4,6-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene-1,3-dialdehyde | 1250403-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4,6-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene-1,3-dialdehyde
• 英文别名: 4,6-Bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]benzene-1,3-dicarbaldehyde；4,6-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]benzene-1,3-dicarbaldehyde
• CAS: 1250403-71-4
• 化学式: C₂₂H₃₄O₁₀
• 分子量: 458.506
• InChiKey: JMVZRVHCUJADMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  32
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  4,6-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene-1,3-dialdehyde 、 4,6-Bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]benzene-1,3-dicarbohydrazide 以 氯仿 、 二甲基亚砜 为溶剂， 反应 12.0h， 以95%的产率得到
  参考文献：
  名称：

  Hydrogen-bonded benzylidenebenzohydrazide macrocycles and oligomers: testing the robust capacity of an amide chain in promoting the formation of vesicles

  摘要：

  This Letter describes 2-(2-(dioctylamino)-2-oxoethyl-amino)-2-oxoethoxyl (DPAOE)-tuned self-assembly of vesicles from rigid macrocycles and foldamer-like oligomers. The molecules are prepared through the formation of reversible hydrazone bonds from aldehyde and benzo-hydrazide precursors, which are further facilitated by intramolecular N center dot center dot center dot H-O hydrogen bonding. SEM. AFM, and fluorescent encapsulation studies reveal that the molecules all self-assemble into vesicular structures in methanol, while similar molecules bearing the triethylene glycol or n-decyl chains do not. The results illustrate that DOAOE is robust in promoting the formation of vesicles for aromatic Systems in polar solvents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.076
• 作为产物：
  描述：

  4,6-二羟基苯-1,3-二甲醛 、 对甲苯磺酸三缩乙二醇单甲醚酯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 以85%的产率得到4,6-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene-1,3-dialdehyde
  参考文献：
  名称：

  Hydrogen-bonded benzylidenebenzohydrazide macrocycles and oligomers: testing the robust capacity of an amide chain in promoting the formation of vesicles

  摘要：

  This Letter describes 2-(2-(dioctylamino)-2-oxoethyl-amino)-2-oxoethoxyl (DPAOE)-tuned self-assembly of vesicles from rigid macrocycles and foldamer-like oligomers. The molecules are prepared through the formation of reversible hydrazone bonds from aldehyde and benzo-hydrazide precursors, which are further facilitated by intramolecular N center dot center dot center dot H-O hydrogen bonding. SEM. AFM, and fluorescent encapsulation studies reveal that the molecules all self-assemble into vesicular structures in methanol, while similar molecules bearing the triethylene glycol or n-decyl chains do not. The results illustrate that DOAOE is robust in promoting the formation of vesicles for aromatic Systems in polar solvents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.076

文献信息

• 一种六元亚胺环化合物及一锅法合成六元亚胺环化合物的方法
  申请人：首都医科大学

  公开号：CN108218803A

  公开（公告）日：2018-06-29

  本发明属于化学合成领域，具体涉及一种六元亚胺环化合物及一锅法合成六元亚胺环化合物的方法。本发明是以间苯二甲醛衍生物和间苯二胺衍生物为原料，经过硼氢化钠还原，一锅法合成六元亚胺环衍生物。本发明的合成方法的优点：a)反应条件温和，可操作性强；b)反应条件可控、选择性的合成带有不同取代基的六元亚胺环，其中间孔径可控；c)可适用于工业生产；d)应用广泛，适合不同类型的六元亚胺环化合物的合成，具有较大的实施价值和效益，其在放射性药物化学多功能螯合剂、离子识别、离子通道、材料和医药等领域具有潜在的应用价值。
• One-Pot formation of novel [3+3] NH-CH2 bridged cyclophanes
  作者：Yong Huang、Yajing Liu、Song Liu、Renbo Wu、Zehui Wu

  DOI：10.1016/j.tetlet.2018.04.005

  日期：2018.5

  The new [3+3] NH-CH2 bridged cyclophanes bearing different functional groups and different cavity sizes were prepared in one pot by treating diamine derivatives with dialdehyde derivatives. Factors important for efficiently form-ing these macrocycles include reaction concentration (10 or 100 mmol), temperature (room temperature or 40–50 °C) and solvent (CHCl3). Preliminary fluorescence spectrometer

  通过用二醛衍生物处理二胺衍生物，在一个罐中制备了具有不同官能团和不同空腔尺寸的新的[3 + 3] NH-CH 2桥接的环烷。有效形成这些大环化合物的重要因素包括反应浓度（10或100 mmol），温度（室温或40–50°C）和溶剂（CHCl 3）。初步的荧光光谱仪和HRMS-ESI研究表明，带有3个羟基（3c）的新型[3 + 3] NH-CH 2桥联环烷的内腔是用于肉眼检测PBS缓冲液中Ag +的新型高选择性探针。
• Hydrogen-bonded benzylidenebenzohydrazide macrocycles and oligomers: testing the robust capacity of an amide chain in promoting the formation of vesicles
  作者：Ben-Ye Lu、Guang-Jun Sun、Jian-Bin Lin、Xi-Kui Jiang、Xin Zhao、Zhan-Ting Li

  DOI：10.1016/j.tetlet.2010.05.076

  日期：2010.7

  This Letter describes 2-(2-(dioctylamino)-2-oxoethyl-amino)-2-oxoethoxyl (DPAOE)-tuned self-assembly of vesicles from rigid macrocycles and foldamer-like oligomers. The molecules are prepared through the formation of reversible hydrazone bonds from aldehyde and benzo-hydrazide precursors, which are further facilitated by intramolecular N center dot center dot center dot H-O hydrogen bonding. SEM. AFM, and fluorescent encapsulation studies reveal that the molecules all self-assemble into vesicular structures in methanol, while similar molecules bearing the triethylene glycol or n-decyl chains do not. The results illustrate that DOAOE is robust in promoting the formation of vesicles for aromatic Systems in polar solvents. (C) 2010 Elsevier Ltd. All rights reserved.