2-甲基-5-乙氧基嘧啶 | 35231-57-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-甲基-5-乙氧基嘧啶
• 中文别名: 5-乙氧基-2-甲基嘧啶
• 英文名称: 5-ethoxy-2-methyl-pyrimidine
• 英文别名: 5-Ethoxy-2-methylpyrimidine
• CAS: 35231-57-3
• 化学式: C₇H₁₀N₂O
• 分子量: 138.169
• InChiKey: VSERGMRZNGXZRK-UHFFFAOYSA-N

物化性质

• 沸点：
  200.1±13.0 °C(Predicted)
• 密度：
  1.041±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• TRICYCLIC GYRASE INHIBITORS
  申请人：Bensen Daniel

  公开号：US20120238751A1

  公开（公告）日：2012-09-20

  Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

  本文披露了具有式I结构的化合物，以及作为抗菌有效的三环酶抑制剂的药用盐、酯和前药，相关的药物组合物、用途和制备该化合物的方法也在考虑之中。
• CONDENSED CYCLIC COMPOUND HAVING DOPAMINE D3 RECEPTOR ANTAGONISM
  申请人：Shionogi & Co., Ltd

  公开号：EP3744721A1

  公开（公告）日：2020-12-02

  Novel compounds having a D3 receptor antagonistic effect are provided. The compound represented by Formula (IA)': wherein A is S or O; R1a is substituted or unsubstituted alkyloxy or the like, R2a to R2d are each independently hydrogen atoms or the like, ring B is a 4- to 8-membered non-aromatic carbocycle or the like, R3 is each independently halogen or the like, r is an integer of 0 to 4, R4 is substituted or unsubstituted aromatic heterocyclyl or the like, or a pharmaceutically acceptable salt thereof.

  提供了具有 D3 受体拮抗作用的新型化合物。 由式（IA）'代表的化合物： 其中 A 是 S 或 O；R1a 是取代或未取代的烷氧基或类似物；R2a 至 R2d 各自独立地是氢原子或类似物；环 B 是 4 至 8 元非芳族碳环或类似物；R3 各自独立地是卤素或类似物；r 是 0 至 4 的整数；R4 是取代或未取代的芳族杂环或类似物、 或其药学上可接受的盐。
• Tricyclic Gyrase inhibitors
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US10865216B2

  公开（公告）日：2020-12-15

  Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

  本文公开了具有式 I 结构的化合物及其药学上适用的盐、酯和原药，它们可作为抗菌有效的三环回旋酶抑制剂。此外，本文还公开了三环回旋酶抑制剂化合物的种类。 还考虑了相关的药物组合物、用途和化合物的制造方法。
• Malononitrile Compounds for Controlling Animal Pests
  申请人：BASF SE

  公开号：US20160066573A1

  公开（公告）日：2016-03-10

  The invention relates to the use of a compound of formula (I) or a salt thereof for combating animal pests, where the symbols and indices are defined in the specification.
• CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 RECEPTOR ANTAGONISTIC EFFECT
  申请人：Shionogi & Co., Ltd.

  公开号：US20210040117A1

  公开（公告）日：2021-02-11

  Novel compounds having a D3 receptor antagonistic effect are provided. The compound represented by Formula (IA)′: wherein A is S or O; R 1a is substituted or unsubstituted alkyloxy or the like, R 2a to R 2d are each independently hydrogen atoms or the like, ring B is a 4- to 8-membered non-aromatic carbocycle or the like, R 3 is each independently halogen or the like, r is an integer of 0 to 4, R 4 is substituted or unsubstituted aromatic heterocyclyl or the like, or a pharmaceutically acceptable salt thereof.