1-(Oct-2-YN-1-YL)cyclohexan-1-OL | 69754-61-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(Oct-2-YN-1-YL)cyclohexan-1-OL
• 英文别名: 1-oct-2-ynylcyclohexan-1-ol
• CAS: 69754-61-6
• 化学式: C₁₄H₂₄O
• 分子量: 208.344
• InChiKey: IXRVWFITBFTFJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  亚甲基环己烷氧化物 、 1-庚基锂 在 lithium perchlorate 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以81%的产率得到1-(Oct-2-YN-1-YL)cyclohexan-1-OL
  参考文献：
  名称：

  Stereo- and regioselective metal salt-catalyzed alkynylation of 1,2-epoxides

  摘要：

  A simple, efficient, stereoselective, and highly regioselective method for the synthesis of beta-hydroxyacetylenes by the direct opening of 1,2-epoxides with lithium acetylides in anhydrous THF, in the presence of metal salts, is described. This new method appears to be competitive and alternative to the other methods previously reported.

  DOI：

  10.1016/0040-4039(91)80237-z

文献信息

• Selective propargylation of carbonyl compounds with allenylstannane/alkyllithium mixed reagents
  作者：Masaaki Suzuki、Yasushi Morita、Ryoji Noyori

  DOI：10.1021/jo00289a013

  日期：1990.1
• Stereo- and regioselective metal salt-catalyzed alkynylation of 1,2-epoxides
  作者：Marco Chini、Paolo Crotti、Lucilla Favero、Franco Macchia

  DOI：10.1016/0040-4039(91)80237-z

  日期：1991.11

  A simple, efficient, stereoselective, and highly regioselective method for the synthesis of beta-hydroxyacetylenes by the direct opening of 1,2-epoxides with lithium acetylides in anhydrous THF, in the presence of metal salts, is described. This new method appears to be competitive and alternative to the other methods previously reported.