2-甲基庚烷-2,3-二醇 | 1068-81-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-甲基庚烷-2,3-二醇
• 英文名称: 2-methylheptane-2,3-diol
• 英文别名: 2-Methylheptandiol-2.3
• CAS: 1068-81-1
• 化学式: C₈H₁₈O₂
• 分子量: 146.23
• InChiKey: GPAKPLDUZKETOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-甲基庚烷-2,3-二醇 在 吡啶 、 锌 作用下， 生成 2-甲基-2-庚烯
  参考文献：
  名称：

  Heterogeneous reactions with zinc. II. General synthesis of ketones from 1,2-trisubstituted glycol monoesters and the mechanism of the serini reaction

  摘要：

  DOI：

  10.1021/jo00828a025
• 作为产物：
  描述：

  2-甲基-2-庚烯 在 四氧化锇 作用下， 生成 2-甲基庚烷-2,3-二醇
  参考文献：
  名称：

  Rh-Catalyzed Enantioselective Diboration of Simple Alkenes:  Reaction Development and Substrate Scope

  摘要：

  The rhodium-catalyzed reaction between bis(catecholato)diboron and simple alkenes results in the syn addition of the diboron across the alkene. The resulting 1,2-bis(boronate) is subsequently oxidized to provide the 1,2-diol. In the presence of enantiomerically enriched Quinap ligand, high enantioselection in the diboration can be achieved. The reaction is highly selective for trans- and trisubstituted alkenes and can be selective for some monosubstituted alkenes as well. The development of this reaction is described as is the substrate scope and experiments that are informative about the reaction mechanism and competing pathways.

  DOI：

  10.1021/jo051651m

文献信息

• Olefin-Dependent Discrimination between Two Nonheme HOFe^VO Tautomeric Species in Catalytic H₂O₂Epoxidations
  作者：Anna Company、Yan Feng、Mireia Güell、Xavi Ribas、Josep M. Luis、Lawrence Que、Miquel Costas

  DOI：10.1002/chem.200802597

  日期：2009.3.23

  water incorporation into products (up to 75 %) is observed in epoxidation reactions with H2O2 by a bioinspired nonheme iron catalyst. A surprising substrate‐dependent incorporation of water is observed, and is proposed to arise from fast equilibrium between two high‐valent HOFeVO isomeric species exhibiting different reactivity.

  湿式加氧酶模型：在通过生物启发的非血红素铁催化剂与H 2 O 2进行的环氧化反应中，观察到前所未有的高水平的水混入产品（高达75％）。水的令人惊讶的衬底依赖性掺入观察到的，并提出了两个高价HO之间从快速平衡出现铁V表现出不同的反应性O异构体物种。
• Mo–Catalyzed One‐Pot Synthesis of <i>N</i> ‐Polyheterocycles from Nitroarenes and Glycols with Recycling of the Waste Reduction Byproduct. Substituent‐Tuned Photophysical Properties
  作者：Raquel Hernández‐Ruiz、Rubén Rubio‐Presa、Samuel Suárez‐Pantiga、María R. Pedrosa、Manuel A. Fernández‐Rodríguez、M. José Tapia、Roberto Sanz

  DOI：10.1002/chem.202102000

  日期：2021.9.24

  reduction–imine formation–intramolecular cyclization–oxidation for the general synthesis of a wide variety of biologically relevant N-polyheterocycles, such as quinoxaline- and quinoline-fused derivatives, and phenanthridines, is reported. A simple, easily available, and environmentally friendly dioxomolybdenum(VI) complex has proven to be a highly efficient and versatile catalyst for transforming a

  据报道，催化多米诺还原-亚胺形成-分子内环化-氧化用于一般合成各种生物学相关的N-多杂环，例如喹喔啉和喹啉稠合衍生物以及菲啶。一种简单、易得且环保的二氧代钼(VI)络合物已被证明是一种高效且多功能的催化剂，可用于转化涉及多种氧化还原过程的各种起始硝基芳烃。这不仅是一种可持续、步骤经济且耐空气和耐湿的方法，而且值得强调的是，序列第一步中产生的废物副产物被回收并合并到最终的目标分子中，从而改善了整体合成效率。此外，选定的吲哚喹喔啉在环己烷和甲苯中进行了光物理表征，烷基衍生物的荧光量子产率高于 0.7。
• Methyltrioxorhenium supported on silica tethered with polyethers as catalyst for the epoxidation of alkenes with hydrogen peroxide
  作者：Ronny Neumann、Tie-Jun Wang

  DOI：10.1039/a704496h

  日期：——

  Methyltrioxorhenium has been supported on silica functionalized with polyether tethers; in the absence of an organic solvent, this catalytic assembly catalysed the epoxidation of alkenes with 30% aqueous H2O2 in high selectivity compared to the ring opening products observed in homogeneous media.

  甲基三氧化铼已被支持在用聚醚链修饰的二氧化硅上；在没有有机溶剂的情况下，该催化装置以高选择性催化了烯烃与30%水合过氧化氢的环氧化反应，相比于在均相介质中观察到的开环产物。
• [EN] CATALYZED ENANTIOSELECTIVE TRANSFORMATION OF ALKENES<br/>[FR] TRANSFORMATION ENANTIO-SELECTIVE CATALYSEE D'ALCENES
  申请人：UNIV NORTH CAROLINA

  公开号：WO2005012209A3

  公开（公告）日：2005-08-11
• Osmium on Chelate Resin: Nonvolatile Catalyst for the Synthesis of Diols from Alkenes
  作者：Yasunari Monguchi、Hironao Sajiki、Fumika Wakayama、Hitoshi Takada、Yoshinari Sawama

  DOI：10.1055/s-0034-1379990

  日期：——