(2-methylpyridin-4-yl)(phenyl)methanone | 59576-25-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-methylpyridin-4-yl)(phenyl)methanone
• 英文别名: (2-methylpyridin-4-yl)-phenylmethanone
• CAS: 59576-25-9
• 化学式: C₁₃H₁₁NO
• 分子量: 197.236
• InChiKey: XTMVNVYVPNLZIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-溴-2-甲基吡啶 在 copper(l) iodide 、 lithium chloride 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 26.0h， 生成 (2-methylpyridin-4-yl)(phenyl)methanone
  参考文献：
  名称：

  Preparation 2-Substituted-4-pyridylzinc Bromides via Direct Insertion of Active Zinc and Their Coupling Reactions

  摘要：

  DOI：

  10.5012/bkcs.2013.34.5.1575

文献信息

• Merging Photoredox and Nickel Catalysis: The Direct Synthesis of Ketones by the Decarboxylative Arylation of α-Oxo Acids
  作者：Lingling Chu、Jeffrey M. Lipshultz、David W. C. MacMillan

  DOI：10.1002/anie.201501908

  日期：2015.6.26

  The direct decarboxylative arylation of α‐oxo acids has been achieved by synergistic visible‐light‐mediated photoredox and nickel catalysis. This method offers rapid entry to aryl and alkyl ketone architectures from simple α‐oxo acid precursors via an acyl radical intermediate. Significant substrate scope is observed with respect to both the oxo acid and arene coupling partners. This mild decarboxylative

  通过协同的可见光介导的光氧化还原和镍催化，已经实现了α-氧代酸的直接脱羧芳基化。该方法可通过简单的α-氧代酸前体通过酰基自由基中间体快速进入芳基和烷基酮体系。就含氧酸和芳烃偶联伙伴而言，观察到显着的底物范围。如非诺贝特的快速合成所证明的，这种温和的脱羧芳基化作用还可用于有效地获得药物。
• METAL COMPLEX DYE, PHOTOELECTRIC CONVERSION ELEMENT, DYE-SENSITIZED SOLAR CELL, DYE SOLUTION, AND COMPOUND
  申请人：Fujifilm Corporation

  公开号：EP2793311A1

  公开（公告）日：2014-10-22

  A photoelectric conversion element, having: an electrically-conductive support; a photoconductor layer having a layer of semiconductor fine-particles that have adsorbed a dye; a charge transfer layer containing an electrolyte; and a counter electrode; which are provided on one side of the electrically-conductive support in this order, wherein the dye has at least one terdentate ligand having at least one acidic group; at least one ligand coordinating to a metal atom M has an sp2 carbon atom; a cyclic group binds to the sp2 carbon atom; in a circle position connecting through a carbon atom(s) from an atom of the cyclic group directly binding to the sp2 carbon atom, a substituent R is substituted at an atom of an α-position or β-position to the atom of the cyclic group directly binding to the sp2 carbon atom, with the substituent R being selected from a linear or branched alkyl group, a cycloalkyl group, an alkoxy group, a cycloalkoxy group, an aryloxy group, an alkylthio group, a cycloalkylthio group, an arylthio group, an amino group, an alkylamino group, a cycloalkylamino group, an arylamino group, a heterocyclic amino group, a silyl group, or a silyloxy group; and when the atom of the α-position or β-position to which the substituent R binds is defined as G1 and an atom of the substituent R which directly binds to the atom G1 is defined as G2, an angle θ (∠MG1G2) formed by the metal atom M, the atom G1 and the atom G2, which is centered on the atom G1, is 150° or less, a dye-sensitized solar cell, a metal complex dye, a dye solution containing the dye and a compound useful as a ligand of the dye.

