2-溴-2-羟基-1-苯乙酮 | 76462-89-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-溴-2-羟基-1-苯乙酮
• 英文名称: 2-Bromo-2-hydroxy-1-phenylethan-1-one
• 英文别名: 2-bromo-2-hydroxy-1-phenylethanone
• CAS: 76462-89-0
• 化学式: C₈H₇BrO₂
• 分子量: 215.04
• InChiKey: VPKKKVKUOKACNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-溴-2-羟基-1-苯乙酮 、 甲氧基胺盐酸盐 、 甲醇 在 甲醇 、 乙酸乙酯 、 Sodium sulfate-III 、 petroleum ether 作用下， 反应 4.0h， 以affording 74 g (52% of theory) of crystalline 2-bromo-1-(2-hydroxy-phenyl)-ethanone O-methyl-oxime的产率得到2-bromo-1-(2-hydroxy-phenyl)-ethanone O-methyl-oxime
  参考文献：
  名称：

  Process for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl) dioxazines

  摘要：

  本发明涉及一种新型制备3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷的方法，该化合物为制备具有杀菌性质化合物的中间体（WO 95-04728）。此外，本发明还涉及新型3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷、其制备的新型中间体以及制备新型中间体的多种方法。

  公开号：

  US06005104A1

文献信息

• [EN] PROCESS FOR PREPARATION OF (DL) -NOREPINEPHRINE ACID ADDITION SALT, A KEY INTERMEDIATE OF (R) - (-) - NOREPINEPHRINE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN SEL D'ADDITION D'ACIDE DE NORÉPINÉPHRINE (DL), INTERMÉDIAIRE CLÉ DE LA NORÉPINÉPHRINE (R) - (-) -
  申请人：NEON LAB LTD

  公开号：WO2013008247A1

  公开（公告）日：2013-01-17

  The invention discloses a process for preparation of (dl)-norepinephrine salt by reacting 3,4-dihydroxy-a-haloacetophenone with hexamethylenetetramine to provide hexamine salt; followed by hydrolysis and hydrogenation. The invention also discloses a novel intermediate formed in the process and its synthesis.

  该发明揭示了一种制备(dl)-去甲肾上腺素盐的方法，通过将3,4-二羟基-α-卤代乙酰苯酮与六亚甲基四胺反应以提供六胺盐；随后进行水解和氢化。该发明还揭示了该过程中形成的一种新型中间体及其合成方法。
• Anti-glycation agents for preventing age- diabetes- and smoking-related complications
  申请人：Yeboah Faustinus

  公开号：US20050043408A1

  公开（公告）日：2005-02-24

  The invention provides new inhibitors of protein glycation, identified from compound libraries by a high throughput screening assay. The anti-glycation agents so identified are characterized by a variety of chemical structures and are useful for the prevention or treatment of age-, diabetes-, and smoking-related complications, including neuropathy, nephropathy, ocular pathologies, or the loss of mechanical properties of collagenous tissues. Among compounds identified as having the anti-glycation activity, of special interest are epinephrine and its analogs, in particular D-epinephrine and its analogs, which are particularly useful for the prevention or treatment of age-, diabetes-, and smoking-related ocular pathologies.

  这项发明提供了新的蛋白质糖基化抑制剂，通过高通量筛选检测从化合物库中鉴定出来。所鉴定的抗糖基化剂具有多种化学结构，可用于预防或治疗与年龄、糖尿病和吸烟有关的并发症，包括神经病变、肾病、眼部病理或胶原组织的机械性能丧失。在被鉴定为具有抗糖基化活性的化合物中，特别感兴趣的是肾上腺素及其类似物，特别是D-肾上腺素及其类似物，可用于预防或治疗与年龄、糖尿病和吸烟有关的眼部病理。
• Process for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl) dioxazines
  申请人：Bayer Aktiengesellschaft

  公开号：US06005104A1

  公开（公告）日：1999-12-21

  The present invention relates to a novel process for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines which are known as intermediates for preparing compounds having fungicidal properties (WO 95-04728). Furthermore, the invention relates to novel 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines, to novel intermediates for their preparation and to a plurality of processes for preparing the novel intermediates.

  本发明涉及一种新型制备3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷的方法，该化合物为制备具有杀菌性质化合物的中间体（WO 95-04728）。此外，本发明还涉及新型3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷、其制备的新型中间体以及制备新型中间体的多种方法。
• Process for preparing 3-(1-hydroxphenyl-1-alkoximinomethyl)dioxazines
  申请人：Bayer Aktiengesellschaft

  公开号：US06335454B1

  公开（公告）日：2002-01-01

  The present invention relates to a novel process for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines which are known as intermediates for preparing compounds having fungicidal properties (WO 95-04728). Furthermore, the invention relates to novel 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines, to novel intermediates for their preparation and to a plurality of processes for preparing the novel intermediates.

  本发明涉及一种制备3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷的新工艺，该物质是制备具有杀真菌性质的化合物的中间体（WO 95-04728）。此外，本发明还涉及新的3-(1-羟基苯基-1-烷氧基亚甲基)二氧杂环己烷，以及制备它们的新中间体和多种制备新中间体的工艺。
• ANTI-GLYCATION AGENTS FOR PREVENTING AGE-, DIABETES-, AND SMOKING-RELATED COMPLICATIONS
  申请人：YEBOAH Faustinus

  公开号：US20080139664A1

  公开（公告）日：2008-06-12

  The invention provides new inhibitors of protein glycation, identified from compound libraries by a high throughput screening assay. The anti-glycation agents so identified are characterized by a variety of chemical structures and are useful for the prevention or treatment of age-, diabetes-, and smoking-related complications, including neuropathy, nephropathy, ocular pathologies, or the loss of mechanical properties of collagenous tissues. Among compounds identified as having the anti-glycation activity, of special interest are epinephrine and its analogs, in particular D-epinephrine and its analogs, which are particularly useful for the prevention or treatment of age-, diabetes-, and smoking-related ocular pathologies.

  该发明提供了新的蛋白质糖基化抑制剂，通过高通量筛选检测从化合物库中确定。所确定的抗糖基化剂具有各种化学结构，并可用于预防或治疗与年龄、糖尿病和吸烟相关的并发症，包括神经病变、肾病、眼部病理或胶原组织机械性能的丧失。在被确定为具有抗糖基化活性的化合物中，特别感兴趣的是肾上腺素及其类似物，特别是D-肾上腺素及其类似物，这些物质特别适用于预防或治疗与年龄、糖尿病和吸烟相关的眼部病理。