1-[2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethoxy]-2-ethoxyethane | 935701-71-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethoxy]-2-ethoxyethane
• 英文别名: 1-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]-2-ethoxyethane
• CAS: 935701-71-6
• 化学式: C₁₂H₂₅BrO₅
• 分子量: 329.231
• InChiKey: XZOWOUBYMKYUKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-[2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethoxy]-2-ethoxyethane 、 N-boc-4,4-联哌啶 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以10%的产率得到tert-butyl 1'-(3,6,9,12,15-pentaoxaheptadecyl)-[4,4'-bipiperidine]-1-carboxylate
  参考文献：
  名称：

  [35S]GTPγS binding studies of amphiphilic drugs-activated Gi proteins: A caveat

  摘要：

  This paper documents a serious problem met during the testing of Gi protein-activating properties of a new series of synthetic compounds by measuring the induced binding of [(35)S]GTP gamma S to different subtypes of Gi protein. The problem arose from the strong affinity between [(35)S]GTP gamma S and the tested compounds, that are characterized by several (2-4) positive charges and high lipophilicity. Apparently, such affinity yields insoluble, labelled complexes that, also in the absence of Gi protein, are retained on the filters and give rise to false positive results. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.097

文献信息

• 一种治疗白内障的化合物及其组合物、制备方法和医药用途
  申请人：深圳弘汇生物医药有限公司

  公开号：CN113801180A

  公开（公告）日：2021-12-17

  本发明公开了一种治疗白内障的化合物及其组合物、制备方法和医药用途，所述化合物具有式I所示结构(n为1‑50)。本发明化合物可用于治疗白内障等晶状体混浊性疾病。
• [35S]GTPγS binding studies of amphiphilic drugs-activated Gi proteins: A caveat
  作者：Dina Manetti、Lorenzo Di Cesare Mannelli、Silvia Dei、Luca Guandalini、Elisabetta Martini、Martina Banchelli、Carla Ghelardini

  DOI：10.1016/j.bmcl.2009.02.097

  日期：2009.4

  This paper documents a serious problem met during the testing of Gi protein-activating properties of a new series of synthetic compounds by measuring the induced binding of [(35)S]GTP gamma S to different subtypes of Gi protein. The problem arose from the strong affinity between [(35)S]GTP gamma S and the tested compounds, that are characterized by several (2-4) positive charges and high lipophilicity. Apparently, such affinity yields insoluble, labelled complexes that, also in the absence of Gi protein, are retained on the filters and give rise to false positive results. (c) 2009 Elsevier Ltd. All rights reserved.