9-bromo-decane-1-ol | 1275582-65-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 9-bromo-decane-1-ol
• 英文别名: 9-bromodecan-1-ol；9-bomodecan-1-ol；9-bromodecanol
• CAS: 1275582-65-4
• 化学式: C₁₀H₂₁BrO
• 分子量: 237.18
• InChiKey: NZERIIPIHFACPK-UHFFFAOYSA-N

物化性质

• 沸点：
  282.8±13.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯,[(9-癸烯氧基)甲基]- 在 三苯基膦氢溴酸盐 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以63%的产率得到9-十烯-1-醇
  参考文献：
  名称：

  三苯基膦氢溴酸盐裂解苄基醚

  摘要：

  发现三苯基膦氢溴酸盐以良好的产率将衍生自1°，2°烷基和芳基醇的苄基醚裂解为相应的醇和苄基三苯基溴化phosph。分别由具有3°烷基和烯丙基的苄基醚制备烯烃和烯丙基phospho盐。这些结果表明产物的形成取决于碳阳离子中间体的相对稳定性。化学计量的无水PPh 3 ·HBr为苄醚的脱保护提供了一种新的有效方法。

  DOI：

  10.1016/j.tetlet.2010.09.065

文献信息

• Synthesis, structural characterization and catalytic activity of a multifunctional enzyme mimetic oxoperoxovanadium(v) complex
  作者：Tapan K. Si、Shiv S. Paul、Michael G. B. Drew、Kalyan K. Mukherjea

  DOI：10.1039/c2dt12505f

  日期：——

  as well as nuclease activity through effective interaction with DNA. The complex is the first example of a structurally characterized stable oxoperoxovanadium(V) complex with a coordinated bi-dentate hydroximate moiety (–CONHO−) from 2-phenylacetohydroximate (PAH). The oxoperoxovanadium(V) complex has been used as catalyst for the peroxidative bromination reaction of some unsaturated alcohols (e.g. 4-pentene-1-ol

  已完成了一种新型的含配体2-苯基乙酰氧肟酸（PAHH）和1,10-菲咯啉（phen）的氧过氧钒（V）配合物[VO（O 2）（PAH）（phen）]的合成和结构表征。发现过氧过氧钒（V）复合物通过与DNA的有效相互作用模拟了钒酸盐依赖性的过氧化物酶（VHPO）活性和核酸酶活性。该复合物是一种结构特征在于稳定oxoperoxovanadium（的第一例V）络合物与协调二齿hydroximate部分（-CONHO - ）由2- phenylacetohydroximate（PAH）。氧过氧钒（V）配合物已被用作在H 2 O 2存在下某些不饱和醇（例如4-戊烯-1-醇，1-辛烯-3-醇和9-癸烯-1-醇）的过氧化溴化反应的催化剂和KBr。催化产物已通过GC-MS分析和分光光度法进行了表征。该复合物的DNA结合已通过CT DNA建立，而DNA裂解已通过质粒DNA证实。复合物与DNA的相互作用已通过电
• Pyrrole-Type compounds, compositions, and methods for treating cancer or viral diseases
  申请人：Gemin X Biotechnologies Inc.

  公开号：US20040014987A1

  公开（公告）日：2004-01-22

  The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.

  本发明涉及新型吡咯烷类化合物，包含吡咯烷类化合物的组合物，以及用于治疗或预防癌症或肿瘤性疾病的方法，包括给予含有吡咯烷类化合物的组合物。本发明的化合物、组合物和方法还可用于抑制癌细胞或肿瘤细胞的生长。本发明还涉及新型吡咯烷类化合物、组合物和用于治疗或预防病毒感染的方法。本发明的化合物、组合物和方法还可用于抑制病毒的复制和/或传染性。
• Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases
  申请人：——

  公开号：US20030009032A1

  公开（公告）日：2003-01-09

  The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.

  本发明涉及一种新型吡咯类化合物，包含吡咯类化合物的组合物以及用于治疗或预防癌症或肿瘤性疾病的方法，其中包括给予包含吡咯类化合物的组合物。本发明的化合物、组合物和方法还可用于抑制癌细胞或肿瘤细胞的生长。本发明还涉及一种新型吡咯类化合物、组合物和方法，用于治疗或预防病毒感染。本发明的化合物、组合物和方法还可用于抑制病毒的复制和/或感染能力。
• Pyrrole-Type compounds, compositions and methods for treating cancer or viral disease
  申请人：Johnson A. Roy

  公开号：US20070037856A1

  公开（公告）日：2007-02-15

  The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.

  本发明涉及新型吡咯类化合物、含有吡咯类化合物的组合物以及用于治疗或预防癌症或肿瘤性疾病的方法，包括给予含有吡咯类化合物的组合物。本发明的化合物、组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长。本发明还涉及新型吡咯类化合物、组合物和方法，用于治疗或预防病毒感染。本发明的化合物、组合物和方法也可用于抑制病毒的复制和/或感染能力。
• Prodigiosin derivatives for treating cancer or viral diseases
  申请人：Gemin X Biotechnologies Inc.

  公开号：EP1431286A2

  公开（公告）日：2004-06-23

  The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.

  本发明涉及新型吡咯类化合物、包含吡咯类化合物的组合物，以及用于治疗或预防癌症或肿瘤性疾病的方法，其中包含施用包含吡咯类化合物的组合物。本发明的化合物、组合物和方法还可用于抑制癌细胞或肿瘤细胞的生长。本发明还涉及治疗或预防病毒感染的新型吡咯类化合物、组合物和方法。本发明的化合物、组合物和方法还可用于抑制病毒的复制和/或传染性。