2-bromo-2-phenoxy-1-phenyl-ethanone | 54720-57-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-bromo-2-phenoxy-1-phenyl-ethanone
• 英文别名: 2-Brom-2-phenoxy-1-phenyl-aethanon；2-bromo-2-phenoxyacetophenone；2-bromo-2-phenoxy-1-phenylethanone
• CAS: 54720-57-9
• 化学式: C₁₄H₁₁BrO₂
• 分子量: 291.144
• InChiKey: HXHWNCUSNHDLFZ-UHFFFAOYSA-N

物化性质

• 熔点：
  45 °C
• 沸点：
  387.6±32.0 °C(Predicted)
• 密度：
  1.434±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromo-2-phenoxy-1-phenyl-ethanone 在 吡啶 、 溴 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 2-[(4-anilino-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-2-bromo-2-phenoxy-1-phenylethanone
  参考文献：
  名称：

  Chande, Madhukar S.; Joshi, Vishvas R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1995, vol. 34, # 2, p. 147 - 150

  摘要：

  DOI：
• 作为产物：
  描述：

  2’-苯氧基苯乙酮 在 溴 作用下， 以 氯仿 为溶剂， 以85%的产率得到2-bromo-2-phenoxy-1-phenyl-ethanone
  参考文献：
  名称：

  Chande; Karnik; Inamdar, Journal of the Indian Chemical Society, 1990, vol. 67, # 3, p. 220 - 222

  摘要：

  DOI：

文献信息

• New Heterocyclic Precursors for Thermal Generation of Reactive, Electron-Rich 1,2-Diaza-1,3-butadienes
  作者：Robert K. Boeckman,、Ping Ge、Jessica E. Reed

  DOI：10.1021/ol0165645

  日期：2001.11.1

  [reaction--see text] [corrected] The preparation and thermolysis of new stable heterocyclic precursors of 1,2-diaza-1,3-butadienes is described. The resulting reactive diazadienes are trapped in situ with N-phenylmaleimide [corrected]. The effect of precursor structure on the temperature at which the diazadienes are generated is discussed.

  [反应-见正文] [已更正]描述了1,2-二氮杂-1,3-丁二烯新的稳定杂环前体的制备和热解。生成的反应性二氮杂二烯被N-苯基马来酰亚胺原位捕获[校正]。讨论了前体结构对生成二氮杂二烯的温度的影响。
• [2(4,5-diaryl-2 oxazoyl substituted phenoxy alkanoic acid and esters
  申请人：Bristol-Myers Squibb Company

  公开号：US05262540A1

  公开（公告）日：1993-11-16

  Oxazole derivatives having Formula I or II are disclosed which are useful as inhibitors of mammalian blood platelet aggregation. ##STR1## Formula I and Formula XIX compounds are those wherein n is 7-9 and R is hydrogen or lower alkyl. Formula II compounds are those wherein R is hydrogen, lower alkyl or together with CO.sub.2 is tetrazol-1-yl; R.sub.1 is phenyl or thienyl; X is a divalent connecting group selected from the group consisting of CH.sub.2 CH.sub.2, CH.dbd.CH, and CH.sub.2 O; Y is a divalent connecting group attached to the 3 or 4 phenyl position selected from the group consisting of OCH.sub.2, CH.sub.2 CH.sub.2 and CH.dbd.CH. Formula XX compounds are those wherein the OCH.sub.2 CO.sub.2 R moiety is attached to the 3 or 4 phenyl position and R is hydrogen or lower alkyl.

  本申请公开了具有式I或II的噁唑衍生物，其可用作哺乳动物血小板聚集的抑制剂。其中，式I和式XIX化合物中n为7-9，R为氢或低碳基。式II化合物中，R为氢、低碳基或与CO.sub.2一起为四唑-1-基；R.sub.1为苯基或噻吩基；X为从CH.sub.2 CH.sub.2、CH.dbd.CH和CH.sub.2 O组成的双价连接基；Y为连接到3或4苯基位置的双价连接基，从OCH.sub.2、CH.sub.2 CH.sub.2和CH.dbd.CH组成。式XX化合物中，OCH.sub.2 CO.sub.2 R基团连接到3或4苯基位置，R为氢或低碳基。
• Alkoxyiminoacetamide derivatives and their use as fungicides
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

