8-hydroxy-7-nitro-quinoline-5-sulfonic acid | 15851-63-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-hydroxy-7-nitro-quinoline-5-sulfonic acid
• 英文别名: 7-Nitro-8-chinolinol-5-sulfonsaeure；8-Hydroxy-7-nitroquinoline-5-sulfonic acid
• CAS: 15851-63-5
• 化学式: C₉H₆N₂O₆S
• 分子量: 270.222
• InChiKey: QSIZKIGPOVCSFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  142
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  8-hydroxy-7-nitro-quinoline-5-sulfonic acid 在 三氯氧磷 作用下， 生成 8-chloro-7-nitroquinoline-5-sulfonyl chloride
  参考文献：
  名称：

  WO2008/129276

  摘要：

  公开号：
• 作为产物：
  描述：

  8-羟基喹啉 在 硫酸 、 potassium nitrate 作用下， 反应 38.0h， 生成 8-hydroxy-7-nitro-quinoline-5-sulfonic acid
  参考文献：
  名称：

  取代8-羟基喹啉锌配合物的荧光性质与结构关系的研究。

  摘要：

  由8-羟基喹啉金属络合物生产的有机发光二极管（OLED）在现代电致发光器件中起着至关重要的作用。本文采用不同的方法合成了一系列的8-羟基喹啉衍生物，并制备了相应的锌金属配合物。测量了配合物的紫外和荧光性质，旨在了解喹啉环上的取代基对配合物的荧光性质的影响。当8-羟基喹啉的C-5被卤素取代时，荧光发射波长发生了红移，同时，当8-羟基喹啉的C-5位置为2时，观察到荧光发射波长发生了蓝移。被吸电子基团取代。

  DOI：

  10.1007/s10895-018-2275-7

文献信息

• Theoretical and experimental studies on the fluorescence properties of aluminum(III), cadmium(II), zinc(II), and copper(II) complexes of substituted 8-hydroxyquinoline
  作者：Zhang Yuanyuan、Cheng Hongrui、Sun Qingrong、Chen Hongli、Yang Weiqing、Ma Menglin

  DOI：10.1177/1747519820973601

  日期：2021.5

  Fifty-five 8-hydroxyquinoline (8-HQ) derivatives are synthesized and the corresponding aluminum(III), cadmium(II), copper(II), and zinc(II) metal complexes are prepared and their fluorescent activi...

  合成了55种8-羟基喹啉（8-HQ）衍生物并制备了相应的铝（III）、镉（II）、铜（II）和锌（II）金属配合物及其荧光活性...
• Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines
  作者：Robert Musiol、Josef Jampilek、Jacek Nycz、Matus Pesko、James Carroll、Katarina Kralova、Marcela Vejsova、Jim O'Mahony、Aidan Coffey、Anna Mrozek、Jaroslaw Polanski

  DOI：10.3390/molecules15010288

  日期：——

  of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed

  在这项研究中，制备了一系列十四个环取代的 8-羟基喹啉衍生物。介绍了合成程序。使用RP-HPLC分析化合物以确定亲脂性。测试了它们与菠菜 (Spinacia oleracea L.) 叶绿体中光合电子传递 (PET) 抑制相关的活性。还针对四种分枝杆菌菌株和八种真菌菌株对合成化合物进行了初步体外筛选。几种化合物显示出与标准异烟肼或氟康唑相当或更高的生物活性。对于所有化合物，讨论了所研究化合物的亲脂性和化学结构之间的关系。
• [EN] 7-NITRO-8-HYDROXYQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF<br/>[FR] DÉRIVÉ DE 7-NITRO-8-HYDROXYQUINOLÉINE, SON PROCÉDÉ DE PRÉPARATION ET UTILISATION MÉDICALE ASSOCIÉE<br/>[ZH] 7-硝基-8-羟基喹啉衍生物、其制备方法及其医药用途
  申请人：JIANGSU YAHONG MEDITECH CO LTD

  公开号：WO2022253152A1

  公开（公告）日：2022-12-08

  一种7-硝基-8-羟基喹啉衍生物、其制备方法及其医药用途。具体地，通式(I)所示的化合物、其制备方法、含有其的药物组合物，以及其在治疗感染性疾病或癌症中的用途。所述化合物具有优异的抗菌和抗肿瘤活性，可以被开发为治疗感染性疾病或肿瘤的药物。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。