1-(6-Bromo-2,3-dihydro-1H-inden-1-yl)pyrrolidine | 371251-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1-(6-Bromo-2,3-dihydro-1H-inden-1-yl)pyrrolidine
• CAS: 371251-14-8
• 化学式: C₁₃H₁₆BrN
• 分子量: 266.181
• InChiKey: IXGFXBANYPFAPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(6-Bromo-2,3-dihydro-1H-inden-1-yl)pyrrolidine 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 四丁基氟化铵 、 二乙胺 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 20.0~120.0 ℃ 、206.84 kPa 条件下， 生成 2-[2, 3-Dihydro-3-(1-pyrrolidinyl)-1H-inden-5-yl]-7-methoxy-6-(5-oxazolyl)-4 (1H)-quinolinone
  参考文献：
  名称：

  Quinolone-Based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues

  摘要：

  The synthesis and the structure-activity relationships (SAR) of analogues derived from the introduction of basic residues on ring D of quinolone based inhibitors of IMPDH are described. This led to the identification of compound 27 as a potent inhibitor of IMPDH with significantly improved aqueous solubility over the lead compound 1. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00945-9
• 作为产物：
  描述：

  6-溴茚酮 在 sodium tetrahydroborate 、 氯化亚砜 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 1-(6-Bromo-2,3-dihydro-1H-inden-1-yl)pyrrolidine
  参考文献：
  名称：

  Quinolone-Based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues

  摘要：

  The synthesis and the structure-activity relationships (SAR) of analogues derived from the introduction of basic residues on ring D of quinolone based inhibitors of IMPDH are described. This led to the identification of compound 27 as a potent inhibitor of IMPDH with significantly improved aqueous solubility over the lead compound 1. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00945-9

文献信息

• Heterocycles that are inhibitors of IMPDH enzyme
  申请人：——

  公开号：US20020040022A1

  公开（公告）日：2002-04-04

  Compounds of the formula 1 wherein X 1 is C(O), —S(O)—, or —S(O) 2 —; X 2 is CR 3 or N; X 3 is —NH—, —O—, or —S—; X 4 is CR 4 or N; X 5 is CR 5 or N; and X 6 is CR 6 or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH-associated disorders.

  公式1中的化合物，其中X1是C(O)、—S(O)—或—S(O)2—；X2是CR3或N；X3是—NH—、—O—或—S—；X4是CR4或N；X5是CR5或N；X6是CR6或N，可用作IMPDH酶的抑制剂。因此，这些化合物可作为治疗IMPDH相关疾病的治疗剂。
• Rhodium catalysts derived from a fluorinated phanephos ligand are highly active catalysts for direct asymmetric reductive amination of secondary amines
  作者：Sophie H. Gilbert、Sergey Tin、José A. Fuentes、Tamara Fanjul、Matthew L. Clarke

  DOI：10.1016/j.tet.2020.131863

  日期：2021.1

  An asymmetric hydrogenation of enamines is efficiently catalysed by rhodium complexed with a fluorinated version of the planar chiral paracyclophane-diphosphine ligand, Phanephos. This catalyst was shown to be very active, with examples operating at just 0.1 mol% of catalyst. This catalyst was then successfully adapted to Direct Asymmetric Reductive Amination, leading to the formation of several tertiary

  铑与平面手性对环烷二膦配体Phanephos的氟化形式络合，有效地催化了烯胺的不对称氢化。该催化剂显示出非常高的活性，实施例仅在催化剂的0.1mol％下操作。然后，如果使用活化的酮/胺配偶体，则该催化剂成功地适应于直接不对称还原胺化反应，导致形成几种具有中等ee的叔胺。
• US6919335B2
  申请人：——

  公开号：US6919335B2

  公开（公告）日：2005-07-19
• Quinolone-Based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues
  作者：T.G.Murali Dhar、Scott H. Watterson、Ping Chen、Zhongqi Shen、Henry H. Gu、Derek Norris、Marianne Carlsen、Kristin D. Haslow、William J. Pitts、Junqing Guo、John Chorba、Catherine A. Fleener、Katherine A. Rouleau、Robert Townsend、Diane Hollenbaugh、Edwin J. Iwanowicz

  DOI：10.1016/s0960-894x(02)00945-9

  日期：2003.2

  The synthesis and the structure-activity relationships (SAR) of analogues derived from the introduction of basic residues on ring D of quinolone based inhibitors of IMPDH are described. This led to the identification of compound 27 as a potent inhibitor of IMPDH with significantly improved aqueous solubility over the lead compound 1. (C) 2002 Elsevier Science Ltd. All rights reserved.