(4R*,9S*,10S*)-tricyclo<8.4.0.0^4,9>tetradec-1(2)-en-3-one | 18938-05-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (4R*,9S*,10S*)-tricyclo<8.4.0.0^4,9>tetradec-1(2)-en-3-one
• 英文别名: (+/-)-9-oxo-(4arH.4btH.8acH)-1.2.3.4.4a.4b.5.6.7.8.8a.9-dodecahydro-phenanthrene；(+/-)-9-Oxo-(4arH.4btH.8acH)-1.2.3.4.4a.4b.5.6.7.8.8a.9-dodecahydro-phenanthren；(4aS,4bS,8aR)-2,3,4,4a,4b,5,6,7,8,8a-decahydro-1H-phenanthren-9-one
• CAS: 18938-05-1；116415-59-9；116415-60-2
• 化学式: C₁₄H₂₀O
• 分子量: 204.312
• InChiKey: JRMDUKMUBDZKCX-FRRDWIJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914299000

反应信息

• 作为反应物：
  描述：

  (4R*,9S*,10S*)-tricyclo<8.4.0.0^4,9>tetradec-1(2)-en-3-one 在 臭氧 、 溶剂黄146 作用下， 生成 (1RS:1'RS)-2'-oxo-(1rH)-bicyclohexyl-carboxylic acid-(2c)
  参考文献：
  名称：

  Massive pulmonary embolism: a comparison of radiological and clinical characteristics and outcomes

  摘要：

  Study objectives: To describe the clinical features of radiographically massive pulmonary embolism (MPE). Design: Retrospective analysis. Setting: A 1,368-bed teaching hospital. Patients or participants: Patients with pulmonary embolism between June 1997 and December 1999. Interventions: Radiographic reports of patients with a radiographic diagnosis of pulmonary embolism were reviewed to determine whether MPE (>50% vascular occlusion) was present. For patients with MPE, vital signs, respiratory and cardiac symptoms, medical history, arterial blood gases, electrocardiographic (ECG) and echocardiographic results, treatment, and hospital mortality were recorded. Measurements and results: Fifty-four patients with MPE were identified. Patient age range was 28-91 years (mean 71 years). Symptoms were: dyspnea in 38 (70%), chest pain in 21 (38%), syncope in 12 (22%), palpitations in 6 (11%), systolic blood pressure <90 mmHg in 12 (22%), tachycardia (>120 beats/min) in 15 (28%) and tachypnea (respiratory rate >30) in 15 (28%). Pa O(2) (arterial partial pressure of oxygen) was less than 60 mmHg in 28 (71%) and the alveolar-arterial oxygen gradient was always greater than 20. ECG had an S1Q3T3 pattern in 6 (12%). Echocardiography revealed right ventricular dilatation in 12/31 (38%). Forty-nine patients received anticoagulation treatment, 4 (7%) received thrombolytic therapy with anticoagulation, 5 had inferior vena cava filters (IVC) alone, 6 received IVC filters with anticoagulation, and 2 received thrombolytic therapy, anticoagulation, and IVC filters. Eighteen (33%) patients were treated in the intensive care unit, 3 (5.5%) with mechanical ventilation. Fifty (93%) patients were eventually discharged and 4 (7%) died. Two of the deaths were not attributable to MPE. Conclusions: Patients with MPE usually present with dyspnea and hypoxemia, and most survive without thrombolytic therapy.

  DOI：

  10.1007/s10140-002-0198-7
• 作为产物：
  描述：

  环己酮 在 乙醚 、 sodium amide 作用下， 生成 (4R*,9S*,10S*)-tricyclo<8.4.0.0^4,9>tetradec-1(2)-en-3-one
  参考文献：
  名称：

  180.熔融碳环。第十六部分。过氢菲的立体异构：初步研究

  摘要：

  DOI：

  10.1039/jr9390000842

文献信息

• Synthetic route to tricyclic carbon compounds by Friedel–crafts acylation
  作者：Arlette Tubul、Maurice Santelli

  DOI：10.1039/c39880000191

  日期：——

  Acylation of cyclohexene by cyclohexenyl- or cyclopentenyl-acetyl chloride gave des-A-11-oxo or des-D-7-oxo steroids.

  通过环己烯基-或环戊烯基-乙酰氯酰化环己烯，得到des- A -11-氧代或des-D-7-氧代甾族化合物。
• Hydrophenanthrenes and Related Ring Systems from Dieneynes¹
  作者：P. S. Pinkney、G. A. Nesty、R. H. Wiley、C. S. Marvel

  DOI：10.1021/ja01297a038

  日期：1936.6
• Formation of 2-cyclohexenones by friedel-crafts acylation of alkenes with β,γ-ethylenic acyl halides
  作者：Robert Faure、Agnès Pommier、Jean-Marc Pons、Michel Rajzmann、Maurice Santelli

  DOI：10.1016/s0040-4020(01)86590-x

  日期：1992.9

  Friedel-Crafts acylation of alkenes with beta,gamma-alkenoyl halides leads to conjugated Al-trienolates able to cyclize into Al-enolates of 2-cyclohexenones through an allowed thermal disrotatory electrocyclization mechanism. Discussion of the product structure is based on two-dimensional NMR experiments (400 MHz) and molecular mechanics studies (GENMOL and MM2).
• 307. Experiments on the synthesis of substances related to the sterols. Part II. A new general method for the synthesis of substituted cyclohexenones
  作者：William Sage Rapson、Robert Robinson

  DOI：10.1039/jr9350001285

  日期：——
• TUBUL, ARLETTE;SANTELLI, MAURICE, J. CHEM. SOC. CHEM. COMMUN.,(1988) N 3, 191-192
  作者：TUBUL, ARLETTE、SANTELLI, MAURICE

  DOI：——

  日期：——