5-Hydroxy-7-methoxy-2-(4-methylphenyl)-2,3-dihydrochromen-4-one | 1042741-40-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5-Hydroxy-7-methoxy-2-(4-methylphenyl)-2,3-dihydrochromen-4-one
• 英文别名: 5-hydroxy-7-methoxy-2-(4-methylphenyl)-2,3-dihydrochromen-4-one
• CAS: 1042741-40-1
• 化学式: C₁₇H₁₆O₄
• 分子量: 284.312
• InChiKey: HGQLSXXBJHHWAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 以63%的产率得到5-Hydroxy-7-methoxy-2-(4-methylphenyl)-2,3-dihydrochromen-4-one
  参考文献：
  名称：

  Efficient One‐Pot Synthesis of Hydroxyflavanones by Cyclization andO‐Demethylation of Methoxychalcones

  摘要：

  An efficient one-pot method for the synthesis of hydroxyflavanones is described. Methoxychalcones are treated with 36% HBr to afford cyclization and regioselective O-demethylation products (2a-i) while cyclization and complete O-demethylation products (3a-e) are obtained in the presence of 45% HI.

  DOI：

  10.1080/00397910801991465

文献信息

• Efficient One‐Pot Synthesis of Hydroxyflavanones by Cyclization and<i>O</i>‐Demethylation of Methoxychalcones
  作者：Tao Liu、Huazhou Ying、Guan Lin、Yongzhou Hu

  DOI：10.1080/00397910801991465

  日期：2008.5

  An efficient one-pot method for the synthesis of hydroxyflavanones is described. Methoxychalcones are treated with 36% HBr to afford cyclization and regioselective O-demethylation products (2a-i) while cyclization and complete O-demethylation products (3a-e) are obtained in the presence of 45% HI.