1,13-diphenyl-1,4,7,10,13-pentaoxatridecane | 20768-77-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,13-diphenyl-1,4,7,10,13-pentaoxatridecane
• 英文别名: bis<2-(2-phenoxy)ethyl>ether；1,13-Diphenyl-1,4,7,10,13-pentaoxatridecan；1,11-Bis-(phenyloxy)-3,6,9-trioxoundecan；1,11-Diphenoxy-3,6,9-trioxa-undecan；Tetraethylene glycol diphenyl ether；2-[2-[2-(2-phenoxyethoxy)ethoxy]ethoxy]ethoxybenzene
• CAS: 20768-77-8
• 化学式: C₂₀H₂₆O₅
• 分子量: 346.423
• InChiKey: PMOSUUISWPPIPO-UHFFFAOYSA-N

物化性质

• 沸点：
  463.4±40.0 °C(Predicted)
• 密度：
  1.094±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,13-diphenyl-1,4,7,10,13-pentaoxatridecane 在 palladium on activated charcoal 氢气 、 硝酸 、 乙酸酐 作用下， 生成 2-[2-[2-[2-(2-苯氧基乙氧基)乙氧基]乙氧基]乙氧基]苯胺
  参考文献：
  名称：

  Phase-transfer-catalyzed Gomberg-Bachmann synthesis of unsymmetrical biarenes: a survey of catalysts and substrates

  摘要：

  DOI：

  10.1021/jo00183a021
• 作为产物：
  描述：

  三缩四乙二醇 在 吡啶 、 三溴化磷 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 79.0h， 生成 1,13-diphenyl-1,4,7,10,13-pentaoxatridecane
  参考文献：
  名称：

  ¹H NMR Studies on the Interactions of Acyclic Polyethers with Dimethyltin Bichloride in Aromatic Solvents

  摘要：

  通过 1H NMR 光谱法研究了各种无环聚醚、RO(CH2CH2O)nR′(R, R′=CH3, Ph)和二甲基二氯化锡（DMTC）在芳香溶剂中的相互作用。根据连续变化的方法，揭示了在苯中乙二胺、CH3O(CH2CH2O)nCH3（n=2、3、4）和 DMTC 之间形成的 1 : 1 复合物。2J(119Sn-CH3) 值表明这些配合物具有扭曲的反八面体构型。从稳定性常数的统计考虑发现，这些配合物中的配位实际上是通过相邻的两个氧原子进行的。在苯中，DMTC 与乙二胺（n=5、6）以及在甲苯和 1-氯萘中与此处使用的所有乙二胺配位，生成了 1 : 1 和 1 : 2 乙二胺/DMTC 配比的络合物。在 PhO(CH2CH2O)nCH3（n=3、4、5）中也出现了 1 : 1 和 1 : 2 的共存现象，而在 PhO(CH2CH2O)nPh（n=2、3、4）和 DMTC 之间没有观察到明显的相互作用。根据这些观察结果，我们推测 1 : 2 复合物的额外形成是由聚醚的体积造成的。

  DOI：

  10.1246/bcsj.54.2964

文献信息

• HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS
  申请人：Bezwada Rao S.

  公开号：US20090082540A1

  公开（公告）日：2009-03-26

  The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates.

  本发明涉及一种新型线性和多臂可水解连接剂和交联剂的发现，用于合成可生物降解聚合物，如聚酯、聚氨酯、聚酰胺、聚脲和可降解环氧胺树脂。本发明的线性和多臂可水解连接剂包括对称和/或非对称的醚羧酸、胺、酰胺二醇、胺多元醇和异氰酸。
• Process for the preparation of cyclic esters and method for purification of the same
  申请人：——

  公开号：US20030191326A1

  公开（公告）日：2003-10-09

  The present invention provides a process for production of a cyclic ester by depolymerization of an aliphatic polyester. In the process, a mixture containing the aliphatic polyester and a specific polyalkylene glycol ether, which has a boiling point of 230-450° C. and a molecular weight of 150-450, is heated under normal or reduced pressure to a temperature at which depolymerization of the aliphatic polyester takes place. Then, a substantially homogeneous solution phase, consisting of the melt phase of the aliphatic polyester and the liquid phase of the polyalkylene glycol ether, is formed. Heating of the solution phase is continued to form the cyclic ester by depolymerization and distil out the cyclic ester together with the polyalkylene glycol ether, and then the cyclic ester is recovered from the distillate. The present invention also provides a process for purification of a crude cyclic ester by use of the specific polyalkylene glycol ether described above.

