2-(4-(benzyloxy)phenyl)-1H-indole | 58995-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(4-(benzyloxy)phenyl)-1H-indole
• 英文别名: 2-(4'-Benzyloxy-phenyl)-indole；2-(4-phenylmethoxyphenyl)-1H-indole
• CAS: 58995-82-7
• 化学式: C₂₁H₁₇NO
• 分子量: 299.372
• InChiKey: DBQZROFCPLKUTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  25
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-(benzyloxy)phenyl)-1H-indole 在 氨 、 sodium amide 作用下， 生成 2-(4'-(benzyloxy)phenyl)-N-methylindole
  参考文献：
  名称：

  Ames et al., Journal of the Chemical Society, 1959, p. 3388,3396

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(1-(2-phenylhydrazono)ethyl)phenol 在 乙醇 、 sodium ethanolate 、 zinc(II) chloride 作用下， 生成 2-(4-(benzyloxy)phenyl)-1H-indole
  参考文献：
  名称：

  Ames et al., Journal of the Chemical Society, 1959, p. 3388,3396

  摘要：

  DOI：

文献信息

• 2-Phenyl-indole derivatives and process for preparing the same
  申请人：Labaz

  公开号：US04057530A1

  公开（公告）日：1977-11-08

  New stabilizers of polymers and co-polymers of vinyl chloride, the said stabilizers being 2-phenyl-indole derivatives corresponding to the formula: ##STR1## wherein R represents a phenyl radical, an amino group, optionally substituted by an acetyl or benzoyl radical, a mercapto group, optionally substituted by a branched-or straight-chain alkyl group containing from 1 to 12 carbon atoms or by a cyclohexyl radical, a carboxyl radical, a radical represented by the formula: R.sub.1 O-- wherein R.sub.1 represents a hydrogen atom, an isopropyl, carboxymethyl, carbethoxymethyl, carbethoxyisopropyl, acetyl, docosanoyl, benzoyl, benzyl, or allyl radical or a branched-or straight-chain alkyl radical containing from 6 to 12 carbon atoms.

  新型稳定剂用于聚合物和氯乙烯共聚物，所述稳定剂为与下式对应的2-苯基吲哚衍生物：##STR1## 其中R代表苯基基团，氨基团，可选地由乙酰基或苯甲酰基取代，巯基，可选地由含有1至12个碳原子的支链或直链烷基基团或环己基基团取代，羧基基团，由下式表示的基团：R.sub.1 O--其中R.sub.1代表氢原子，异丙基，羧甲基，羧乙氧甲基，羧乙氧异丙基，乙酰基，二十二烷酰基，苯甲酰基，苄基或烯丙基基团或含有6至12个碳原子的支链或直链烷基基团。
• [EN] USE OF INDOLE, 6- AND 7-AZAINDOLE DERIVATIVES AS INHIBITORS OF FERROPTOSIS REGULATED CELL DEATH<br/>[FR] UTILISATION D'INDOLE, DE DÉRIVÉS DE 6-ET 7-AZAINDOLE COMME INHIBITEURS DE LA MORT CELLULAIRE RÉGULÉE PAR LA FERROPTOSE
  申请人：SEABELIFE

  公开号：WO2022157392A1

  公开（公告）日：2022-07-28

  The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.

  本发明涉及以下一般式（I）的化合物或其药学上可接受的盐和/或溶剂，用作抑制铁死亡的药物。
• Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives – An extended structure–activity relationship study
  作者：Siavosh Mahboobi、Emerich Eichhorn、Matthias Winkler、Andreas Sellmer、Ute Möllmann

  DOI：10.1016/j.ejmech.2007.05.009

  日期：2008.3

  Compounds containing 3-bromo-2,5-dihydro-1H-2,5-pyrroledione and indole substructures were found to have antibacterial activity against resistant strains of Staphylococcus aureus and some other Gram positive bacteria. The investigated compounds exhibit minimal inhibition concentrations (MICs) lower than those of common antibiotics like vancomycin or ciprofloxacin. Activity against multiresistant strains suggests a mechanism of action different from common antibiotics. This might be important in circumventing existing resistance mechanisms. Here we report about the antibacterial activity in an extended structure-activity relationship study. (c) 2007 Elsevier Masson SAS. All rights reserved.
• INION H.; VOGELAEV DE H.; DESCAMPS M.; BAUTHIER J.; COLOT M.; RICHARD J.;+, EUR. J. MED. CHEM., 1977, 12, NO 5, 483-487
  作者：INION H.、 VOGELAEV DE H.、 DESCAMPS M.、 BAUTHIER J.、 COLOT M.、 RICHARD J.、+

  DOI：——

  日期：——
• ANTITHROMBOTIC AGENTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1011666A1

  公开（公告）日：2000-06-28