2-溴-3-氨基-4-甲基吡啶 | 126325-50-6

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-溴-3-氨基-4-甲基吡啶
• 中文别名: 3-氨基-2-溴-4-甲基吡啶；4-甲基-3-氨基-2-溴吡啶
• 英文名称: 2-bromo-4-methylpyridin-3-amine
• 英文别名: 3-amino-2-bromo-4-picoline；2-bromo-3-amino-4-methylpyridine
• CAS: 126325-50-6
• 化学式: C₆H₇BrN₂
• mdl: MFCD04112497
• 分子量: 187.039
• InChiKey: RQGNAHOAQQVKDE-UHFFFAOYSA-N

物化性质

• 沸点：
  308.0±37.0 °C(Predicted)
• 密度：
  1.593±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  室温

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3-Amino-2-bromo-4-picoline
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 3-Amino-2-bromo-4-picoline
CAS number: 126325-50-6

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C6H7BrN2
Molecular weight: 187

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-溴-3-氨基-4-甲基吡啶 在 potassium acetate 、 溶剂黄146 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 71.0h， 以29%的产率得到7-溴-1H-吡唑并[3,4-c]吡啶
  参考文献：
  名称：

  [EN] PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE
  [FR] COMPOSÉS À BASE DE 1,3-OXAZIN-2-AMINE FUSIONNÉE AVEC DU CYCLOPROPYLE PERFLUORÉ UTILISABLES EN TANT QU'INHIBITEURS DE LA BÊTA-SÉCRÉTASE ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  本发明提供了一类新的化合物，用于调节β-分泌酶（BACE）活性。这些化合物具有一般的化学式I：{在此插入结构} I，其中变量A4、A5、A6、A8，以及化学式I中的每个Ra、Rb、R1、R2、R3和R7，在本文中分别定义。该发明还提供了包含这些化合物的药物组合物，以及用于治疗与A-beta斑块形成和沉积相关的疾病和/或症状的化合物和组合物的用途，这些疾病和症状是由BACE的生物活性引起的。这种由BACE介导的疾病包括阿尔茨海默病、认知缺陷、认知障碍、精神分裂症和其他中枢神经系统疾病。该发明还提供了化学式II和III的化合物，以及其亚式化合物、中间体和制备本发明化合物的方法。

  公开号：

  WO2014138484A1
• 作为产物：
  描述：

  2-bromo-4-methylnicotinamide 在 sodium hypochlorite 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 4.0h， 以90%的产率得到2-溴-3-氨基-4-甲基吡啶
  参考文献：
  名称：

  一种2-异丙基-3-氨基-4-甲基吡啶的合成方法

  摘要：

  本发明公开了一种2‑异丙基‑3‑氨基‑4‑甲基吡啶的制备方法，所述制备方法的具体步骤为：(1)3‑氰基‑4‑甲基‑2‑吡啶酮与三溴氧磷反应，得到2‑溴代‑3‑氰基‑4‑甲基吡啶；(2)2‑溴代‑3‑氰基‑4‑甲基吡啶用浓硫酸水解，得到2‑溴‑4‑甲基烟酰胺；(3)2‑溴‑4‑甲基烟酰胺与次氯酸钠溶液在氢氧化钠条件下反应，发生霍夫曼重排，得到2‑溴‑3‑氨基‑4‑甲基吡啶；(4)2‑溴‑3‑氨基‑4‑甲基吡啶在含铁或镍的催化剂作用下，与异丙基格式试剂反应，得到2‑异丙基‑3‑氨基‑4‑甲基吡啶。本发明成本低廉，操作简单，是合成2‑异丙基‑3‑氨基‑4‑甲基吡啶的新方法。

  公开号：

  CN113354578A

文献信息

• QUINAZOLINONES AS PARP14 INHIBITORS
  申请人：Ribon Therapeutics Inc.

  公开号：US20190194174A1

  公开（公告）日：2019-06-27

  The present invention relates to quinazolinones and related compounds which are inhibitors of PARP14 and are useful, for example, in the treatment of cancer and inflammatory diseases.

  本发明涉及喹唑啉酮和相关化合物，它们是PARP14的抑制剂，例如在癌症和炎症性疾病的治疗中是有用的。
• PROCESS OF MAKING SOMATOSTATIN MODULATORS
  申请人：Crinetics Pharmaceuticals, Inc.

  公开号：US20190218202A1

  公开（公告）日：2019-07-18

  Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

  本文描述了一些肽类抑制素调节剂化合物，制备这类化合物的方法，包含这类化合物的药物组合物和药物，以及利用这类化合物治疗需要调节肽类抑制素活性的疾病、症状或疾病的方法。
• ENANTIOMERICALLY ENRICHED ARYLOAZOL-2-YL CYANOETHYLAMINO COMPOUNDS, METHOD OF MAKING AND METHOD OF USING THEREOF
  申请人：Soll Mark David

  公开号：US20100125089A1

  公开（公告）日：2010-05-20

  The present invention relates to novel aryloazol-2-yl-cyanoethylamino derivatives substantially enriched in an enantiomer of formula (I): and compounds of formula (IH) wherein R 3 , R 4 , R 5 , R 6 , R 7 , R 13a , R 13b , R 14a , R 14b , P, Q, V, W, X, Y, Z and a are as defined in the description, compositions thereof, processes for their preparation and their uses as pesticides.

  本发明涉及一种在式(I)的对映体方面显著富集的新颖芳基唑-2-基-氰基乙基氨基衍生物： 以及式(IH)的化合物 其中R3、R4、R5、R6、R7、R13a、R13b、R14a、R14b、P、Q、V、W、X、Y、Z和a如描述中所定义，以及它们的组合物、其制备方法以及它们作为杀虫剂的用途。
• [EN] DIHYDROOROTATE DEHYDROGENASE INHIBITORS<br/>[FR] INHIBITEURS DE DIHYDROOROTATE DÉSHYDROGÉNASE
  申请人：JANSSEN BIOTECH INC

  公开号：WO2020144638A1

  公开（公告）日：2020-07-16

  Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1a, R1b, R2, and R3, are defined herein.

  揭示了一种通过调节DHODH来治疗受影响的疾病、疾病或医疗状况的化合物、组合物和方法。这些化合物由以下式（I）表示：其中R1a、R1b、R2和R3在此处定义。
• 一种KRAS抑制剂化合物
  申请人：苏州信诺维医药科技有限公司

  公开号：CN111377918B

  公开（公告）日：2021-03-02

  本发明提供了一种具备式Ⅱ结构的化合物或其药学上可接受的盐、酯、异构体、溶剂化物、前药或同位素标记物：本发明提供的上述KRAS G12C抑制剂化合物对KRAS突变有较好的抑制作用，可以用于预防和/或治疗KRAS G12C介导的疾病。