The present invention relates to 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.
本发明涉及抑制炎症细胞因子的胞外释放的1,1,3-三取代
脲类化合物,该细胞因子负责一个或多个人类或更高级哺乳动物疾病状态。本发明还涉及包含所述1,1,3-三取代
脲类化合物的组合物,该组合物抑制炎症细胞因子的胞外释放,并用于预防、减轻或以其他方式控制被认为是导致所述疾病状态的活性成分的酶的方法。