1-Methyl-2-(1-hydroxy-aethyl)-cyclopropan | 19293-90-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Methyl-2-(1-hydroxy-aethyl)-cyclopropan
• 英文别名: 1-<2-Methyl-cyclopropyl>-ethanol-(1)；1-Methyl-2-(1-hydroxyethyl)-cyclopropan；1-(2-methyl-cyclopropyl)-ethanol；1-(2-Methylcyclopropyl)ethanol
• CAS: 19293-90-4
• 化学式: C₆H₁₂O
• 分子量: 100.161
• InChiKey: WLNGEWJRGOHNAA-UHFFFAOYSA-N

物化性质

• 沸点：
  131-135 °C
• 密度：
  0.941±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Methyl-2-(1-hydroxy-aethyl)-cyclopropan 在 氢溴酸 作用下， 生成 5-溴-1-己烯
  参考文献：
  名称：

  Julia,M. et al., Bulletin de la Societe Chimique de France, 1960, p. 1735 - 1739

  摘要：

  DOI：
• 作为产物：
  描述：

  5-acetoxy-4-methyl-pentan-2-one 在 盐酸 、 sodium hydroxide 、 钾硼氢 作用下， 以 甲醇 、 水 为溶剂， 生成 1-Methyl-2-(1-hydroxy-aethyl)-cyclopropan
  参考文献：
  名称：

  Julia,M. et al., Bulletin de la Societe Chimique de France, 1960, p. 1735 - 1739

  摘要：

  DOI：

文献信息

• OXAZOLIDINONES AS MODULATORS OF MGLUR5
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160237072A1

  公开（公告）日：2016-08-18

  The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be useful for the treatment of various disorders of the central nervous system.

  该披露通常涉及I式化合物及其盐，以及使用这些化合物的组合物和方法。这些化合物是mGluR5受体的配体，激动剂和部分激动剂，并且可能对治疗中枢神经系统的各种疾病有用。
• CARBOSTYRIL DERIVATIVES
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0450066A1

  公开（公告）日：1991-10-09

  This invention relates to carbostyril derivatives represented by general formula (1), a process for their preparation, and an agent for inhibiting agglutination of platelets containing them as an active ingredient, wherein A represents a lower alkylene group, R1 represents a substituted or unsubstituted cycloalkyl-lower alkyl group, a cycloalkyl group, a tetrahydropyranyl* lower alkyl group, a lower alkylenedioxy-substituted lower alkyl group, a substituted phenyl-lower alkyl group or a lower alkyl-substituted piperidinyl-lower alkyl group, R2 represents a substituted or unsubstituted 5- or 6-membered, saturated or unsaturated heterocyclic-lower alkyl group, a tetrahydropyranylthio-lower alkyl group, a pyridylthio-lower alkyl group, a lower alkylene-dioxy-substituted lower alkyl group or a substituted or unsubstituted lower alkyl group, and the carbon-to-carbon bond between the 3- position and the 4-position of the carbostyril skeleton represents either a single or a double bond.

  本发明涉及通式(1)代表的碳化二氢吡啶衍生物、其制备工艺以及含有其作为活性成分的抑制血小板凝集的制剂，其中A代表低级亚烷基，R1代表取代或未取代的环烷基-低级烷基、环烷基、四氢吡喃基*低级烷基、低级亚烷基-二氧基取代的低级烷基、取代的苯基-低级烷基或低级烷基-取代的哌啶基-低级烷基、R2 代表取代或未取代的 5 或 6 元、饱和或不饱和杂环低级烷基、四氢吡喃硫基低级烷基、吡啶硫基低级烷基、亚烷基二氧基取代的低级烷基或取代或未取代的低级烷基，碳四吡啶骨架的 3 位和 4 位之间的碳-碳键代表单键或双键。
• Derivatives of beta-aminopropionic acid with a fungicidal activity
  申请人：ISAGRO RICERCA S.r.l.

  公开号：EP0718280A2

  公开（公告）日：1996-06-26

  Compounds based on derivatives of β-aminopropionic acid having the general formula (I): The compounds having general formula (I) have a high antifungal activity.

  基于通式(I)的β-氨基丙酸衍生物的化合物： 通式（I）的化合物具有很高的抗真菌活性。
• Use of Beta-aminopropionic acid derivatives as fungicides
  申请人：ISAGRO RICERCA S.r.l.

  公开号：EP0843967A1

  公开（公告）日：1998-05-27

  The present application relates to the use of compounds of formula (IX): wherein R1, R2, R3, Rc Ar and Q have the meanings given in the description, as fungicides.

  本申请涉及式 (IX) 化合物作为杀菌剂的用途： 其中 R1、R2、R3、Rc Ar 和 Q 具有说明中给出的含义。
• Method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step
  申请人：Marliere, Philippe

  公开号：EP2336341A1

  公开（公告）日：2011-06-22

  Described is a method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step. The conversion preferably makes use of an unsaturated fatty acid hydratase, in particular of an oleate hydratase (EC 4.2.1.53). Moreover, the present invention describes a recombinant organism which produces an alcohol and which expresses a hydratase enzyme which is capable of catalyzing the conversion of said alcohol into an alkene.

  所述的是一种生产烯烃的方法，包括通过酶脱水步骤转化醇的步骤。这种转化最好使用不饱和脂肪酸氢化酶，特别是油酸氢化酶（EC 4.2.1.53）。此外，本发明还描述了一种重组生物体，该生物体能产生一种醇，并能表达一种水解酶，该酶能催化所述醇向烯烃的转化。