[(10R,13R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] tetradecanoate | 1989-52-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [(10R,13R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] tetradecanoate
• CAS: 1989-52-2
• 化学式: C₄₁H₇₂O₂
• 分子量: 597.0
• InChiKey: SJDMTGSQPOFVLR-ZVMQTDSHSA-N

物化性质

• 熔点：
  84 °C
• 沸点：
  589.77°C (rough estimate)
• 密度：
  0.9309 (rough estimate)
• 溶解度：
  氯仿（微溶）、己烷（微溶）
• LogP：
  16.656 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  15.4
• 重原子数：
  43
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 安全说明：
  S26,S36

制备方法与用途

生物活性

胆固醇肉豆蔻酸酯是中药中天然类固醇。它能与多种离子通道结合，例如 nAChR、GABAA 受体和内向整流钾离子通道。

靶点

Human Endogenous Metabolite

体外研究

在人骨髓间充质干细胞（MSCs）中通过 Id1 基因启动子报告基因构建物转染后，胆固醇肉豆蔻酸酯能增强 Id1 启动子的活性。它还能抑制由无血清诱导的 MSCs 凋亡，并增加无血清条件下 MSCs 中 Id1 和其靶基因 bcl-x/l 的表达。此外，BMP 抑制剂 noggin 可减少胆固醇肉豆蔻酸酯的抗凋亡效果。

同样地，在无血清条件下培养 PC12 细胞时，胆固醇肉豆蔻酸酯显著增强了 BMP4、BMPRIA、p-Smad1/5/8、Id1 以及其抗凋亡靶基因 Bcl-xL 的表达。

文献信息

• IONIZABLE COMPOUNDS AND COMPOSITIONS AND USES THEREOF
  申请人：Nitto Denko Corporation

  公开号：US20160376229A1

  公开（公告）日：2016-12-29

  This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

  这项发明涉及可离子化的化合物，以及其组合物和使用方法。这些可离子化的化合物可用于制备纳米粒子组合物，用于生物制药和治疗。更具体地说，这项发明涉及提供纳米粒子以包裹活性剂，如核酸剂，并将活性剂传递和分发到细胞、组织、器官和受试者的化合物、组合物和方法。
• Functional associative coatings for nanoparticles
  申请人：Hainfeld James F.

  公开号：US20080089836A1

  公开（公告）日：2008-04-17

  Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

  本文描述了一种纳米颗粒，其表面涂覆有由表面结合分子和两亲分子形成的双层分子层。该双层涂层可以自组装在纳米颗粒上，使用易得的材料/分子。双层涂层纳米颗粒的模块化设计提供了一种方便和高效地优化其性质的方法。此外，本文还描述了这种纳米颗粒在医学、实验室技术、工业和商业应用中的用途。
• CARBOXYLIC ACID-TYPE LIPID, AND LIPID PARTICLE AND LIPID MEMBRANE EACH COMPRISING CARBOXYLIC ACID-TYPE LIPID
  申请人：Toray Industries, Inc.

  公开号：US20210387943A1

  公开（公告）日：2021-12-16

  A carboxylic acid-type lipid can accelerate adhesion or aggregation of platelets even if the carboxylic acid-type lipid does not carry a protein involved in adhesion or aggregation of platelets or a peptide corresponding to an active site of the protein; a lipid particle and a lipid membrane each include the carboxylic acid-type lipid; and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane. A carboxylic acid-type lipid is selected from carboxylic acid-type lipids represented by formulas (I) to (VI), a lipid particle includes the carboxylic acid-type lipid, a lipid membrane includes the carboxylic acid-type lipid, and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane.

  一种羧酸型脂质即使不携带与血小板粘附或聚集有关的蛋白质或相应的蛋白质活性位点对血小板的粘附或聚集也能加速，脂质颗粒和脂质膜均包括该羧酸型脂质；血小板聚集加速剂、血小板粘附加速剂、止血剂和血小板替代物均包括该羧酸型脂质、脂质颗粒或脂质膜。所述羧酸型脂质选自公式（I）到（VI）所表示的羧酸型脂质，脂质颗粒包括该羧酸型脂质，脂质膜包括该羧酸型脂质，血小板聚集加速剂、血小板粘附加速剂、止血剂和血小板替代物均包括该羧酸型脂质、脂质颗粒或脂质膜。
• Alpha-Isomaltosylglucosaccharide synthase, process for producing the same and use thereof
  申请人：——

  公开号：US20030194762A1

  公开（公告）日：2003-10-16

  The object of the present invention is to provide an &agr;-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an &agr;-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the &agr;-1,6 glucosidic linkage as a linkage at the non-reducing end and the &agr;-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the &agr;-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the &agr;-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; &agr;-isomaltosyl-transferring method using the enzyme; method for forming &agr;-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{→6)-&agr;-D-glucopyranosyl-(1→3)-&agr;-D-glucopyranosyl-(1→6)-&agr;-D-glucopyranosyl-(1→3)-&agr;-D-glucopyranosyl-(1→} using both the &agr;-isomaltosylglucosaccharide-forming enzyme and the &agr;-isomaltosyl-transferring enzyme; and the uses of the saccharides obtainable therewith.

  本发明的目的是提供一种α-异麦芽糊精葡萄糖醛酸形成酶、其制备方法、环四糖和含有使用该酶可获得的糖分的糖组成物；并通过建立一种α-异麦芽糊精葡萄糖醛酸形成酶来解决该问题，该酶可形成一种葡萄糖聚合度至少为三且具有α-1,6葡萄糖苷键作为非还原端连接和α-1,4葡萄糖苷键作为非还原端连接以外的连接的糖分，通过催化具有至少二个葡萄糖聚合度且具有α-1,4葡萄糖苷键作为非还原端连接的糖分的α-葡萄糖基转移而形成，而不实质性地增加还原能力；使用该酶的α-异麦芽糊精转移方法；形成α-异麦芽糊精葡萄糖醛酸的方法；使用α-异麦芽糊精葡萄糖醛酸形成酶和α-异麦芽糊精转移酶同时制备具有环四糖结构的环四糖的方法；以及使用可获得的糖分的用途。
• AMINO ACID LIPIDS AND USES THEREOF
  申请人：Quay Steven C.

  公开号：US20080317839A1

  公开（公告）日：2008-12-25

  This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

  这份披露提供了一系列氨基酸脂类化合物和组合物，可用于药物传递、治疗、诊断和治疗疾病和病况。这些氨基酸脂类化合物和组合物可用于将各种药剂如核酸治疗剂传递到细胞、组织、器官和受试者中。