7-(2-Ethyl-1-Hexen-1-yl)-8-quinolinol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(2-Ethyl-1-Hexen-1-yl)-8-quinolinol
• 英文别名: 7-[(E)-2-ethylhex-1-enyl]quinolin-8-ol
• 化学式: C₁₇H₂₁NO
• 分子量: 255.36
• InChiKey: KVXNGMXXHWBFRX-OUKQBFOZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  8-羟基喹啉 、 2-乙基已基醛 以 水 、 甲苯 为溶剂， 生成 7-(2-Ethyl-1-Hexen-1-yl)-8-quinolinol
  参考文献：
  名称：

  Substituted 8-hydroxyquinolines and process for the preparation thereof

  摘要：

  一类羟基喹啉的烃基取代物，其中所示取代基是通过采用障碍醛对该喹啉酚进行间接烷基化而产生的。这些烷基化物在水冶提取过程中是有用的金属收集剂，旨在从稀释的水溶液中回收金属价值。

  公开号：

  US04066652A1

文献信息

• Substituted 8-hydroxyquinolines and process for the preparation thereof
  申请人：Ashland Oil, Inc.

  公开号：US04066652A1

  公开（公告）日：1978-01-03

  A class of hydrocarbyl substituted 8-hydroxyquinolines wherein the indicated substituent arises through the indirect alkylation of said quinolinol with a hindered aldehyde. These alkylates are useful metal collectors in hydrometallurgical extraction processes designed for the recovery of metal values from dilute aqueous solutions thereof.

  一类羟基喹啉的烃基取代物，其中所示取代基是通过采用障碍醛对该喹啉酚进行间接烷基化而产生的。这些烷基化物在水冶提取过程中是有用的金属收集剂，旨在从稀释的水溶液中回收金属价值。
• [EN] METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS<br/>[FR] PROCÉDÉ POUR TRAITER DES INFECTIONS BACTÉRIENNES RÉSISTANT AU MÉDICAMENT ET D'AUTRES INFECTIONS PAR DU CLIOQUINOL, DE LA PHANQUINONE ET DES COMPOSÉS APPARENTÉS
  申请人：XILINAS MICHEL E

  公开号：WO2009140215A2

  公开（公告）日：2009-11-19

  The invention relates to new uses of known chelating compounds for the treatment of bacterial in fungal infections, particularly by methicilllin-resistant and other drug-resistant strains of bacteria and fungi. One of more chelating compound is administered with or without additional antibiotic or antifungal drugs to achieve improved therapy. Preferred chelating compounds include clioquinol, 5,7-dichloro-8-hydroxy-quinaldine, phanquinone, 5,7-dichloro-8-hydroxyquinoline, 5,7- di-iodo-8-hydroxyquinoline. By chelation of specific metal ions, these compounds treat any infection by bacteria or fungi whose pathogenicity depends upon metalloenzymes that require these cations. The compounds are also effective against infections caused by extended β lactamase and metallo β lactamase producing bacterial strains. Bacteria targeted by these methods include methicillin-resistant Staphylococcus aureus, penicillin resistant or intermediate resistant Streptococcus pneumoniae and other gram positive and multiresistant gram negative species and strains.
• LIU, CHANG-JI;SHU, GUO-EN;YUAN, CHENG-YE, ACTA CHIM. SIN, 1983, 41, N 7, 654-658
  作者：LIU, CHANG-JI、SHU, GUO-EN、YUAN, CHENG-YE

  DOI：——

  日期：——