1-(6-Bromo-2,3-dihydro-1H-inden-1-yl)pyrrolidine | 371251-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1-(6-Bromo-2,3-dihydro-1H-inden-1-yl)pyrrolidine
• CAS: 371251-14-8
• 化学式: C₁₃H₁₆BrN
• 分子量: 266.181
• InChiKey: IXGFXBANYPFAPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(6-Bromo-2,3-dihydro-1H-inden-1-yl)pyrrolidine 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 四丁基氟化铵 、 二乙胺 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 20.0~120.0 ℃ 、206.84 kPa 条件下， 生成 2-[2, 3-Dihydro-3-(1-pyrrolidinyl)-1H-inden-5-yl]-7-methoxy-6-(5-oxazolyl)-4 (1H)-quinolinone
  参考文献：
  名称：

  Quinolone-Based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues

  摘要：

  The synthesis and the structure-activity relationships (SAR) of analogues derived from the introduction of basic residues on ring D of quinolone based inhibitors of IMPDH are described. This led to the identification of compound 27 as a potent inhibitor of IMPDH with significantly improved aqueous solubility over the lead compound 1. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00945-9
• 作为产物：
  描述：

  6-溴茚酮 在 sodium tetrahydroborate 、 氯化亚砜 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 1-(6-Bromo-2,3-dihydro-1H-inden-1-yl)pyrrolidine
  参考文献：
  名称：

  Quinolone-Based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues

  摘要：

  The synthesis and the structure-activity relationships (SAR) of analogues derived from the introduction of basic residues on ring D of quinolone based inhibitors of IMPDH are described. This led to the identification of compound 27 as a potent inhibitor of IMPDH with significantly improved aqueous solubility over the lead compound 1. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00945-9

文献信息

• Heterocycles that are inhibitors of IMPDH enzyme
  申请人：——

  公开号：US20020040022A1

  公开（公告）日：2002-04-04

  Compounds of the formula 1 wherein X 1 is C(O), —S(O)—, or —S(O) 2 —; X 2 is CR 3 or N; X 3 is —NH—, —O—, or —S—; X 4 is CR 4 or N; X 5 is CR 5 or N; and X 6 is CR 6 or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH-associated disorders.

  公式1中的化合物，其中X1是C(O)、—S(O)—或—S(O)2—；X2是CR3或N；X3是—NH—、—O—或—S—；X4是CR4或N；X5是CR5或N；X6是CR6或N，可用作IMPDH酶的抑制剂。因此，这些化合物可作为治疗IMPDH相关疾病的治疗剂。
• Rhodium catalysts derived from a fluorinated phanephos ligand are highly active catalysts for direct asymmetric reductive amination of secondary amines
  作者：Sophie H. Gilbert、Sergey Tin、José A. Fuentes、Tamara Fanjul、Matthew L. Clarke

  DOI：10.1016/j.tet.2020.131863

  日期：2021.1

  An asymmetric hydrogenation of enamines is efficiently catalysed by rhodium complexed with a fluorinated version of the planar chiral paracyclophane-diphosphine ligand, Phanephos. This catalyst was shown to be very active, with examples operating at just 0.1 mol% of catalyst. This catalyst was then successfully adapted to Direct Asymmetric Reductive Amination, leading to the formation of several tertiary

  铑与平面手性对环烷二膦配体Phanephos的氟化形式络合，有效地催化了烯胺的不对称氢化。该催化剂显示出非常高的活性，实施例仅在催化剂的0.1mol％下操作。然后，如果使用活化的酮/胺配偶体，则该催化剂成功地适应于直接不对称还原胺化反应，导致形成几种具有中等ee的叔胺。
• US6919335B2
  申请人：——

  公开号：US6919335B2

  公开（公告）日：2005-07-19