  一种光电转换元件，具有 导电支架 光电导体层，该层具有一层吸附了染料的半导体微粒； 含有电解质的电荷转移层；以及 一个对电极； 它们依次设置在导电支架的一侧、 其中，染料具有至少一个三齿配体，该配体具有至少一个酸性基团；至少一个配体与具有 sp2 碳原子的金属原子 M 配位；一个环状基团与 sp2 碳原子结合；在通过碳原子与直接结合到 sp2 碳原子的环状基团的原子相连的圆周位置上，在与直接结合到 sp2 碳原子的环状基团的原子处于 α 位或 β 位的原子上取代取代基 R，取代基 R 选自直链或支链烷基、环烷基、烷氧基、环烷氧基、芳氧基、烷硫基、环烷硫基、芳硫基、氨基、烷基氨基、环烷基氨基、芳基氨基、杂环氨基、硅烷基或硅烷氧基；当取代基 R 与之结合的 α 位或 β 位原子被定义为 G1，而取代基 R 直接与原子 G1 结合的原子被定义为 G2 时，金属原子 M 与原子 G1 形成的角度θ (∠MG1G2)、以原子 G1 为中心，由金属原子 M、原子 G1 和原子 G2 形成的角度θ (∠MG1G2)为 150°或更小。
• PHOTOELECTRIC CONVERSION ELEMENT AND DYE-SENSITIZED SOLAR CELL
  申请人：FUJI-FILM Corporation

  公开号：EP2903077A1

  公开（公告）日：2015-08-05

  A photoelectric conversion element includes a conductive substrate, a photosensitive layer containing an electrolyte, a charge transfer layer containing an electrolyte, and a counter electrode, in which the photosensitive layer contains semiconductor particles loaded with a metal complex dye represented by the following Formula (1). A dye-sensitized solar cell uses the photoelectric conversion element.         M(LD)(LA)(X)m·CI     Formula (1) In the formula (1), M represents a divalent or trivalent metal ion; LD represents a bidentate or tridentate ligand having an aryl group or an heterocyclic group; and the ligand has 1 to 3 atoms that are coordinated with M by becoming an anion. LA represents a tridentate ligand represented by a specific formula; X represents a monodentate ligand; CI represents a counter ion necessary for neutralizing a charge; and m represents 0 or 1.

  一种光电转换元件包括导电基板、含有电解质的光敏层、含有电解质的电荷转移层和对电极，其中光敏层含有装有下式（1）表示的金属络合染料的半导体颗粒。染料敏化太阳能电池使用光电转换元件。 M(LD)(LA)(X)m-CI 公式 (1) 式（1）中，M 代表二价或三价金属离子；LD 代表具有芳基或杂环基的双叉或三叉配体；配体具有 1 至 3 个原子，通过成为阴离子与 M 配位。LA 代表由特定式子表示的三叉配体；X 代表单齿配体；CI 代表中和电荷所需的反离子；m 代表 0 或 1。
• Decarboxylative cross-coupling and applications thereof
  申请人：THE TRUSTEES OF PRINCETON UNIVERSITY

  公开号：US10538509B2

  公开（公告）日：2020-01-21

  Methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. A method described herein, in some embodiments, comprises providing a reaction mixture including a photoredox catalyst, a transition metal catalyst, a coupling partner and a substrate having a carboxyl group. The reaction mixture is irradiated with a radiation source resulting in cross-coupling of the substrate and coupling partner via a mechanism including decarboxylation, wherein the coupling partner is selected from the group consisting of a substituted aromatic compound and a substituted aliphatic compound.

  本文所述的方法可通过使用光氧化还原和过渡金属催化剂进行脱羧交叉偶联来生产多种分子物质。在某些实施方案中，本文所述的方法包括提供一种反应混合物，其中包括一种光氧化催化剂、一种过渡金属催化剂、一种偶联剂和一种具有羧基的基质。用辐射源照射反应混合物，通过包括脱羧在内的机理使基质和偶联剂发生交叉偶联，其中偶联剂选自由取代的芳香族化合物和取代的脂肪族化合物组成的组。
• Yamamoto, Yutaka; Yanagi, Akihiko, Heterocycles, 1982, vol. 19, # 1, p. 41 - 44
  作者：Yamamoto, Yutaka、Yanagi, Akihiko

  DOI：——

  日期：——