  本发明提供了一种通过脂肪族聚酯的降解来生产环酯的方法。在该过程中，将含有脂肪族聚酯和具有沸点在230-450°C和分子量在150-450之间的特定聚烷基乙二醇醚的混合物，在常压或减压下加热至脂肪族聚酯发生降解的温度。然后，形成由脂肪族聚酯的熔融相和聚烷基乙二醇醚的液相组成的基本均相溶液相。继续加热溶液相以通过降解形成环酯并与聚烷基乙二醇醚一起蒸馏出环酯，然后从馏出物中回收环酯。本发明还提供了一种利用上述特定聚烷基乙二醇醚对粗环酯进行纯化的方法。
• FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE
  申请人：Bezwada Rao S.

  公开号：US20090105352A1

  公开（公告）日：2009-04-23

  This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.

  这项发明涉及发现的功能化三氯生单体和寡聚体，当它们被纳入医疗设备的基质中，或作为涂层的一部分应用于医疗设备和/或消费品时，可以延长医疗设备和/或消费品的抗菌性能持续时间。
• ¹H NMR Studies on the Interactions of Acyclic Polyethers with Dimethyltin Bichloride in Aromatic Solvents
  作者：Junzo Otera、Tadashi Shiomi、Kazuhiko Murakami、Yoshikane Kawasaki

  DOI：10.1246/bcsj.54.2964

  日期：1981.10

  The interactions between various acyclic polyethers, RO(CH2CH2O)nR′(R, R′=CH3, Ph), and dimethyltin dichloride (DMTC) in aromatic solvents have been studied by means of 1H NMR spectroscopy. On the basis of a continuous variation method, the formation of the 1 : 1 complexes between glymes, CH3O(CH2CH2O)nCH3(n=2, 3, 4), and DMTC was revealed in benzene. The 2J(119Sn–CH3) values suggested distorted trans-octahedral configurations for these complexes. From the statistical consideration of stability constants, it was found that the coordination occurred virtually through neighboring two oxygen atoms in these complexes. DMTC gave the complexes of both 1 : 1 and 1 : 2 glyme/DMTC stoichiometry with glymes (n=5, 6) in benzene and with all glymes employed here in toluene and 1-chloronaphthalene. Coexistence of 1 : 1 and 1 : 2 species was also encountered for PhO(CH2CH2O)nCH3 (n=3, 4, 5), whereas no appreciable interaction was observed between PhO(CH2CH2O)nPh (n=2, 3, 4) and DMTC. On the basis of these observations, the additional formation of the 1 : 2 complexes was assumed to be caused by the bulkiness of polyethers.

  通过 1H NMR 光谱法研究了各种无环聚醚、RO(CH2CH2O)nR′(R, R′=CH3, Ph)和二甲基二氯化锡（DMTC）在芳香溶剂中的相互作用。根据连续变化的方法，揭示了在苯中乙二胺、CH3O(CH2CH2O)nCH3（n=2、3、4）和 DMTC 之间形成的 1 : 1 复合物。2J(119Sn-CH3) 值表明这些配合物具有扭曲的反八面体构型。从稳定性常数的统计考虑发现，这些配合物中的配位实际上是通过相邻的两个氧原子进行的。在苯中，DMTC 与乙二胺（n=5、6）以及在甲苯和 1-氯萘中与此处使用的所有乙二胺配位，生成了 1 : 1 和 1 : 2 乙二胺/DMTC 配比的络合物。在 PhO(CH2CH2O)nCH3（n=3、4、5）中也出现了 1 : 1 和 1 : 2 的共存现象，而在 PhO(CH2CH2O)nPh（n=2、3、4）和 DMTC 之间没有观察到明显的相互作用。根据这些观察结果，我们推测 1 : 2 复合物的额外形成是由聚醚的体积造成的。
• METHOD FOR PRODUCING a-HYDROXYCARBOXYLIC ACID DIMERIC CYCLIC ESTER
  申请人：Kureha Corporation

  公开号：US20190330175A1

  公开（公告）日：2019-10-31

  Provided is a method for producing a high purity α-hydroxycarboxylic acid dimeric cyclic ester while heavy-component formation from an α-hydroxycarboxylic acid oligomer is suppressed. An α-hydroxycarboxylic acid dimeric cyclic ester is obtained by performing a depolymerization reaction in the coexistence of an inorganic acid or an inorganic acid salt or a mixture thereof; and an organophosphorus compound.

  提供了一种制备高纯度α-羟基羧酸二聚环酯的方法，同时抑制从α-羟基羧酸寡聚体中形成重组分。通过在无机酸或无机酸盐或二者混合物的共存下进行解聚反应，并加入有机磷化合物，可以得到α-羟基羧酸二聚环酯。