sodium 1,3-thiazole-2-thiolate | 40003-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: sodium 1,3-thiazole-2-thiolate
• 英文别名: 3H-thiazole-2-thione; sodium salt；Sodium;1,3-thiazole-2-thiolate
• CAS: 40003-49-4
• 化学式: C₃H₂NS₂*Na
• 分子量: 139.177
• InChiKey: KQEXNTGMPKKAAB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.95
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-溴-4-甲基-1,3-噻唑-5-甲酸乙酯 、 sodium 1,3-thiazole-2-thiolate 以 水 、 丙酮 为溶剂， 生成 4-methyl-2-thiazol-2-ylsulfanyl-thiazole-5-carboxylic acid ethyl ester
  参考文献：
  名称：

  Abdel-Lateef,M.F.-A.; Eckstein,Z., Roczniki Chemii, 1972, vol. 46, p. 1647 - 1658

  摘要：

  DOI：

文献信息

• [EN] 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES<br/>[FR] 3-AMINO-1,5,6,7-TÉTRAHYDRO-4H-INDOL-4-ONES
  申请人：BAYER PHARMA AG

  公开号：WO2016202755A1

  公开（公告）日：2016-12-22

  Compounds of formula (I) as described hereinprocesses for their production and their use as anti-cancer agents.

  本文描述的式(I)化合物，其生产方法及其作为抗癌药物的用途。
• Synthesis and Antithyroid Activity of Pyridine, Pyrimidine and Pyrazine Derivatives of Thiazole-2-thiol and 2-Thiazoline-2-thiol.
  作者：Jean-Francois LAGORCE、Francis COMBY、Annick ROUSSEAU、Jacques BUXERAUD、Claude RABY

  DOI：10.1248/cpb.41.1258

  日期：——

  A series of compounds was synthesized by linking various derivatives of pyridine, pyrimidine or pyrazine to thiazole-2-thiol or to its partially hydrogenated derivative 2-thiazoline-2-thiol. The reactions of the compounds with molecular iodine and lactoperoxidase were examined in vitro. Their antithyroid activity was also examined in vivo in the rat. T4 and TSH levels were determined, and the thyroid gland was examined histologically. 2-(3-Hydroxy-2-pyridyl)-2-thiothiazoline had the highest antithyroid activity of the compounds tested (Kc=14931·mol-1, IC500.65×10-4M, activity of thryoid gland +++).

  通过将吡啶、嘧啶或吡嗪的各种衍生物与噻唑-2-硫醇或其部分氢化衍生物 2-噻唑啉-2-硫醇连接，合成了一系列化合物。体外研究了这些化合物与分子碘和乳过氧化物酶的反应。还在大鼠体内检测了它们的抗甲状腺活性。测定了 T4 和 TSH 水平，并对甲状腺进行了组织学检查。在所测试的化合物中，2-（3-羟基-2-吡啶基）-2-噻唑啉的抗甲状腺活性最高（Kc=14931-mol-1，IC500.65×10-4M，甲状腺活性 +++）。
• Synthesis of new 3-thiosubstituted carbacephem antibiotics and their activity against penicillin resistant Streptococcus pneumoniae
  作者：Larry C. Blaszczak、Clark N. Eid、Jane Flokowitsch、G.Stuart Gregory、Stephen A. Hitchcock、George W. Huffman、Daniel R. Mayhugh、Michael J. Nesler、David A. Preston、Mohammad Zia-Ebrahimi

  DOI：10.1016/s0960-894x(97)00412-5

  日期：1997.9

  The synthesis of a series of 3-thiosubstituted carbacephem derivatives is described. The compounds were assayed against penicillin susceptible, intermediate and resistant strains of Streptococcus pneumoniae. Several analogs displayed potent in vitro activity against these organisms. (C) 1997 Elsevier Science Ltd.
• Lagorce JeanFrancois, Comby Francis, Rousseau Annick, Buxeraud Jacques, R+, Chem. and Pharm. Bull, 41 (1993) N 7, S 1258-1260
  作者：Lagorce JeanFrancois, Comby Francis, Rousseau Annick, Buxeraud Jacques, R+

  DOI：——

  日期：——