  公开号：EP0398692A2

  公开（公告）日：1990-11-22

  A fungicidal composition for agricultural use, which comprises a compound of the formula: wherein R1 and R2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R3 is lower alkyl or cyclo(lower)alkyl; R4 and R5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, said phenyl group or heterocyclic group being optionally substituted with not more than three substituents; and Z is -CH2-, -CH(OH)-, -CO-, -O-, -S-, -SO-, -NR- (R being hydrogen or lower alkyl), -CH2CH2-, -CH = CH-, -CH20-, -CH2S-, CH2S0-, -OCH2-, -SCH2- or -SOCH2-.

  一种农用杀菌组合物，它包括一种式化合物： 其中 R1 和 R2 分别是氢、低级烷基或环（低级）烷基；R3 是低级烷基或环（低级）烷基；R4 和 R5 分别是氢、低级烷基、低级烷氧基、卤素取代的低级烷基、低级烷基取代的硅基、卤素或硝基；A 代表不饱和烃基、卤素取代的不饱和烃基、苯基或杂环基，所述苯基或杂环基可选择被不多于三个取代基取代；以及 Z 是-CH2-、-CH(OH)-、-CO-、-O-、-S-、-SO-、-NR-（R 为氢或低级烷基）、-CH2CH2-、-CH = CH-、-CH = CH20-、-CH = CH20-、-CH = CH20-、-CH = CH20-、-CH = CH20-、-CH = CH20-、-CH = CH20-、-CH = CH20-、-CH = CH20-、-CH = CH20-、 -CH20-、-CH2S-、CH2S0-、-OCH2-、-SCH2- 或 -SOCH2-。
• Oxazole derivatives
  申请人：Bristol-Myers Squibb Company

  公开号：EP0434034A1

  公开（公告）日：1991-06-26

  Oxazole derviatives having Formula I or II are disclosed which are useful as inhibitors of mammalian blood platelet aggregation. Formula I and Formula XIX compounds are those wherein n is 7-9 and R is hydrogen or lower alkyl. Formula II compounds are those wherein R is hydrogen, lower alkyl or together with C02 is tetrazol-1-yl; R1 is phenyl or thienyl; X is a divalent connecting group selected from the group consisting of CH2CH2, CH = CH, and CH20; Y is a divalent connecting group attached to the 3 or 4 phenyl position selected from the group consisting of OCH2, CH2CH2 and CH=CH. Formula XX compounds are those wherein the OCH2C02R moiety is attached to the 3 or 4 phenyl position and R is hydrogen or lower alkyl.

  本研究公开了具有式 I 或式 II 的噁唑衍生物，它们可用作哺乳动物血小板聚集的抑制剂。 式 I 和式 XIX 化合物为其中 n 为 7-9 和 R 为氢或低级烷基的化合物。式 II 化合物为其中 R 为氢、低级烷基或与 C02 一起为四唑-1-基；R1 为苯基或噻吩基；X 为选自 CH2CH2、CH＝CH 和 CH20 的二价连接基团；Y 为连接到 3 或 4 苯基位置的选自 OCH2、CH2CH2 和 CH＝CH 的二价连接基团。式 XX 化合物是指 OCH2C02R 分子连接到 3 或 4 苯基位置且 R 为氢或低级烷基的化合物。
• Process for the preparation of Alkoxyiminoacetamide derivatives and an intermediate therefor
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

  公开号：EP0629609A1

  公开（公告）日：1994-12-21

  A process for preparing a compound of the formula: wherein A is a phenyl group or a heterocyclic group, said phenyl group and said heterocyclic group being optionally substituted with not more than three substituents, which comprises reacting a compound of the formula: with an aryl halide in the presence of a base. The resulting compound (A) is useful as a fungicide. There is also disclosed a compound of the formula:

  一种制备式化合物的工艺： 其中 A 是苯基或杂环基团，所述苯基和杂环基团可任选被不超过三个取代基取代，该工艺包括使以下式子的化合物发生反应 与芳基卤化物在碱存在下反应。所得化合物（A）可用作杀真菌剂。还公开了一种式化合物：