(S)-N-[(tert-butoxy)carbonyl]-γ-(uracil-1-yl)-β-homoalanine | 517877-31-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (S)-N-[(tert-butoxy)carbonyl]-γ-(uracil-1-yl)-β-homoalanine
• 英文别名: (S)-3-((tert-Butoxycarbonyl)amino)-4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid；(3S)-4-(2,4-dioxopyrimidin-1-yl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
• CAS: 517877-31-5
• 化学式: C₁₃H₁₉N₃O₆
• 分子量: 313.31
• InChiKey: XLLWNAAPHXNUTE-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (S)-N-[(tert-butoxy)carbonyl]-γ-(uracil-1-yl)-β-homoalanine 在 吡啶 、 4-二甲氨基吡啶 、 ammonium hydroxide 、 sodium hydroxide 、 水 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 33.0h， 生成 (S)-N-[(tert-butoxy)carbonyl]-γ-(cytosin-1-yl)-β-homoalanine
  参考文献：
  名称：

  Nucleo--Amino Acids: Synthesis and Oligomerization to -Homoalanyl-PNA

  摘要：

  The synthesis of thyminyl-, uracilyl-, cytosinyl-, and guaninyl-beta(3)-amino acids and the oligomerization of the cytosinyl- and guaninyl-beta(3)-amino acids to beta-homoalanyl-PNA are presented. The pyrimidinyl nucleobases were connected to the gamma-position of beta-homoalanine by Mitsunobu reaction with a beta-homoserine derivative or by nucleophilic substitution of methanesulfonates. For the preparation of the guaninyl-beta(3)-amino acid, a beta-lactam route was established that might be of interest also for the synthesis of other beta(3)-amino acid derivatives. The cytosinyl and guaninyl building blocks were oligomerized to hexamers. They form quite stable self-pairing complexes in H2O as indicated by temperature dependent UV and CD spectroscopy.

  DOI：

  10.1002/1522-2675(200211)85:11<3855::aid-hlca3855>3.0.co;2-a
• 作为产物：
  描述：

  benzyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoate 在 palladium on activated charcoal 氢气 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 溶剂黄146 为溶剂， 反应 96.0h， 生成 (S)-N-[(tert-butoxy)carbonyl]-γ-(uracil-1-yl)-β-homoalanine
  参考文献：
  名称：

  Nucleo--Amino Acids: Synthesis and Oligomerization to -Homoalanyl-PNA

  摘要：

  The synthesis of thyminyl-, uracilyl-, cytosinyl-, and guaninyl-beta(3)-amino acids and the oligomerization of the cytosinyl- and guaninyl-beta(3)-amino acids to beta-homoalanyl-PNA are presented. The pyrimidinyl nucleobases were connected to the gamma-position of beta-homoalanine by Mitsunobu reaction with a beta-homoserine derivative or by nucleophilic substitution of methanesulfonates. For the preparation of the guaninyl-beta(3)-amino acid, a beta-lactam route was established that might be of interest also for the synthesis of other beta(3)-amino acid derivatives. The cytosinyl and guaninyl building blocks were oligomerized to hexamers. They form quite stable self-pairing complexes in H2O as indicated by temperature dependent UV and CD spectroscopy.

  DOI：

  10.1002/1522-2675(200211)85:11<3855::aid-hlca3855>3.0.co;2-a

文献信息

• Nucleo--Amino Acids: Synthesis and Oligomerization to -Homoalanyl-PNA
  作者：Arndt M. Brückner、Harald W. Schmitt、Ulf Diederichsen

  DOI：10.1002/1522-2675(200211)85:11<3855::aid-hlca3855>3.0.co;2-a

  日期：2002.11

  The synthesis of thyminyl-, uracilyl-, cytosinyl-, and guaninyl-beta(3)-amino acids and the oligomerization of the cytosinyl- and guaninyl-beta(3)-amino acids to beta-homoalanyl-PNA are presented. The pyrimidinyl nucleobases were connected to the gamma-position of beta-homoalanine by Mitsunobu reaction with a beta-homoserine derivative or by nucleophilic substitution of methanesulfonates. For the preparation of the guaninyl-beta(3)-amino acid, a beta-lactam route was established that might be of interest also for the synthesis of other beta(3)-amino acid derivatives. The cytosinyl and guaninyl building blocks were oligomerized to hexamers. They form quite stable self-pairing complexes in H2O as indicated by temperature dependent UV and CD spectroscopy.