2-溴-3-氨基-5-乙氧基吡啶 | 663193-84-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-溴-3-氨基-5-乙氧基吡啶
• 中文别名: 2-溴-5-乙氧基-3-氨基吡啶
• 英文名称: 2-Bromo-5-ethoxypyridin-3-amine
• CAS: 663193-84-8
• 化学式: C₇H₉BrN₂O
• 分子量: 217.06
• InChiKey: QMKWFTLJPPPHTB-UHFFFAOYSA-N

物化性质

• 沸点：
  346.5±37.0 °C(Predicted)
• 密度：
  1.532±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2933399090

文献信息

• CYCLIC AZAINDOLE-3-CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
  申请人：STEINHAGEN Henning

  公开号：US20110039861A1

  公开（公告）日：2011-02-17

  The present invention relates to cyclic azaindole-3-carboxamides of the formula I, wherein A, R, R 10 , R 20 , R 30 , R 40 , Y 1 , Y 2 , Y 3 , Y 4 , n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

  本发明涉及公式I的环状氮杂吲哚-3-羧酰胺，其中A、R、R10、R20、R30、R40、Y1、Y2、Y3、Y4、n、p和q具有所述要求中指示的含义，它们是有价值的药物活性化合物。具体来说，它们抑制酶肾素并调节肾素-血管紧张素系统的活性，可用于治疗高血压等疾病。此外，本发明还涉及制备公式I化合物的方法、它们的使用以及包含它们的药物组合物。
• US8580813B2
  申请人：——

  公开号：US8580813B2

  公开（公告）日：2013-11-12
• [EN] CYCLIC AZAINDOLE-3-CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS<br/>[FR] AZAINDOLE-3-CARBOXAMIDES CYCLIQUES, LEUR PRÉPARATION ET LEUR UTILISATION COMME PRODUITS PHARMACEUTIQUES
  申请人：SANOFI AVENTIS

  公开号：WO2009095162A1

  公开（公告）日：2009-08-06

  The present invention relates to cyclic azaindole-3-carboxamides of the formula (I) wherein A, R, R10, R20, R30, R40, Y1, Y2, Y3, Y4, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.