methods for the preservation of cells using drying, freezing, and other related techniques. In one set of embodiments, the invention allows for the preservation of cells in a dried state. In another set of embodiments, the invention allows for the preservation of cells within a glass or other non-viscous, non-frozen media. In some embodiments, the invention allows for the preservation of cells at temperatures below the freezing point of water, and in some cases at cryogenic temperatures, without inducing ice formation. The cells, in certain embodiments, may be preserved in the presence of intracellular and/or extracellular carbohydrates (which may be the same or different), for example, trehalose and sucrose. Carbohydrates may be transported intracellularly by any suitable technique, for example, using microinjection, or through non-microinjected methods such as through pore-forming proteins, electroporation, heat shock, etc. In certain instances, the glass transition temperature of the cells may be raised, e.g., by transporting a carbohydrate intracellularly. In some cases, the cells may be dried and/or stored, for example, in a substantially moisture-saturated environment or a desiccating environment. The cells may also be stored in a vacuum or a partial vacuum. The cells may be protected from oxygen, moisture, and/or light during storage. In certain cases, an inhibitor, such as a cell death inhibitor, a protease inhibitor, an apoptosis inhibitor, and/or an oxidative stress inhibitor may be used during preservation of the cells. The cells may be stored for any length of time, then recovered to a viable state, e.g., through rehydration, for further use.

  本发明一般涉及利用干燥、冷冻和其他相关技术保存细胞的装置和方法。在一组实施方案中，本发明可以在干燥状态下保存细胞。在另一组实施方案中，本发明可将细胞保存在玻璃或其他非粘性、非冷冻介质中。在某些实施例中，本发明可在低于水的冰点温度下保存细胞，在某些情况下还可在低温下保存细胞，而不会导致冰的形成。在某些实施方案中，细胞可在细胞内和/或细胞外碳水化合物（可相同或不同）的存在下保存，例如，三卤糖和蔗糖。碳水化合物可通过任何合适的技术在细胞内运输，例如使用微量注射，或通过非微量注射方法，如通过孔形成蛋白、电穿孔、热休克等。在某些情况下，可通过在细胞内输送碳水化合物等方法提高细胞的玻璃转化温度。在某些情况下，可将细胞干燥和/或储存，例如，储存在水分基本饱和的环境或干燥环境中。细胞也可以储存在真空或部分真空环境中。在储存过程中，可防止细胞受到氧气、湿气和/或光线的影响。在某些情况下，细胞保存期间可使用抑制剂，如细胞死亡抑制剂、蛋白酶抑制剂、细胞凋亡抑制剂和/或氧化应激抑制剂。细胞可储存任意时间，然后通过复水等方式恢复到可存活状态，以供进一步使用。